2024
Leukocytospermia does not negatively impact outcomes in in vitro fertilization cycles with intracytoplasmic sperm injection and preimplantation genetic testing for aneuploidy: findings from 5435 cycles
Gill P, Puchalt N, Molinaro T, Werner M, Seli E, Hotaling J, Cheng P. Leukocytospermia does not negatively impact outcomes in in vitro fertilization cycles with intracytoplasmic sperm injection and preimplantation genetic testing for aneuploidy: findings from 5435 cycles. Journal Of Assisted Reproduction And Genetics 2024, 41: 1213-1219. PMID: 38642270, PMCID: PMC11143111, DOI: 10.1007/s10815-024-03085-x.Peer-Reviewed Original ResearchConceptsLive birth rateIntracytoplasmic sperm injectionClinical pregnancy rateSustained implantation ratesIn vitro fertilizationIn vitro fertilization cyclesPreimplantation genetic testingBlastulation ratePGT-AAneuploidy rateEmbryological outcomesSperm injectionGenetic testingEuploid embryo transferPrevalence of leukocytospermiaRetrospective cohort studyMale partner ageImplantation rateBaseline characteristicsEmbryo transferLeukocytospermiaFertilization cyclesCohort studyPregnancy ratePrimary outcomeDoes recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123 987 patients
Gill P, Ata B, Arnanz A, Cimadomo D, Vaiarelli A, Fatemi H, Ubaldi F, Garcia-Velasco J, Seli E. Does recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123 987 patients. Human Reproduction 2024, 39: 974-980. PMID: 38452358, DOI: 10.1093/humrep/deae040.Peer-Reviewed Original ResearchEuploid blastocyst transferLive birth rateCumulative live birth rateBlastocyst transferEmbryo transferEuploid blastocystsImplant failureBirth ratePreimplantation genetic testing cyclesMulti-center retrospective studyDay of embryo transferCongenital uterine anomaliesEuploid embryo transferComprehensive chromosome screeningEndometrial preparation protocolsNon-obstructive azoospermiaModified natural cyclePositive pregnancy testOvarian stimulation protocolsRecurrent implantation failureParental karyotype abnormalitiesChromosome copy numberEuploid transfersTrophectoderm biopsyUterine anomalies
2022
The chances of obtaining a euploid embryo and subsequent live birth remain consistent with national age-based rates after an in vitro fertilization cycle that produced only aneuploid embryos
Herlihy NS, Klimczak AM, Cheung JKW, Seli E, Scott RT. The chances of obtaining a euploid embryo and subsequent live birth remain consistent with national age-based rates after an in vitro fertilization cycle that produced only aneuploid embryos. Fertility And Sterility 2022, 118: 484-491. PMID: 35691719, DOI: 10.1016/j.fertnstert.2022.05.026.Peer-Reviewed Original ResearchConceptsLive birth rateAge groupsEuploid embryosAneuploid embryosFertilization cyclesCumulative live birth rateBirth rateYoung womenAge-appropriate counselingInitial IVF cycleSecond IVF attemptRetrospective cohort studyPercentage of patientsPrognosis of patientsFirst embryo transferSubsequent live birthAge-based standardsSame age groupPreimplantation genetic testingHigher chanceAssisted Reproductive TechnologyIVF cyclesCohort studyFavorable prognosisIVF attemptsFollicular activation in women previously diagnosed with poor ovarian response: a randomized, controlled trial
Díaz-García C, Herraiz S, Pamplona L, Subirá J, Soriano MJ, Simon C, Seli E, Pellicer A. Follicular activation in women previously diagnosed with poor ovarian response: a randomized, controlled trial. Fertility And Sterility 2022, 117: 747-755. PMID: 35367015, DOI: 10.1016/j.fertnstert.2021.12.034.Peer-Reviewed Original ResearchConceptsPoor ovarian responseAntral follicle countOvarian reserve markersLive birth rateOvarian fragmentationFollicular activationFollicle countOvarian responseReserve markersHormone levelsPregnancy rateReproductive outcomesEmbryo transferTotal antral follicle countMII oocytesSerum antimüllerian hormoneAntimüllerian hormone levelsBirth rateMetaphase II oocytesEmbryology (ESHRE) criteriaHippo pathway inhibitionAntimüllerian hormoneSecondary outcomesFertilization cyclesIVF outcomes
2021
B-cell lymphoma 6 expression is not associated with live birth in a normal responder in vitro fertilization population
Klimczak AM, Herlihy NS, Scott CS, Hanson BM, Kim JG, Titus S, Seli E, Scott RT. B-cell lymphoma 6 expression is not associated with live birth in a normal responder in vitro fertilization population. Fertility And Sterility 2021, 117: 351-358. PMID: 34809978, DOI: 10.1016/j.fertnstert.2021.09.036.Peer-Reviewed Original ResearchConceptsB-cell lymphoma 6 (Bcl6) expressionLive birth groupLive birthsFertilization populationNormal respondersBirth groupProportion of patientsLive birth ratePopulation of patientsEuploid embryo transferCase-control studyEndometrial tissue samplesPreimplantation genetic testingGroup of womenIVF stimulationMean HSCOREIVF outcomesInfertility centerIVF successMAIN OUTCOMEGroup 2Group 1Embryo transferPatientsClinical decisionThe Appraisal of Body Content (ABC) trial: Increased male or female adiposity does not significantly impact in vitro fertilization laboratory or clinical outcomes
Kim J, Patounakis G, Juneau C, Morin S, Neal S, Bergh P, Seli E, Scott R. The Appraisal of Body Content (ABC) trial: Increased male or female adiposity does not significantly impact in vitro fertilization laboratory or clinical outcomes. Fertility And Sterility 2021, 116: 444-452. PMID: 33581854, DOI: 10.1016/j.fertnstert.2020.12.037.Peer-Reviewed Original ResearchConceptsBody mass indexBioelectric impedance analysisLive birth rateLow birth weightClinical outcomesMiscarriage rateBlastocyst formation rateEuploidy rateImplantation rateBirth weightLow birth weight/Low birth weight infantsNormal weight patientsBirth weight infantsProspective cohort studyImpact of obesityFertilization laboratoryBirth rateFertilization rateBF categoriesWeight patientsMaternal obesityWeight infantsCohort studyObese women
2020
Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers
Pirtea P, De Ziegler D, Tao X, Sun L, Zhan Y, Ayoubi JM, Seli E, Franasiak JM, Scott RT. Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers. Fertility And Sterility 2020, 115: 45-53. PMID: 33077239, DOI: 10.1016/j.fertnstert.2020.07.002.Peer-Reviewed Original ResearchConceptsRecurrent implantation failureEuploid single-embryo transferLive birth rateSingle embryo transferImplantation rateImplantation failureEmbryo transferCumulative live birth rateSustained implantation ratesRetrospective cohort studyKaplan-Meier curvesReproductive technology centerDifference of outcomeBirth rateCumulative implantation rateLogistic regression modelsPositive heartbeatClinical pregnancyCohort studyMiscarriage rateMean ageEuploid blastocystsNormal uterusMAIN OUTCOMEGestational carrierSperm Mitochondrial DNA Copy Number Is Not a Predictor of Intracytoplasmic Sperm Injection (ICSI) Cycle Outcomes
Tiegs AW, Tao X, Landis J, Zhan Y, Franasiak JM, Seli E, Wells D, Fragouli E, Scott RT. Sperm Mitochondrial DNA Copy Number Is Not a Predictor of Intracytoplasmic Sperm Injection (ICSI) Cycle Outcomes. Reproductive Sciences 2020, 27: 1350-1356. PMID: 31994001, DOI: 10.1007/s43032-020-00163-0.Peer-Reviewed Original ResearchConceptsSperm mitochondrial DNA copy numberLive birth rateQuantitative real-time polymerase chain reactionMitochondrial DNA copy numberICSI cyclesBirth rateIntracytoplasmic sperm injection cycle outcomesBlastocyst developmentDay-3 embryo biopsyMtDNA-CNDNA copy numberBlastocyst euploidy ratesMixed-effects logistic regressionReal-time polymerase chain reactionSperm samplesEffects logistic regressionBlastocyst euploidyCohort studyPrimary outcomeSecondary outcomesInfertility centerCycle outcomeEuploidy rateMaternal ageInfertile population
2018
Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance
Morin SJ, Patounakis G, Juneau CR, Neal SA, Scott RT, Seli E. Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance. Human Reproduction 2018, 33: 1489-1498. PMID: 30010882, DOI: 10.1093/humrep/dey238.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAneuploidyBlastomeresDatabases, FactualEmbryo Culture TechniquesEmbryo TransferFemaleFertility Agents, FemaleFertilization in VitroHumansInfertility, FemaleLive BirthOvarian ReserveOvaryOvulationOvulation InductionPregnancyPregnancy RateRetrospective StudiesTreatment OutcomeConceptsPoor oocyte qualityOvarian reserveLive birth rateDiminished ovarian reserveOocyte yieldOocyte qualityBlastulation rateAMH levelsPoor respondersPoor responseFollicular depletionBirth rateEmbryo transferAneuploidy rateLower live birth ratesYoung womenSTUDY FUNDING/COMPETINGGood prognosis patientsOvarian reserve parametersOvarian reserve testingYoung poor respondersPoor ovarian responseRetrospective cohort studyLower oocyte yieldInterquartile range
2017
A universal freeze all strategy
Ata B, Seli E. A universal freeze all strategy. Current Opinion In Obstetrics & Gynecology 2017, 29: 136-145. PMID: 28333696, DOI: 10.1097/gco.0000000000000362.Peer-Reviewed Original ResearchConceptsElective frozen embryo transferFrozen embryo transferOvarian responseEmbryo transferPatient/physician preferenceReproductive technology cyclesLow ovarian responseLive birth rateMultifollicular growthHypertensive disordersOvarian stimulationPerinatal outcomesPlacenta accretaUnstimulated cyclesNew RCTsPerinatal mortalityPreclinical evidenceSerious complicationsEndometrial functionClinical evidenceRetrospective studyPhysician preferenceContradictory resultsExcessive responseAdverse effects
2012
The association between fertility clinic performance and cycle volume: implications for public reporting of provider performance data
Gong D, Seli E. The association between fertility clinic performance and cycle volume: implications for public reporting of provider performance data. Fertility And Sterility 2012, 98: 55-62.e1. PMID: 22521157, DOI: 10.1016/j.fertnstert.2012.03.036.Peer-Reviewed Original ResearchConceptsLive birth rateProvider performance dataClinic performanceSuccess rateCycle volumeReproductive technology clinicsRetrospective longitudinal analysisHealth care providersBirth ratePublic reportingART cyclesPregnancy rateART treatmentStudy populationMAIN OUTCOMECare providersStratification analysisTechnology clinicsPatient behaviorClinicDisease controlPublic quality reportingPatientsProvider performanceLongitudinal analysis