2022
The Pediatric Optic Neuritis Prospective Outcomes Study: Two-Year Results.
Pineles SL, Henderson RJ, Repka MX, Heidary G, Liu GT, Waldman AT, Borchert MS, Khanna S, Graves JS, Collinge JE, Conley JA, Davis PL, Kraker RT, Cotter SA, Holmes JM, Pediatric Eye Disease Investigator Group.. The Pediatric Optic Neuritis Prospective Outcomes Study: Two-Year Results. Ophthalmology 2022, 129: 856-864. PMID: 35364222, DOI: 10.1016/j.ophtha.2022.03.021.Peer-Reviewed Case Reports and Technical NotesVicarious trauma for surgical residents
Zolfaghari, EJ, Kuehne AK, Ramaswamy A, Tignanelli CJ, Murray A. Vicarious trauma for surgical residents. Journal of Minnesota Medicine. Pages 14-16. May/June 2022.Commentaries, Editorials and Letters
2021
Comparison of Visual Abstract vs #BetterPoster Style for Surgery Research Presentations
Zolfaghari E, Kuehne A, Wang Q, Tignanelli C, Ingraham N. Comparison of Visual Abstract vs #BetterPoster Style for Surgery Research Presentations. Journal Of The American College Of Surgeons 2021, 233: s214. DOI: 10.1016/j.jamcollsurg.2021.07.441.Peer-Reviewed Original ResearchNeed for Emergent Intervention within 6 Hours: A Novel Prediction Model for Hospital Trauma Triage
Morris R, Karam BS, Zolfaghari EJ, Chen B, Kirsh T, Tourani R, Milia DJ, Napolitano L, de Moya M, Conterato M, Aliferis C, Ma S, Tignanelli C. Need for Emergent Intervention within 6 Hours: A Novel Prediction Model for Hospital Trauma Triage. Prehospital Emergency Care 2021, 26: 556-565. PMID: 34313534, DOI: 10.1080/10903127.2021.1958961.Peer-Reviewed Original ResearchMorbidity and Mortality Trends of Pancreatitis: An Observational Study
Ingraham NE, King S, Proper J, Siegel L, Zolfaghari EJ, Murray TA, Vakayil V, Sheka A, Feng R, Guzman G, Roy SS, Muddappa D, Usher MG, Chipman JG, Tignanelli CJ, Pendleton KM. Morbidity and Mortality Trends of Pancreatitis: An Observational Study. Surgical Infections 2021, 22: 1021-1030. PMID: 34129395, PMCID: PMC8851213, DOI: 10.1089/sur.2020.473.Peer-Reviewed Original ResearchConceptsState Inpatient DatabasesAcute pancreatitisGallbladder diseaseHealthcare costsMortality rateUtilization Project State Inpatient DatabasesIncidence of pancreatitisInpatient mortality rateCrude mortality rateHospital-based databaseLarge hospital-based databaseHospital-level dataHospital mortalityInpatient mortalityPatient demographicsMedian ageInpatient DatabaseMedian lengthEndoscopic interventionAdmission yearDecreased oddsObservational studyPancreatitisSurgical providersMedical providersCharacterizing COVID-19 clinical phenotypes and associated comorbidities and complication profiles
Lusczek ER, Ingraham NE, Karam BS, Proper J, Siegel L, Helgeson ES, Lotfi-Emran S, Zolfaghari EJ, Jones E, Usher MG, Chipman JG, Dudley RA, Benson B, Melton GB, Charles A, Lupei MI, Tignanelli CJ. Characterizing COVID-19 clinical phenotypes and associated comorbidities and complication profiles. PLOS ONE 2021, 16: e0248956. PMID: 33788884, PMCID: PMC8011766, DOI: 10.1371/journal.pone.0248956.Peer-Reviewed Original ResearchConceptsCOVID-19 patientsClinical phenotypePhenotype IIIClinical outcomesCOVID-19 clinical phenotypesHours of admissionPhenotype IHazard of deathCoronavirus disease 2019Specific clinical phenotypesCOVID-19 phenotypesHospital complicationsRespiratory comorbiditiesPatient comorbiditiesDifferent comorbiditiesComplication profilePatient populationAdmission characteristicsMultivariable modelRetrospective analysisDisease 2019ComorbiditiesTrial designPatientsClinical practice
2020
mTOR inhibition in COVID‐19: A commentary and review of efficacy in RNA viruses
Karam BS, Morris RS, Bramante CT, Puskarich M, Zolfaghari EJ, Lotfi‐Emran S, Ingraham NE, Charles A, Odde DJ, Tignanelli CJ. mTOR inhibition in COVID‐19: A commentary and review of efficacy in RNA viruses. Journal Of Medical Virology 2020, 93: 1843-1846. PMID: 33314219, PMCID: PMC8159020, DOI: 10.1002/jmv.26728.Peer-Reviewed Original ResearchConceptsAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSyndrome coronavirus 2 infectionCoronavirus 2 infectionReview of efficacyCoronavirus disease 2019Modulation of mTORSARS-CoV-2RNA virusesDisease 2019Recent evidence pointsMTOR inhibitorsViral infectionMTOR inhibitionMTOR pathwayMammalian targetRapamycin (mTOR) pathwayNumerous RNA virusesVirus growthCOVID-19MTOR resultsInfectionCurrent literatureHighlight evidenceEvidence pointsIncidence and Profile of Severe Cycling Injuries After Bikeway Infrastructure Changes.
Goerke D, Zolfaghari E, Marek AP, Endorf FW, Nygaard RM. Incidence and Profile of Severe Cycling Injuries After Bikeway Infrastructure Changes. Journal Of Community Health 2020, 45: 542-549. PMID: 31686373, PMCID: PMC7223060, DOI: 10.1007/s10900-019-00773-z.Peer-Reviewed Original Research
2019
An Intraocular Pressure Predictive of High-risk Histopathologic Features in Group E Retinoblastoma Eyes
Kim ME, Shah S, Zolfaghari E, Jubran R, Reid MW, Kim JW, Berry JL. An Intraocular Pressure Predictive of High-risk Histopathologic Features in Group E Retinoblastoma Eyes. International Ophthalmology Clinics 2019, 59: 77-86. PMID: 30908281, PMCID: PMC6681901, DOI: 10.1097/iio.0000000000000265.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolEye EnucleationFemaleFollow-Up StudiesHumansInfantIntraocular PressureMagnetic Resonance ImagingMaleMiddle AgedNeoplasm StagingPredictive Value of TestsPrognosisRetinal NeoplasmsRetinoblastomaRetrospective StudiesRisk FactorsYoung Adult
2018
Iris Hypoplasia as the Presenting Sign of Retinoblastoma in a Child With a 13q Deletion.
Shah S, Koban Y, Le BHA, Bechtold M, Zolfaghari E, Kim JW, Berry JL. Iris Hypoplasia as the Presenting Sign of Retinoblastoma in a Child With a 13q Deletion. Journal Of Pediatric Ophthalmology & Strabismus 2018, 55: e10-e13. PMID: 29684226, PMCID: PMC7444716, DOI: 10.3928/01913913-20180215-02.Peer-Reviewed Original ResearchChromosome DeletionChromosome DisordersChromosomes, Human, Pair 13Diagnosis, DifferentialDNA Mutational AnalysisDNA, NeoplasmFemaleFluorescein AngiographyFundus OculiHumansInfantIrisIris DiseasesMagnetic Resonance ImagingMutationPigmentation DisordersRetinoblastomaRetinoblastoma Binding ProteinsTomography, Optical CoherenceUbiquitin-Protein Ligases
2017
Lack of correlation between age at diagnosis and RB1 mutations for unilateral retinoblastoma: the importance of genetic testing
Berry JL, Lewis L, Zolfaghari E, Green S, Le BHA, Lee TC, Murphree AL, Kim JW, Jubran R. Lack of correlation between age at diagnosis and RB1 mutations for unilateral retinoblastoma: the importance of genetic testing. Ophthalmic Genetics 2017, 39: 408-410. PMID: 29286867, PMCID: PMC7446179, DOI: 10.1080/13816810.2017.1420807.Peer-Reviewed Original ResearchPotential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma.
Berry JL, Xu L, Murphree AL, Krishnan S, Stachelek K, Zolfaghari E, McGovern K, Lee TC, Carlsson A, Kuhn P, Kim JW, Cobrinik D, Hicks J. Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma. JAMA Ophthalmology 2017, 135: 1221-1230. PMID: 29049475, PMCID: PMC5710399, DOI: 10.1001/jamaophthalmol.2017.4097.Peer-Reviewed Original ResearchConceptsTumor-derived DNACell-free DNARB eyesIntravitreous injectionAqueous humorAH samplesCopy number variationsSalvage therapyRB1 mutationsTumor biopsiesNumber variationsTertiary care hospitalCase series studyDNA copy number variationsDNA copy number alterationsCopy number variation profilesHigh-sensitivity kitChromosomal copy number variationsTumor DNA fractionPolymerase chain reaction primersWhole-genome sequencingPrimary enucleationCare hospitalDisease courseNumber variation profilesRabbit model of ocular indirect photodynamic therapy using a retinoblastoma xenograft
Kim JW, Jacobsen B, Zolfaghari E, Ferrario A, Chevez-Barrios P, Berry JL, Lee DK, Rico G, Madi I, Rao N, Stachelek K, Wang LC, Gomer C. Rabbit model of ocular indirect photodynamic therapy using a retinoblastoma xenograft. Graefe's Archive For Clinical And Experimental Ophthalmology 2017, 255: 2363-2373. PMID: 28971251, DOI: 10.1007/s00417-017-3805-8.Peer-Reviewed Original ResearchConceptsRetinoblastoma xenograftsRabbit retinaPhotodynamic therapyLaser delivery systemTreatment of retinoblastomaPre-clinical studiesPhase 1Intraocular retinoblastomaIntravenous verteporfinRetinal scarsSubretinal tumorsDelivery systemRetinal damageRight eyeHistopathologic examinationOcular toxicityTumor necrosisOcular damageControl rabbitsTreatment durationRabbit modelVerteporfinWavelength diode laserThermal burnsPDT treatmentAtypical Retinal Pigment Epithelial Hyperplasia and Glial Proliferation Masquerading as Progressive Recurrent Retinoblastoma: A Case Report Review and Clinicopathologic Correlation
Zolfaghari E, Kim JW, Krishnan S, Chévez-Barrios P, Berry JL. Atypical Retinal Pigment Epithelial Hyperplasia and Glial Proliferation Masquerading as Progressive Recurrent Retinoblastoma: A Case Report Review and Clinicopathologic Correlation. Ocular Oncology And Pathology 2017, 4: 116-121. PMID: 30320092, PMCID: PMC6167681, DOI: 10.1159/000479741.Peer-Reviewed Original ResearchLaser therapyFocal recurrenceClinicopathologic correlationScar recurrenceRPE hyperplasiaRetinal pigment epithelium hyperplasiaRetinal pigment epithelial hyperplasiaRetrospective case reviewCase report reviewSporadic bilateral retinoblastomaActive retinoblastomaConsolidative therapyConsolidative treatmentRetinal opacificationProgressive lesionsGlial proliferationPremature maleWhite lesionsEpithelial hyperplasiaRecurrent retinoblastomaBilateral retinoblastomaEpithelium hyperplasiaGliosisRecurrenceLocal controlLong‐term outcomes of Group D retinoblastoma eyes during the intravitreal melphalan era
Berry JL, Shah S, Bechtold M, Zolfaghari E, Jubran R, Kim JW. Long‐term outcomes of Group D retinoblastoma eyes during the intravitreal melphalan era. Pediatric Blood & Cancer 2017, 64 PMID: 28646513, DOI: 10.1002/pbc.26696.Peer-Reviewed Original ResearchConceptsGroup D eyesGroup D retinoblastoma eyesD eyesSystemic chemoreductionIntravitreal melphalanSalvage rateRetinoblastoma eyesIntravitreal melphalan injectionRetrospective chart reviewOverall salvage ratePrimary outcome measurementLong-term outcomesExternal beam radiationOcular salvageSalvage therapyVitreous seedsChart reviewGlobe salvageIntravitreal injectionKaplan-MeierTreatment modalitiesTumor recurrenceMelphalan injectionOutcome measurementsMelphalanNot All Seeds Are Created Equal: Seed Classification Is Predictive of Outcomes in Retinoblastoma
Berry JL, Bechtold M, Shah S, Zolfaghari E, Reid M, Jubran R, Kim JW. Not All Seeds Are Created Equal: Seed Classification Is Predictive of Outcomes in Retinoblastoma. Ophthalmology 2017, 124: 1817-1825. PMID: 28655537, DOI: 10.1016/j.ophtha.2017.05.034.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, AlkylatingAntineoplastic Combined Chemotherapy ProtocolsCarboplatinChildChild, PreschoolCryotherapyEtoposideFemaleFollow-Up StudiesHumansInfantInfusions, IntravenousIntravitreal InjectionsLaser CoagulationMaleMelphalanNeoplasm SeedingRetinal NeoplasmsRetinoblastomaRetrospective StudiesSalvage TherapyVincristineVitreous BodyConceptsIntra-arterial chemotherapyIntravitreal melphalanIntravenous chemotherapyVitreous seedingSalvage rateRetrospective reviewIVM injectionsOverall globe salvage ratePrimary intra-arterial chemotherapyGlobe salvage rateNonrandomized retrospective reviewOutcome of retinoblastomaRecurrent vitreous seedingPrimary outcome measureActive retinoblastomaVitreous seedsGlobe salvageIntravitreal chemotherapySingle centerIntravitreal injectionMore injectionsGrade 3Outcome measuresSecondary measuresEffective treatmentClinical Significance of Optic Nerve Enhancement on Magnetic Resonance Imaging in Enucleated Retinoblastoma Patients
Kim JW, Madi I, Lee R, Zolfaghari E, Jubran R, Lee TC, Murphree AL, Berry JL. Clinical Significance of Optic Nerve Enhancement on Magnetic Resonance Imaging in Enucleated Retinoblastoma Patients. Ophthalmology Retina 2017, 1: 369-374. PMID: 31047563, PMCID: PMC7448757, DOI: 10.1016/j.oret.2017.03.013.Peer-Reviewed Original ResearchOptic nerve enhancementAbnormal MRI findingsOptic nerve invasionNerve enhancementOptic nerveMRI scansNerve invasionMRI findingsClinical significanceRetinoblastoma patientsMagnetic resonance imaging (MRI) findingsPostoperative contrast enhancementTransected optic nerveContrast enhancementAbnormal contrast enhancementRetrospective chart reviewPostoperative MRI scansPrimary outcome measureResonance Imaging FindingsLast clinical followRadiographic grading systemMagnetic resonance imagingPostoperative enhancementPreoperative chemotherapyChart reviewTreatment Outcomes of Focal Laser Consolidation during Chemoreduction for Group B Retinoblastoma
Kim JW, Aziz HA, McGovern K, Zolfaghari E, Jubran RF, Murphree AL, Berry JL. Treatment Outcomes of Focal Laser Consolidation during Chemoreduction for Group B Retinoblastoma. Ophthalmology Retina 2017, 1: 361-368. PMID: 31047562, PMCID: PMC7448755, DOI: 10.1016/j.oret.2017.01.014.Peer-Reviewed Original ResearchGlobe salvage rateGroup B tumorsTumor sizeB tumorsChorioretinal scarsSalvage rateTreatment outcomesPosterior fundusSingle-institution retrospective chart reviewScar sizeOverall globe salvage rateInitial laser treatmentMedian percent reductionRetrospective chart reviewGroup B eyesEnd of treatmentVertical diameterOriginal tumor sizeFinal scar sizeAssociation of timingLaser treatmentPerifoveal lesionsSystemic chemoreductionSystemic chemotherapyChart reviewOptic Nerve Obscuration in Retinoblastoma: A Risk Factor for Optic Nerve Invasion
Berry JL, Zolfaghari E, Chen A, Murphree AL, Jubran R, Kim JW. Optic Nerve Obscuration in Retinoblastoma: A Risk Factor for Optic Nerve Invasion. Ocular Oncology And Pathology 2017, 3: 283-291. PMID: 29344482, PMCID: PMC5757559, DOI: 10.1159/000464468.Peer-Reviewed Original ResearchOptic nerve invasionNerve invasionAdvanced retinoblastomaOptic nervePostlaminar optic nerve invasionPoor prognostic signPostlaminar invasionSalvage therapySalvage groupPrimary enucleationGlobe salvageRetrospective reviewPrognostic signRisk factorsIntraocular tumorsHistopathologic analysisSmall cohortNervePatientsDiagnosisRetinoblastomaEyesSecond groupInvasionTreatment
2016
Risk of metastasis and orbital recurrence in advanced retinoblastoma eyes treated with systemic chemoreduction versus primary enucleation
Berry JL, Kogachi K, Aziz HA, McGovern K, Zolfaghari E, Murphree AL, Jubran R, Kim JW. Risk of metastasis and orbital recurrence in advanced retinoblastoma eyes treated with systemic chemoreduction versus primary enucleation. Pediatric Blood & Cancer 2016, 64: e26270. PMID: 28221729, PMCID: PMC7034314, DOI: 10.1002/pbc.26270.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Combined Chemotherapy ProtocolsCarboplatinCombined Modality TherapyEtoposideEye EnucleationFemaleFollow-Up StudiesHumansInfantMaleNeoplasm Recurrence, LocalNeoplasm StagingOrbital NeoplasmsPrognosisRetinal NeoplasmsRetinoblastomaRetrospective StudiesRisk FactorsSalvage TherapyVincristineConceptsPrimary enucleation groupSystemic chemoreductionHigh-risk pathologyMetastatic diseaseOrbital recurrencePrimary enucleationAdvanced retinoblastomaEnucleation groupTreatment failureHigh-risk pathologic featuresChildren's Hospital Los AngelesPrimary outcome measureRisk of metastasisSalvage therapySecondary enucleationRetrospective reviewE retinoblastomaMedian timePathologic featuresRetinoblastoma eyesTreatment modalitiesPoor responseOutcome measuresChemoreductionSubsequent enucleation