2023
Pulmonary Artery Catheter Use and Mortality in the Cardiac Intensive Care Unit
Kadosh B, Berg D, Bohula E, Park J, Baird-Zars V, Alviar C, Alzate J, Barnett C, Barsness G, Burke J, Chaudhry S, Daniels L, DeFilippis A, Delicce A, Fordyce C, Ghafghazi S, Gidwani U, Goldfarb M, Katz J, Keeley E, Kenigsberg B, Kontos M, Lawler P, Leibner E, Menon V, Metkus T, Miller P, O'Brien C, Papolos A, Prasad R, Shah K, Sinha S, Snell R, So D, Solomon M, Ternus B, Teuteberg J, Toole J, van Diepen S, Morrow D, Roswell R. Pulmonary Artery Catheter Use and Mortality in the Cardiac Intensive Care Unit. JACC Heart Failure 2023, 11: 903-914. PMID: 37318422, PMCID: PMC10527413, DOI: 10.1016/j.jchf.2023.04.007.Peer-Reviewed Original ResearchMeSH KeywordsCathetersHeart FailureHospital MortalityHospitalizationHumansIntensive Care UnitsPulmonary ArteryConceptsCardiac intensive care unitPulmonary artery catheterUse of PACHospital mortalityCare unitPAC useCardiac patientsCritical Care Cardiology Trials NetworkPulmonary artery catheter usePatient-level factorsIll cardiac patientsIntensive care unitMechanical circulatory supportCardiac critical careAppropriate useCardiogenic etiologyAdmission diagnosisShock patientsCatheter useArtery catheterCICU admissionHeart failureRandomized trialsCirculatory supportCritical careThe Time Is Now to Investigate Ventilator Settings in Acute Cardiovascular Patients ∗
Miller P, Abrams D. The Time Is Now to Investigate Ventilator Settings in Acute Cardiovascular Patients ∗. JACC Heart Failure 2023, 11: 969-971. PMID: 37204364, PMCID: PMC10191154, DOI: 10.1016/j.jchf.2023.04.005.Commentaries, Editorials and LettersExposure to Arterial Hyperoxia During Extracorporeal Membrane Oxygenator Support and Mortality in Patients With Cardiogenic Shock
Jentzer J, Miller P, Alviar C, Yalamuri S, Bohman J, Tonna J. Exposure to Arterial Hyperoxia During Extracorporeal Membrane Oxygenator Support and Mortality in Patients With Cardiogenic Shock. Circulation Heart Failure 2023, 16: e010328. PMID: 36871240, PMCID: PMC10121893, DOI: 10.1161/circheartfailure.122.010328.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenator supportMembrane oxygenator supportHospital mortalityCardiogenic shockVenoarterial ECMOSevere hyperoxiaMild hyperoxiaHigher PaO2Extracorporeal Life Support Organization registryHigher arterial partial pressureHours of ECMOVenoarterial ECMO supportMultivariable logistic regressionArterial partial pressureClinical trial dataAcid-base statusArterial hyperoxiaExtracorporeal CPRRegistry patientsECMO supportAirway pressureNormal PaO2Ventilatory statusClinical variablesCS patients
2021
Association between Respiratory Failure and Clinical Outcomes in Patients with Acute Heart Failure: Analysis of 5 Pooled Clinical Trials
Miller PE, Van Diepen S, Metkus TS, Alviar CL, Rayner-Hartley E, Rathwell S, Katz JN, Ezekowitz J, Desai NR, Ahmad T. Association between Respiratory Failure and Clinical Outcomes in Patients with Acute Heart Failure: Analysis of 5 Pooled Clinical Trials. Journal Of Cardiac Failure 2021, 27: 602-606. PMID: 33556546, PMCID: PMC8527461, DOI: 10.1016/j.cardfail.2021.01.018.Peer-Reviewed Original ResearchConceptsAcute heart failureBaseline ejection fractionMechanical ventilationRespiratory failureHeart failureClinical trialsClinical outcomesHF etiologyHF rehospitalizationEjection fractionAcute HF admissionBaseline diabetes mellitusHF clinical trialsMechanical ventilation groupMechanical ventilation useProportion of patientsChronic lung diseaseMultivariable logistic regressionOriginal clinical trialsCause mortalityHF admissionsIndex hospitalizationMultivariable adjustmentSmoking historyVentilation group
2019
Clinical Implications of Respiratory Failure in Patients Receiving Durable Left Ventricular Assist Devices for End-Stage Heart Failure
Miller PE, Caraballo C, Ravindra NG, Mezzacappa C, McCullough M, Gruen J, Levin A, Reinhardt S, Ali A, Desai NR, Ahmad T. Clinical Implications of Respiratory Failure in Patients Receiving Durable Left Ventricular Assist Devices for End-Stage Heart Failure. Circulation Heart Failure 2019, 12: e006369. PMID: 31707800, DOI: 10.1161/circheartfailure.119.006369.Peer-Reviewed Original ResearchMeSH KeywordsAgedDisease ProgressionFemaleFrailtyHealth StatusHeart FailureHeart-Assist DevicesHumansIntubation, IntratrachealLungMaleMiddle AgedProsthesis DesignQuality of LifeRecovery of FunctionRegistriesRespiratory InsufficiencyRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeVentricular Function, LeftConceptsMechanically Assisted Circulatory Support profile 1 patientsVentricular assist device implantationProfile 1 patientsAssist device implantationRespiratory failureInteragency RegistryLVAD implantationCirculatory supportDevice implantationMechanically Assisted Circulatory Support profile 1Right ventricular assist device implantationLeft ventricular assist device implantationAdvanced heart failure patientsEnd-stage heart failureMechanically Assisted Circulatory SupportAdvanced heart failure populationHeart failure populationHeart failure patientsLandmark clinical trialsMechanical circulatory supportContinuous-flow LVADVentricular assist devicePostimplant complicationsFailure patientsLVAD placementNational Trends in Incidence and Outcomes of Patients With Heart Failure Requiring Respiratory Support
Miller PE, Patel S, Saha A, Guha A, Pawar S, Poojary P, Ratnani P, Chan L, Kamholz SL, Alviar CL, van Diepen S, Nasir K, Ahmad T, Nadkarni GN, Desai NR. National Trends in Incidence and Outcomes of Patients With Heart Failure Requiring Respiratory Support. The American Journal Of Cardiology 2019, 124: 1712-1719. PMID: 31585698, DOI: 10.1016/j.amjcard.2019.08.033.Peer-Reviewed Original ResearchConceptsInvasive mechanical ventilationUse of NIVRespiratory support strategiesNoninvasive ventilationHeart failureHospital mortalityRespiratory supportOutcomes of patientsNational Inpatient SampleLength of stayHF hospitalizationIMV groupHF patientsNIV groupRespiratory failureMechanical ventilationHospital chargesInpatient SamplePrimary diagnosisHospital costsMedical complexityPatientsSupport strategiesStudy periodMortalityAcute Decompensated Heart Failure Complicated by Respiratory Failure
Miller PE, van Diepen S, Ahmad T. Acute Decompensated Heart Failure Complicated by Respiratory Failure. Circulation Heart Failure 2019, 12: e006013. PMID: 31030542, DOI: 10.1161/circheartfailure.119.006013.Commentaries, Editorials and Letters
2018
Positive Pressure Ventilation in the Cardiac Intensive Care Unit
Alviar CL, Miller PE, McAreavey D, Katz JN, Lee B, Moriyama B, Soble J, van Diepen S, Solomon MA, Morrow DA, Group A. Positive Pressure Ventilation in the Cardiac Intensive Care Unit. Journal Of The American College Of Cardiology 2018, 72: 1532-1553. PMID: 30236315, PMCID: PMC11032173, DOI: 10.1016/j.jacc.2018.06.074.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsContemporary cardiac intensive care unitsPositive pressure ventilationInvasive positive pressure ventilationCardiac intensive care unitIntensive care unitCare unitPressure ventilationNoninvasive positive pressure ventilationMechanical positive pressure ventilationCardiogenic pulmonary edemaProportion of patientsManagement of patientsRisk of complicationsMechanical circulatory supportComplex patient populationRight ventricular physiologyCICU mortalityCardiogenic shockRespiratory failurePulmonary edemaCirculatory supportCardiac arrestPatient populationVentricular physiologyMedical complexity
2016
Angiotensin II antagonism is associated with reduced risk for gastrointestinal bleeding caused by arteriovenous malformations in patients with left ventricular assist devices
Houston BA, Schneider AL, Vaishnav J, Cromwell DM, Miller PE, Faridi KF, Shah A, Sciortino C, Whitman G, Tedford RJ, Stevens GR, Judge DP, Russell SD, Rouf R. Angiotensin II antagonism is associated with reduced risk for gastrointestinal bleeding caused by arteriovenous malformations in patients with left ventricular assist devices. The Journal Of Heart And Lung Transplantation 2016, 36: 380-385. PMID: 28169115, DOI: 10.1016/j.healun.2016.12.016.Peer-Reviewed Original ResearchConceptsLeft ventricular assist deviceGastrointestinal bleedingAngiotensin II antagonismARB therapyVascular endothelial growth factorArteriovenous malformationsVentricular assist deviceAssist deviceAngiotensin receptor blocker therapyContinuous-flow Left Ventricular Assist DevicesAssociation of ACEIReceptor blocker therapyInternational normalized ratioRegression hazard modelGastrointestinal arteriovenous malformationsJohns Hopkins HospitalLogistic regression analysisRisk of AVMAngiotensin II SignalingEndothelial growth factorBlocker therapyRenal functionAdult patientsBlood pressureCardiomyopathy etiology
2014
A Patient With Systolic Dysfunction and an Alternating Axis
Miller PE, Scholten EL, Desai CS, Tedford RJ. A Patient With Systolic Dysfunction and an Alternating Axis. JAMA Internal Medicine 2014, 174: 2027-2028. PMID: 25347012, DOI: 10.1001/jamainternmed.2014.5452.Peer-Reviewed Case Reports and Technical Notes