2024
Early Serial Assessment of Aggregate Vasoactive Support and Mortality in Cardiogenic Shock: Insights From the Critical Care Cardiology Trials Network Registry
Patel S, Berg D, Bohula E, Baird-Zars V, Barsness G, Chaudhry S, Chonde M, Cooper H, Ginder C, Jentzer J, Kontos M, Miller P, Newby L, O’Brien C, Park J, Pierce M, Pisani B, Potter B, Shah K, Teuteberg J, Katz J, van Diepen S, Morrow D. Early Serial Assessment of Aggregate Vasoactive Support and Mortality in Cardiogenic Shock: Insights From the Critical Care Cardiology Trials Network Registry. Circulation Heart Failure 2024, 17: e011736. PMID: 38587438, DOI: 10.1161/circheartfailure.124.011736.Peer-Reviewed Original ResearchVasoactive-inotropic scoreCardiac intensive care unitVasoactive supportCardiogenic shockGradient of riskMechanical circulatory supportPatients admitted with CSCardiac intensive care unit admissionClinical decision-makingCritical Care Cardiology Trials NetworkIntensive care unitSCAI stagesNetwork registryCare unitTrials NetworkSOFA scoreMulticenter registryPrognostic associationMortalitySerial assessmentCirculatory supportSupportEarly changesScoresPatientsPropofol vs etomidate for induction prior to invasive mechanical ventilation in patients with acute myocardial infarction
Thomas A, Banna S, Shahu A, Ali T, Schenck C, Patel B, Notarianni A, Phommalinh M, Kochar A, Heck C, van Diepen S, Miller P. Propofol vs etomidate for induction prior to invasive mechanical ventilation in patients with acute myocardial infarction. American Heart Journal 2024, 272: 116-125. PMID: 38554762, DOI: 10.1016/j.ahj.2024.03.013.Peer-Reviewed Original ResearchConceptsAssociated with lower mortalityAcute myocardial infarctionInvasive mechanical ventilationLower mortalityUS national databaseClinical Data BaseMyocardial infarctionIll patient populationLength of stayCritically ill patient populationIn-hospital mortalityInverse probability treatmentOptimal induction agentInduction agentNational databaseClinical outcomesMechanical ventilationProbability treatmentPropensity weightingPatient populationRandomized trialsMortalityUtilization of propofolVentilator daysPropofol group
2022
Staffing models in the cardiac intensive care unit
Quien M, Thomas A, Ludmir J, Miller PE. Staffing models in the cardiac intensive care unit. Current Opinion In Critical Care 2022, 28: 453-459. PMID: 35757936, DOI: 10.1097/mcc.0000000000000958.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiac intensive care unitIntensive care unitCare unitContemporary cardiac intensive care unitsModern cardiac intensive care unitMechanical circulatory supportSick patient populationFuture multicenter studiesStaffing modelsPreponderance of dataShock teamRespiratory failureIll patientsCirculatory supportMulticenter studyCardiac arrestPatient populationCardiac intensivistsIll populationMortalityRecent evidenceIntensivistsPatientsRecent dataPopulationRelation of Ischemic Heart Disease to Outcomes in Patients With Acute Respiratory Distress Syndrome
Biondi M, Jain S, Fuery M, Thomas A, Ali T, Alviar CL, Desai NR, Miller PE. Relation of Ischemic Heart Disease to Outcomes in Patients With Acute Respiratory Distress Syndrome. The American Journal Of Cardiology 2022, 176: 24-29. PMID: 35606175, DOI: 10.1016/j.amjcard.2022.04.034.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseVentilator-free daysHeart diseaseHistory of IHDImpact of IHDAcute respiratory distress syndromePredictors of mortalityRespiratory distress syndromeSeverity of illnessMultivariable logistic regressionMultivariable adjustmentSecondary outcomesDistress syndromeOrgan failurePrimary outcomeClinical outcomesIll subgroupStudy criteriaTreatment paradigmClinical trialsARDS severityPatientsHigh mortalityEnd pointMortality
2021
Mechanical ventilation at the time of heart transplantation and associations with clinical outcomes
Miller PE, Mullan CW, Chouairi F, Sen S, Clark KA, Reinhardt S, Fuery M, Anwer M, Geirsson A, Formica R, Rogers JG, Desai NR, Ahmad T. Mechanical ventilation at the time of heart transplantation and associations with clinical outcomes. European Heart Journal Acute Cardiovascular Care 2021, 10: 843-851. PMID: 34389855, PMCID: PMC8557439, DOI: 10.1093/ehjacc/zuab063.Peer-Reviewed Original ResearchConceptsHeart transplantationMechanical ventilationSingle-organ heart transplantationMedian waitlist timeOrgan Sharing databaseTime of transplantationMultivariable logistic regressionMultivariable adjustmentWaitlist timeClinical outcomesSharing databasePoor outcomeVentilated patientsUnited NetworkTemporary mechanical supportClinical acuityTransplantationPatientsPrevious dialysisLogistic regressionMortalityStrong associationReasonable outcomesOutcomesAssociationTransition From an Open to Closed Staffing Model in the Cardiac Intensive Care Unit Improves Clinical Outcomes
Miller PE, Chouairi F, Thomas A, Kunitomo Y, Aslam F, Canavan ME, Murphy C, Daggula K, Metkus T, Vallabhajosyula S, Carnicelli A, Katz JN, Desai NR, Ahmad T, Velazquez EJ, Brennan J. Transition From an Open to Closed Staffing Model in the Cardiac Intensive Care Unit Improves Clinical Outcomes. Journal Of The American Heart Association 2021, 10: e018182. PMID: 33412899, PMCID: PMC7955420, DOI: 10.1161/jaha.120.018182.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitIntensive care unitHospital mortalityCare unitCICU mortalityClinical outcomesModern cardiac intensive care unitSurgical intensive care unitTotal hospital chargesSeverity of illnessMultivariable logistic regressionCICU lengthMultivariable adjustmentRespiratory insufficiencyPrimary outcomeUnique admissionsHospital chargesCardiac arrestSubgroup analysisImproved outcomesMortalityLogistic regressionAdmissionClosed unitStaffing models
2019
National Trends in Incidence and Outcomes of Patients With Heart Failure Requiring Respiratory Support
Miller PE, Patel S, Saha A, Guha A, Pawar S, Poojary P, Ratnani P, Chan L, Kamholz SL, Alviar CL, van Diepen S, Nasir K, Ahmad T, Nadkarni GN, Desai NR. National Trends in Incidence and Outcomes of Patients With Heart Failure Requiring Respiratory Support. The American Journal Of Cardiology 2019, 124: 1712-1719. PMID: 31585698, DOI: 10.1016/j.amjcard.2019.08.033.Peer-Reviewed Original ResearchConceptsInvasive mechanical ventilationUse of NIVRespiratory support strategiesNoninvasive ventilationHeart failureHospital mortalityRespiratory supportOutcomes of patientsNational Inpatient SampleLength of stayHF hospitalizationIMV groupHF patientsNIV groupRespiratory failureMechanical ventilationHospital chargesInpatient SamplePrimary diagnosisHospital costsMedical complexityPatientsSupport strategiesStudy periodMortality
2016
Associations of Preimplant Red Blood Cell Distribution Width with Clinical Outcomes Among Individuals with Left Ventricular Assist Devices
Miller PE, Houston BA, Schneider AL, Bush AL, Whitman GJ, Stevens GR, Tedford RJ, Russell SD. Associations of Preimplant Red Blood Cell Distribution Width with Clinical Outcomes Among Individuals with Left Ventricular Assist Devices. ASAIO Journal 2016, 62: 677-683. PMID: 27798492, DOI: 10.1097/mat.0000000000000431.Peer-Reviewed Original ResearchConceptsRed blood cell distribution widthCell distribution widthVentricular assist deviceHeart failureClinical outcomesAssist deviceEnd-stage heart failureDistribution widthPost-LVAD complicationsContinuous-flow LVADProportional hazards modelPostimplant mortalityRDW tertilesGastrointestinal bleedAdverse eventsSecondary outcomesLaboratory variablesLVAD populationFull adjustmentPrognostic abilityHigh riskHazards modelBiologic mechanismsMortalityTertile