2023
Viral Interference During Influenza A–SARS-CoV-2 Coinfection of the Human Airway Epithelium and Reversal by Oseltamivir
Cheemarla N, Watkins T, Mihaylova V, Foxman E. Viral Interference During Influenza A–SARS-CoV-2 Coinfection of the Human Airway Epithelium and Reversal by Oseltamivir. The Journal Of Infectious Diseases 2023, 229: 1430-1434. PMID: 37722683, PMCID: PMC11095529, DOI: 10.1093/infdis/jiad402.Peer-Reviewed Original ResearchSARS-CoV-2 replicationSARS-CoV-2IAV replicationHuman airway epithelial culturesHuman airway epitheliumAirway epithelial culturesHost antiviral responseRobust interferon responseInfluenza infectionRespiratory virusesAirway epitheliumViral infectionAntiviral responseViral interferenceCoinfecting virusSimultaneous infectionHost cell defenseInterferon responseCoinfectionInfectionEpithelial culturesOseltamivirInfluenzaVirusCell defense
2021
Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics
Cheemarla NR, Watkins TA, Mihaylova VT, Wang B, Zhao D, Wang G, Landry ML, Foxman EF. Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics. Journal Of Experimental Medicine 2021, 218: e20210583. PMID: 34128960, PMCID: PMC8210587, DOI: 10.1084/jem.20210583.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngiotensin-Converting Enzyme 2Case-Control StudiesChemokine CXCL10COVID-19Disease SusceptibilityFemaleGene Expression ProfilingHost-Pathogen InteractionsHumansImmunity, InnateInterferonsMaleMiddle AgedNasopharynxPicornaviridae InfectionsSARS-CoV-2Viral LoadVirus ReplicationConceptsSARS-CoV-2 infectionSARS-CoV-2 exposureSARS-CoV-2Interferon-stimulated genesUpper respiratory tractRespiratory tractEarly SARS-CoV-2 infectionDynamic innate immune responseViral replicationSARS-CoV-2 replicationPatient nasopharyngeal samplesInnate immune responseLow infectious doseViral loadNasopharyngeal samplesImmune responseInfectious doseISG responseAntiviral responseInfection progressionViral transmissionLevel correlatesInfectionISG inductionInitial replication