2017
ΔN-Bcl-xL, a therapeutic target for neuroprotection
Park HA, Jonas EA. ΔN-Bcl-xL, a therapeutic target for neuroprotection. Neural Regeneration Research 2017, 12: 1791-1794. PMID: 29239317, PMCID: PMC5745825, DOI: 10.4103/1673-5374.219033.Peer-Reviewed Original ResearchΔN-BclNeuronal deathNeuronal viabilityMitochondrial dysfunctionPrimary hippocampal neuronsABT-737Excitotoxic injuryGlutamate toxicityHippocampal neuronsAnti-apoptotic proteinsTherapeutic targetB cellsPrimary neuronsNeuronal functionAcute productionNeuroprotectionAltered metabolismMitochondrial damageNeuronsCentral targetMitochondrial functionDysfunctionDeathMitochondrial anti-apoptotic proteinDependent effects
2013
PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage
Arena G, Gelmetti V, Torosantucci L, Vignone D, Lamorte G, De Rosa P, Cilia E, Jonas EA, Valente EM. PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage. Cell Death & Differentiation 2013, 20: 920-930. PMID: 23519076, PMCID: PMC3679455, DOI: 10.1038/cdd.2013.19.Peer-Reviewed Original ResearchConceptsBcl-xLMitochondrial depolarizationCell deathPro-autophagic protein Beclin-1Autosomal recessive Parkinson's diseaseBeclin-1Recessive Parkinson's diseaseAnti-apoptotic proteinsXL interactionMitochondrial kinaseProtein Beclin 1Mitochondrial traffickingMitochondrial homeostasisMitophagy pathwayBcl-xL.PINK1Functional linkCell survivalPathogenesis of PDNovel mechanismPINK1 genePathwayCleavageMitophagyParkinson's disease