2018
The Cholinergic System as a Treatment Target for Opioid Use Disorder
Jensen KP, DeVito EE, Yip S, Carroll KM, Sofuoglu M. The Cholinergic System as a Treatment Target for Opioid Use Disorder. CNS Drugs 2018, 32: 981-996. PMID: 30259415, PMCID: PMC6314885, DOI: 10.1007/s40263-018-0572-y.Peer-Reviewed Original ResearchConceptsCholinergic systemUse disordersTreatment targetsOpioid use disorder epidemicCentral nervous system functionTreatment of OUDEffects of acetylcholineOpioid use disorderTobacco use disorderNervous system functionOpioid medicationsDegrade acetylcholineCurrent treatmentOpioid overdosesPreclinical studiesMedicationsAcetylcholineCholinesterase inhibitorsAlzheimer's diseaseNew treatmentsAccidental deathGlobal healthTreatmentOUDDisease
2014
Toward empirical identification of a clinically meaningful indicator of treatment outcome: Features of candidate indicators and evaluation of sensitivity to treatment effects and relationship to one year follow up cocaine use outcomes
Carroll KM, Kiluk BD, Nich C, DeVito EE, Decker S, LaPaglia D, Duffey D, Babuscio TA, Ball SA. Toward empirical identification of a clinically meaningful indicator of treatment outcome: Features of candidate indicators and evaluation of sensitivity to treatment effects and relationship to one year follow up cocaine use outcomes. Drug And Alcohol Dependence 2014, 137: 3-19. PMID: 24556275, PMCID: PMC4042667, DOI: 10.1016/j.drugalcdep.2014.01.012.Peer-Reviewed Original Research
2012
Cognitive enhancement as a treatment for drug addictions
Sofuoglu M, DeVito EE, Waters AJ, Carroll KM. Cognitive enhancement as a treatment for drug addictions. Neuropharmacology 2012, 64: 452-463. PMID: 22735770, PMCID: PMC3445733, DOI: 10.1016/j.neuropharm.2012.06.021.Peer-Reviewed Original ResearchConceptsCognitive enhancementBehavioral interventionsExecutive inhibitory controlCognitive impairmentDrug addictionSelective cognitive functionsCurrent illicit drug usersPoor treatment retentionCognitive enhancing agentsSignificant cognitive impairmentSpecific behavioral interventionsChronic drug useCognitive remediationInhibitory controlMarijuana addictionCognitive enhancersBehavioral treatmentCognitive functionDrug use behaviorsMultiple addictionsSubstance usersTreatment retentionInhibition functionFuture researchUse behaviors