2013
Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism
DeVito EE, Meda SA, Jiantonio R, Potenza MN, Krystal JH, Pearlson GD. Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism. Neuropsychopharmacology 2013, 38: 1854-1863. PMID: 23584260, PMCID: PMC3746701, DOI: 10.1038/npp.2013.92.Peer-Reviewed Original ResearchConceptsAlcohol use measuresNeural correlatesFHP individualsImpulse controlHigher self-reported impulsivityGreater BOLD signalFHN groupSelf-reported impulsivityAlcohol useInferior frontal gyrusLeft anterior insulaUse measuresImpulsivity factorsAnterior insulaFrontal gyrusGreater activationImpulsivityAddictive disordersNeural systemsScanner measuresSuccessful inhibitionBOLD signalSex differencesBehavioral traitsAddiction
2012
Impaired inhibitory control in ‘internet addiction disorder’: A functional magnetic resonance imaging study
Dong G, DeVito EE, Du X, Cui Z. Impaired inhibitory control in ‘internet addiction disorder’: A functional magnetic resonance imaging study. Psychiatry Research 2012, 203: 153-158. PMID: 22892351, PMCID: PMC3650485, DOI: 10.1016/j.pscychresns.2012.02.001.Peer-Reviewed Original ResearchConceptsIAD groupMagnetic resonance imaging studyPrevalent mental health concernAddiction disordersResonance imaging studyFunctional magnetic resonance imaging studyPosterior cingulate cortexMental health concernsImpaired inhibitory controlHealthy controlsHealthy peersInternet addiction disorderCingulate cortexImaging studiesHealth concernDisordersNeurobiological underpinningsInhibitory controlResponse inhibitionNeural correlatesResponse inhibition processesPotential heterogeneityPresent studyGroupMemantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism
Jamadar S, DeVito EE, Jiantonio RE, Meda SA, Stevens MC, Potenza MN, Krystal JH, Pearlson GD. Memantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism. Psychopharmacology 2012, 222: 129-140. PMID: 22311382, PMCID: PMC3674025, DOI: 10.1007/s00213-011-2628-2.Peer-Reviewed Original ResearchConceptsNMDA receptor antagonistFamily historyFHN subjectsReceptor antagonistFHP subjectsN-methyl-D-aspartate receptor functionReceptor functionIdentical-appearing placeboEffects of memantineFMRI activityNMDA receptor functionCorrect rejectsSingle doseMemantineGo/No-Go taskSeparate daysTemporal regionsCingulate activation
2008
Methylphenidate improves response inhibition but not reflection–impulsivity in children with attention deficit hyperactivity disorder (ADHD)
DeVito EE, Blackwell AD, Clark L, Kent L, Dezsery AM, Turner DC, Aitken MR, Sahakian BJ. Methylphenidate improves response inhibition but not reflection–impulsivity in children with attention deficit hyperactivity disorder (ADHD). Psychopharmacology 2008, 202: 531. PMID: 18818905, PMCID: PMC2704617, DOI: 10.1007/s00213-008-1337-y.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderInformation Sampling TaskResponse inhibitionDeficit hyperactivity disorderHyperactivity disorderEducation-matched control groupPerformance of childrenForms of impulsivityStop-signal taskMeasures of impulsivityEffects of methylphenidateMulti-factorial constructADHD groupSignal taskImpulsivityPoor decisionsBehavioral symptomsMethylphenidateSampling tasksSame measuresPlacebo-controlled trialTaskChildrenImpairmentMeasures
2006
Impulsivity, reward sensitivity, and decision-making in subarachnoid hemorrhage survivors
SALMOND CH, DEVITO EE, CLARK L, MENON DK, CHATFIELD DA, PICKARD JD, KIRKPATRICK PJ, SAHAKIAN BJ. Impulsivity, reward sensitivity, and decision-making in subarachnoid hemorrhage survivors. Journal Of The International Neuropsychological Society 2006, 12: 697-706. PMID: 16961951, DOI: 10.1017/s135561770606084x.Peer-Reviewed Original ResearchConceptsSubarachnoid hemorrhage survivorsSAH survivorsComputerized decision-making taskAspects of impulsivityDecision-making taskDecision-making behaviorReward sensitivityComputerized tasksImpulsive respondingRisk-Taking BehaviorEmotional changesComplex deficitsIndividual's abilityPoor judgmentAnterior communicating arteryImpulsivityTaskNature of decisionDecision makingCommunicating arteryDaily livingSurvivorsArteryDiminished capacityAneurysms