Methylphenidate improves response inhibition but not reflection–impulsivity in children with attention deficit hyperactivity disorder (ADHD)
DeVito EE, Blackwell AD, Clark L, Kent L, Dezsery AM, Turner DC, Aitken MR, Sahakian BJ. Methylphenidate improves response inhibition but not reflection–impulsivity in children with attention deficit hyperactivity disorder (ADHD). Psychopharmacology 2008, 202: 531. PMID: 18818905, PMCID: PMC2704617, DOI: 10.1007/s00213-008-1337-y.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderInformation Sampling TaskResponse inhibitionDeficit hyperactivity disorderHyperactivity disorderEducation-matched control groupPerformance of childrenForms of impulsivityStop-signal taskMeasures of impulsivityEffects of methylphenidateMulti-factorial constructADHD groupSignal taskImpulsivityPoor decisionsBehavioral symptomsMethylphenidateSampling tasksSame measuresPlacebo-controlled trialTaskChildrenImpairmentMeasuresThe Effects of Methylphenidate on Decision Making in Attention-Deficit/Hyperactivity Disorder
DeVito EE, Blackwell AD, Kent L, Ersche KD, Clark L, Salmond CH, Dezsery AM, Sahakian BJ. The Effects of Methylphenidate on Decision Making in Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry 2008, 64: 636-639. PMID: 18504036, PMCID: PMC2577132, DOI: 10.1016/j.biopsych.2008.04.017.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildDecision MakingGamblingHumansMaleMethylphenidateNeuropsychological TestsConceptsAttention-deficit/hyperactivity disorderCambridge Gamble TaskADHD groupHyperactivity disorderDecision-making cognitionDecision-making deficitsEffects of methylphenidatePoor decision makingParent-reported symptomsHealthy age-matched control groupNeuropsychological markersEveryday behaviorStimulant medicationDisruptive behaviorPoor decisionsPoor judgmentBetting behaviorLittle empirical dataControl subjectsPlacebo sessionAge-matched control groupTaskDecision makingMethylphenidatePlacebo-controlled trial