Featured Publications
Habitual sleep duration and its relationship with cardiovascular health, healthcare costs, and resource utilization in a working population
Aneni E, Osondu C, Joseph J, Saeed G, Valero-Elizondo J, Veledar E, Nasir K. Habitual sleep duration and its relationship with cardiovascular health, healthcare costs, and resource utilization in a working population. Sleep Health 2022, 9: 77-85. PMID: 36371382, PMCID: PMC9991949, DOI: 10.1016/j.sleh.2022.10.001.Peer-Reviewed Original ResearchConceptsCardiovascular healthHabitual sleep durationSleep durationHealthcare expendituresHealthcare costsOptimal cardiovascular healthIdeal cardiovascular healthBaptist Health South FloridaHealthcare resource utilizationBody mass indexBetter cardiovascular healthMedical claims dataHours of sleepLower healthcare expendituresCVH metricsMore hoursBlood pressureMass indexMean ageEmergency roomCardiovascular diseaseHigher oddsHispanic ethnicityPhysical activityClaims dataLipoprotein Sub-Fractions by Ion-Mobility Analysis and Its Association with Subclinical Coronary Atherosclerosis in High-Risk Individuals
Aneni EC, Osondu CU, De La Cruz J, Martin SS, Blaha MJ, Younus A, Feldman T, Agatston AS, Veledar E, Nasir K. Lipoprotein Sub-Fractions by Ion-Mobility Analysis and Its Association with Subclinical Coronary Atherosclerosis in High-Risk Individuals. Journal Of Atherosclerosis And Thrombosis 2018, 26: 50-63. PMID: 30224606, PMCID: PMC6308270, DOI: 10.5551/jat.40741.Peer-Reviewed Original ResearchConceptsCoronary artery calcificationLipoprotein subfractionsCoronary atherosclerosisRisk of CACLipoprotein particlesLipoprotein subfraction analysisSubclinical coronary atherosclerosisBaptist Health South FloridaLarge LDL particlesHigh-risk personsHigh-risk populationHigh-risk individualsTriglyceride-rich lipoproteinsHigh-risk workersArtery calcificationIDL particlesMetabolic syndromeLipoprotein profileHDL lipoproteinsMean ageLipoprotein subclassesMedium LDLStudy populationRisk individualsVLDL particlesThe relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis
Osondu CU, Vo B, Oni ET, Blaha MJ, Veledar E, Feldman T, Agatston AS, Nasir K, Aneni EC. The relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis. Vascular Medicine 2017, 23: 9-20. PMID: 29243995, DOI: 10.1177/1358863x17725809.Peer-Reviewed Original ResearchConceptsCarotid intima-media thicknessAssociation of EDFlow-mediated dilationSubclinical cardiovascular diseaseCoronary artery calcificationErectile dysfunctionCardiovascular diseaseHigher carotid intima-media thicknessAnkle-brachial indexToe-brachial indexCVD risk assessmentIntima-media thicknessPulse wave velocityArtery calcificationEndothelial dysfunctionCVD mortalityMean ageVascular functionStudy qualityStudy populationAssessment QuestionnaireSystematic reviewDysfunctionPercentage point reductionMultiple databasesEstimates of Mortality Benefit From Ideal Cardiovascular Health Metrics: A Dose Response Meta‐Analysis
Aneni EC, Crippa A, Osondu CU, Valero‐Elizondo J, Younus A, Nasir K, Veledar E. Estimates of Mortality Benefit From Ideal Cardiovascular Health Metrics: A Dose Response Meta‐Analysis. Journal Of The American Heart Association 2017, 6: e006904. PMID: 29269350, PMCID: PMC5779012, DOI: 10.1161/jaha.117.006904.Peer-Reviewed Original ResearchConceptsIdeal cardiovascular healthIdeal CVH metricsPooled hazard ratioCVH metricsCardiovascular healthMortality benefitHazard ratioCardiovascular disease-related mortalityDose–response meta analysisStrong public health messageIdeal cardiovascular health metricsSubstantial mortality benefitCardiovascular health metricsCardiovascular disease mortalityLinear dose-response relationshipDisease-related mortalityPublic health messagesHazard ratio estimatesDose-response relationshipUnit increaseWeb of ScienceCause mortalityInternet literature searchDisease mortalityCardiovascular diseaseA Systematic Review of Internet-Based Worksite Wellness Approaches for Cardiovascular Disease Risk Management: Outcomes, Challenges & Opportunities
Aneni EC, Roberson LL, Maziak W, Agatston AS, Feldman T, Rouseff M, Tran TH, Blumenthal RS, Blaha MJ, Blankstein R, Al-Mallah MH, Budoff MJ, Nasir K. A Systematic Review of Internet-Based Worksite Wellness Approaches for Cardiovascular Disease Risk Management: Outcomes, Challenges & Opportunities. PLOS ONE 2014, 9: e83594. PMID: 24421894, PMCID: PMC3885454, DOI: 10.1371/journal.pone.0083594.Peer-Reviewed Original ResearchConceptsInternet-based programCardiovascular wellnessSystematic reviewCardiovascular disease risk managementCardiovascular health outcomesInclusion/exclusion criteriaPhysical activity outcomesSpecific disease entityWeb of ScienceCV healthRandomized trialsCochrane LibraryBlood glucoseDisease entityDisease risk managementPhysical activityExclusion criteriaRisk populationsHealth outcomesWellness interventionsPrevention programsActivity outcomesIntervention typeWellness approachBlue-collar workersThe Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve
Aneni E, Thorn S, Feher A, Hong Chen J, Sinusas A, Yaggi H, Miller E. The Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve. JACC Cardiovascular Imaging 2023, 16: 856-858. PMID: 36881426, PMCID: PMC10718199, DOI: 10.1016/j.jcmg.2022.11.024.Peer-Reviewed Original ResearchAtherosclerotic plaque in individuals without known cardiovascular disease but with established obstructive sleep apnea and at high risk of obstructive sleep apnea
Walia H, Khosla A, Saxena A, Aneni E, Ali S, Valero-Elizondo J, Cainzos-Achirica M, Feldman T, Fialkow J, Nasir K. Atherosclerotic plaque in individuals without known cardiovascular disease but with established obstructive sleep apnea and at high risk of obstructive sleep apnea. American Journal Of Preventive Cardiology 2023, 14: 100497. PMID: 37131984, PMCID: PMC10149201, DOI: 10.1016/j.ajpc.2023.100497.Peer-Reviewed Original ResearchObstructive sleep apneaCoronary plaquesHigh riskSleep apneaLower riskBerlin questionnaireRisk factorsCT angiographySignificant associationMultivariable logistic regression analysisCardiovascular risk factorsCVD risk factorsLarge U.S. cohortCoronary CT angiographyLogistic regression analysisPopulation-based sampleComposition of plaquesLogistic regression modelsOSA cohortOSA presenceCoronary atherosclerosisOSA severityOSA categoriesSubgroup analysisCardiovascular diseaseThe risk of cardiometabolic disorders in lean non-alcoholic fatty liver disease: A longitudinal study
Aneni E, Bittencourt M, Teng C, Cainzos-Achirica M, Osondu C, Soliman A, Al-Mallah M, Buddoff M, Parise E, Santos R, Nasir K. The risk of cardiometabolic disorders in lean non-alcoholic fatty liver disease: A longitudinal study. American Journal Of Preventive Cardiology 2020, 4: 100097. PMID: 34327473, PMCID: PMC8315654, DOI: 10.1016/j.ajpc.2020.100097.Peer-Reviewed Original ResearchLean non-alcoholic fatty liver diseaseNon-alcoholic fatty liver diseaseFatty liver diseaseAlcohol Use Disorders Identification TestLean individualsAtherogenic dyslipidemiaElevated glucoseElevated BPLiver diseaseFatty liverCardiovascular risk stratificationYoung asymptomatic individualsHealth promotion evaluationDisorders Identification TestAppropriate preventive measuresMedian followNAFLD individualsCardiometabolic consequencesCardiometabolic disordersRisk stratificationAsymptomatic individualsHigh riskBlood samplesAnthropometric measuresPopulation cohortBlood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk
Aneni EC, Oni ET, Martin SS, Blaha MJ, Agatston AS, Feldman T, Veledar E, Conçeicao RD, Carvalho JA, Santos RD, Nasir K. Blood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk. Journal Of Hypertension 2015, 33: 1207-1214. PMID: 25693058, DOI: 10.1097/hjh.0000000000000532.Peer-Reviewed Original ResearchConceptsNonobese hypertensive patientsPrevalence of NAFLDMetabolic risk factorsHypertensive patientsNormal BPRisk factorsHigh Blood Pressure classificationNonalcoholic fatty liver diseaseHealthy middle-aged menBlood pressure groupJoint National CommitteeDevelopment of hypertensionFatty liver diseaseYearly physical examinationMiddle-aged menBlood pressure classificationBP controlPrehypertensive patientsCardiometabolic riskCross-sectional relationshipBlood pressureNAFLD severityLiver diseaseNormotensive individualsPhysical examination
2024
Atrial Fibrillation: Prevalence and Association With Outcome in Patients With Stroke Undergoing Mechanical Thrombectomy in the United States
Otite F, Patel S, Hoffman H, Aneni E, Anikpezie N, Akano E, Wee C, Burke D, Albright K, Beutler T, Latorre J, Sonig A, Singla A, Morris N, Chaturvedi S, Khandelwal P. Atrial Fibrillation: Prevalence and Association With Outcome in Patients With Stroke Undergoing Mechanical Thrombectomy in the United States. Stroke Vascular And Interventional Neurology 2024, 4 DOI: 10.1161/svin.123.001248.Peer-Reviewed Original ResearchAcute ischemic strokeAF prevalenceJoinpoint regressionAtrial fibrillationIn-hospital deathIn-hospital outcomesMechanical thrombectomyDemographic subgroupsMultivariable-adjusted generalized linear modelsDemographic subgroups of patientsOdds of in-hospital deathCross-sectional studyNegative binomial regressionPrevalence of atrial fibrillationRoutine home dischargeNational Inpatient SampleAcute ischemic stroke populationAssociation of AFUnited StatesSubgroup of patientsHome dischargeBinomial regressionMultivariable adjustmentRacial subgroupsInpatient SampleAssociation between high risk of obstructive sleep apnea and inflammatory markers in a population sample of young and middle-aged adults in the Miami Heart Study.
Khosla A, Nasir K, Saxena A, Aneni E, Ali S, Valero-Elizondo J, Cainzos-Achirica M, Feldman T, Fialkow J, Walia H. Association between high risk of obstructive sleep apnea and inflammatory markers in a population sample of young and middle-aged adults in the Miami Heart Study. Journal Of Clinical Sleep Medicine 2024 PMID: 38975989, DOI: 10.5664/jcsm.11274.Peer-Reviewed Original ResearchHigh risk of obstructive sleep apneaRisk of obstructive sleep apneaObstructive sleep apneaHs-CRPCardiovascular disease risk factorsFree of cardiovascular diseaseInflammatory markersHigh riskCardiovascular diseaseIL-6Sleep apneaLow risk of obstructive sleep apneaTNF-aObstructive sleep apnea screeningLow riskRisk factorsLevels of inflammatory markersLevels of hs-CRPTNF-a levelsCVD-free participantsHeart StudyBerlin questionnaireIndividuals free of cardiovascular diseaseSubclinical inflammationPoisson regression analysisLinks Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes
Aneni E, Sinusas A, Emokpae M, Thorn S, Yaggi H, Miller E. Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes. Current Cardiology Reports 2024, 26: 723-734. PMID: 38806976, DOI: 10.1007/s11886-024-02072-z.Peer-Reviewed Original ResearchObstructive sleep apneaCoronary microvascular dysfunctionAbnormal myocardial blood flowSevere obstructive sleep apneaMyocardial flow reserveMyocardial blood flowSleep apneaModerate to severe obstructive sleep apneaAbnormal myocardial flow reserveRecent FindingsRecent studiesDisease-related outcomesBlood flow changesMyocardial blood flow changesCardiovascular disease-related outcomesMicrovascular dysfunctionClinical impactCPAPReviewRecent studiesStructural abnormalitiesCoronary microcirculationFindingsRecent studiesFlow reserveCardiac workBlood flowApneaTrends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York
Anuforo A, Aneni E, Akintoye E, Anikpezie N, Patel S, Soipe A, Olojakpoke E, Burke D, Latorre J, Khandelwal P, Chaturvedi S, Ovbiagele B, Otite F. Trends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York. Circulation 2024, 149: 1391-1393. PMID: 38648273, DOI: 10.1161/circulationaha.123.066921.Peer-Reviewed Original ResearchPlateauing atrial fibrillation burden in acute ischemic stroke admissions in the United States from 2010 to 2020
Otite F, Patel S, Aneni E, Lamikanra O, Wee C, Albright K, Burke D, Latorre J, Morris N, Anikpezie N, Singla A, Sonig A, Kamel H, Khandelwal P, Chaturvedi S. Plateauing atrial fibrillation burden in acute ischemic stroke admissions in the United States from 2010 to 2020. International Journal Of Stroke 2024, 19: 547-558. PMID: 38086764, DOI: 10.1177/17474930231222163.Peer-Reviewed Original ResearchAtrial fibrillationAIS hospitalizationsAF prevalenceJoinpoint regressionSerial cross-sectional studyAcute ischemic stroke admissionsStudy periodComorbid atrial fibrillationIschemic stroke preventionAtrial fibrillation burdenIschemic stroke admissionsSex-standardized prevalenceNational Inpatient SampleCross-sectional studySimilar aged menAge/sex groupsMen 40Stroke preventionOral anticoagulantsStroke admissionsWomen 40Inpatient SampleDiseases codesMen 18Hospitalization
2023
Demographic Disparities in the Incidence, Clinical Characteristics, and Outcome of Posterior Reversible Encephalopathy Syndrome in the United States
Otite F, Patel S, Anikpezie N, Hoffman H, Beutler T, Akano E, Aneni E, Lamikanra O, Osondu C, Wee C, Burke D, Albright K, Latorre J, Mejico L, Khandelwal P, Chaturvedi S. Demographic Disparities in the Incidence, Clinical Characteristics, and Outcome of Posterior Reversible Encephalopathy Syndrome in the United States. Neurology 2023, 101: e1554-e1559. PMID: 37487751, PMCID: PMC10585693, DOI: 10.1212/wnl.0000000000207604.Peer-Reviewed Original ResearchConceptsPosterior reversible encephalopathy syndromeNational Readmission DatabaseReversible encephalopathy syndromeEncephalopathy syndromeFemale patientsHispanic patientsMale patientsSex-standardized incidenceRetrospective cohort studyRace-specific incidenceSimilar demographic distributionState Inpatient DatabasesNon-Hispanic whitesIncident hospitalizationClinical characteristicsCohort studyFirst hospitalizationBlack patientsInpatient DatabasePatientsNew casesIncidenceStudy periodDemographic disparitiesHospitalizationAge- and Sex-Specific Trends in Medical Complications After Acute Ischemic Stroke in the United States
Ahmed R, Mhina C, Philip K, Patel S, Aneni E, Osondu C, Lamikanra O, Akano E, Anikpezie N, Albright K, Latorre J, Chaturvedi S, Otite F. Age- and Sex-Specific Trends in Medical Complications After Acute Ischemic Stroke in the United States. Neurology 2023, 100: e1282-e1295. PMID: 36599695, PMCID: PMC10033158, DOI: 10.1212/wnl.0000000000206749.Peer-Reviewed Original ResearchConceptsSex-specific prevalenceAIS admissionsNoninfectious complicationsAcute ischemic stroke hospitalizationsSerial cross-sectional studyPrevalence of UTIRisk of UTIAcute ischemic strokeNational Inpatient SampleNIH Stroke ScaleIschemic stroke hospitalizationsCross-sectional studyAge/sexSex-specific trendsHospital mortalityInfectious complicationsMultivariable adjustmentStroke ScaleCommon complicationIschemic strokeMechanical thrombectomyMedical complicationsComplication riskPE prevalenceStroke hospitalizations
2022
Trends in age and sex-specific prevalence of cancer and cancer subtypes in acute ischemic stroke from 2007-2019
Otite F, Somani S, Aneni E, Akano E, Patel S, Anikpezie N, Lamikanra O, Masoud H, Latorre J, Chaturvedi S, Mehndiratta P. Trends in age and sex-specific prevalence of cancer and cancer subtypes in acute ischemic stroke from 2007-2019. Journal Of Stroke And Cerebrovascular Diseases 2022, 31: 106818. PMID: 36323171, DOI: 10.1016/j.jstrokecerebrovasdis.2022.106818.Peer-Reviewed Original ResearchConceptsSex-specific prevalenceCancer prevalenceGenitourinary cancersAIS admissionsActive cancerGastrointestinal cancerMetastatic cancerSolid cancersPrimary central nervous system cancerRetrospective serial cross-sectional studyAcute ischemic stroke hospitalizationsSerial cross-sectional studyCentral nervous system cancerLung cancer prevalenceAcute ischemic strokeNational Inpatient SampleIschemic stroke hospitalizationsHead/neckNervous system cancersCommon solid cancersCross-sectional studyPrevalence of cancerCancer admissionsIschemic strokeStroke hospitalizationsCardiometabolic disorders, inflammation and the incidence of non-alcoholic fatty liver disease: A longitudinal study comparing lean and non-lean individuals
Aneni E, Saeed G, Bittencourt M, Cainzos-Achirica M, Osondu C, Budoff M, Parise E, Santos R, Nasir K. Cardiometabolic disorders, inflammation and the incidence of non-alcoholic fatty liver disease: A longitudinal study comparing lean and non-lean individuals. PLOS ONE 2022, 17: e0266505. PMID: 35385529, PMCID: PMC8985996, DOI: 10.1371/journal.pone.0266505.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseRisk of NAFLDElevated blood glucoseElevated blood pressureFatty liver diseaseBlood glucoseLean individualsBlood pressureCardiometabolic disordersPhysical inactivityWaist circumferenceLiver diseaseDevelopment of NAFLDHigh-sensitivity C-reactive proteinCardiovascular disease risk stratificationSensitivity C-reactive proteinCardiometabolic risk factorsAlcohol Use Disorders Identification TestC-reactive proteinMain exposure variableDisease risk stratificationHospital Israelita Albert EinsteinDisorders Identification TestAppropriate preventive measuresAtherogenic dyslipidemia
2021
Quantifying radiotracer activity on cardiac sympathetic imaging: Does it really matter?
Aneni EC, Sinusas AJ. Quantifying radiotracer activity on cardiac sympathetic imaging: Does it really matter? Journal Of Nuclear Cardiology 2021, 29: 426-429. PMID: 34341954, DOI: 10.1007/s12350-021-02738-z.Commentaries, Editorials and Letters
2020
Non-Alcoholic Fatty Liver Disease Modifies Serum Gamma-Glutamyl Transferase in Cigarette Smokers
Oni ET, Figueredo V, Aneni E, Veladar E, McEvoy JW, Blaha MJ, Blumenthal RS, Conceicao RD, Carvalho JAM, Santos RD, Nasir K. Non-Alcoholic Fatty Liver Disease Modifies Serum Gamma-Glutamyl Transferase in Cigarette Smokers. Journal Of Clinical Medicine Research 2020, 12: 472-482. PMID: 32849935, PMCID: PMC7430878, DOI: 10.14740/jocmr3932.Peer-Reviewed Original ResearchNon-alcoholic fatty liver diseaseGamma-glutamyl transferaseSerum gamma-glutamyl transferaseClinical cardiovascular diseaseHigh GGT levelsGGT levelsNAFLD statusOxidative stressAbsence of NAFLDPresence of NAFLDPrevalence of NAFLDFatty liver diseaseImpact of smokingCross-sectional associationsCV riskCardiovascular riskCurrent smokersCurrent smokingMultivariable adjustmentLiver diseaseCigarette smokersEffect modificationCardiovascular diseaseHealthy subjectsSmoking