Featured Publications
Habitual sleep duration and its relationship with cardiovascular health, healthcare costs, and resource utilization in a working population
Aneni E, Osondu C, Joseph J, Saeed G, Valero-Elizondo J, Veledar E, Nasir K. Habitual sleep duration and its relationship with cardiovascular health, healthcare costs, and resource utilization in a working population. Sleep Health 2022, 9: 77-85. PMID: 36371382, PMCID: PMC9991949, DOI: 10.1016/j.sleh.2022.10.001.Peer-Reviewed Original ResearchConceptsCardiovascular healthHabitual sleep durationSleep durationHealthcare expendituresHealthcare costsOptimal cardiovascular healthIdeal cardiovascular healthBaptist Health South FloridaHealthcare resource utilizationBody mass indexBetter cardiovascular healthMedical claims dataHours of sleepLower healthcare expendituresCVH metricsMore hoursBlood pressureMass indexMean ageEmergency roomCardiovascular diseaseHigher oddsHispanic ethnicityPhysical activityClaims dataLipoprotein Sub-Fractions by Ion-Mobility Analysis and Its Association with Subclinical Coronary Atherosclerosis in High-Risk Individuals
Aneni EC, Osondu CU, De La Cruz J, Martin SS, Blaha MJ, Younus A, Feldman T, Agatston AS, Veledar E, Nasir K. Lipoprotein Sub-Fractions by Ion-Mobility Analysis and Its Association with Subclinical Coronary Atherosclerosis in High-Risk Individuals. Journal Of Atherosclerosis And Thrombosis 2018, 26: 50-63. PMID: 30224606, PMCID: PMC6308270, DOI: 10.5551/jat.40741.Peer-Reviewed Original ResearchConceptsCoronary artery calcificationLipoprotein subfractionsCoronary atherosclerosisRisk of CACLipoprotein particlesLipoprotein subfraction analysisSubclinical coronary atherosclerosisBaptist Health South FloridaLarge LDL particlesHigh-risk personsHigh-risk populationHigh-risk individualsTriglyceride-rich lipoproteinsHigh-risk workersArtery calcificationIDL particlesMetabolic syndromeLipoprotein profileHDL lipoproteinsMean ageLipoprotein subclassesMedium LDLStudy populationRisk individualsVLDL particlesThe relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis
Osondu CU, Vo B, Oni ET, Blaha MJ, Veledar E, Feldman T, Agatston AS, Nasir K, Aneni EC. The relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis. Vascular Medicine 2017, 23: 9-20. PMID: 29243995, DOI: 10.1177/1358863x17725809.Peer-Reviewed Original ResearchConceptsCarotid intima-media thicknessAssociation of EDFlow-mediated dilationSubclinical cardiovascular diseaseCoronary artery calcificationErectile dysfunctionCardiovascular diseaseHigher carotid intima-media thicknessAnkle-brachial indexToe-brachial indexCVD risk assessmentIntima-media thicknessPulse wave velocityArtery calcificationEndothelial dysfunctionCVD mortalityMean ageVascular functionStudy qualityStudy populationAssessment QuestionnaireSystematic reviewDysfunctionPercentage point reductionMultiple databasesEstimates of Mortality Benefit From Ideal Cardiovascular Health Metrics: A Dose Response Meta‐Analysis
Aneni EC, Crippa A, Osondu CU, Valero‐Elizondo J, Younus A, Nasir K, Veledar E. Estimates of Mortality Benefit From Ideal Cardiovascular Health Metrics: A Dose Response Meta‐Analysis. Journal Of The American Heart Association 2017, 6: e006904. PMID: 29269350, PMCID: PMC5779012, DOI: 10.1161/jaha.117.006904.Peer-Reviewed Original ResearchConceptsIdeal cardiovascular healthIdeal CVH metricsPooled hazard ratioCVH metricsCardiovascular healthMortality benefitHazard ratioCardiovascular disease-related mortalityDose–response meta analysisStrong public health messageIdeal cardiovascular health metricsSubstantial mortality benefitCardiovascular health metricsCardiovascular disease mortalityLinear dose-response relationshipDisease-related mortalityPublic health messagesHazard ratio estimatesDose-response relationshipUnit increaseWeb of ScienceCause mortalityInternet literature searchDisease mortalityCardiovascular diseaseA Systematic Review of Internet-Based Worksite Wellness Approaches for Cardiovascular Disease Risk Management: Outcomes, Challenges & Opportunities
Aneni EC, Roberson LL, Maziak W, Agatston AS, Feldman T, Rouseff M, Tran TH, Blumenthal RS, Blaha MJ, Blankstein R, Al-Mallah MH, Budoff MJ, Nasir K. A Systematic Review of Internet-Based Worksite Wellness Approaches for Cardiovascular Disease Risk Management: Outcomes, Challenges & Opportunities. PLOS ONE 2014, 9: e83594. PMID: 24421894, PMCID: PMC3885454, DOI: 10.1371/journal.pone.0083594.Peer-Reviewed Original ResearchConceptsInternet-based programCardiovascular wellnessSystematic reviewCardiovascular disease risk managementCardiovascular health outcomesInclusion/exclusion criteriaPhysical activity outcomesSpecific disease entityWeb of ScienceCV healthRandomized trialsCochrane LibraryBlood glucoseDisease entityDisease risk managementPhysical activityExclusion criteriaRisk populationsHealth outcomesWellness interventionsPrevention programsActivity outcomesIntervention typeWellness approachBlue-collar workersThe Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve
Aneni E, Thorn S, Feher A, Hong Chen J, Sinusas A, Yaggi H, Miller E. The Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve. JACC Cardiovascular Imaging 2023, 16: 856-858. PMID: 36881426, PMCID: PMC10718199, DOI: 10.1016/j.jcmg.2022.11.024.Peer-Reviewed Original ResearchBlood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk
Aneni EC, Oni ET, Martin SS, Blaha MJ, Agatston AS, Feldman T, Veledar E, Conçeicao RD, Carvalho JA, Santos RD, Nasir K. Blood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk. Journal Of Hypertension 2015, 33: 1207-1214. PMID: 25693058, DOI: 10.1097/hjh.0000000000000532.Peer-Reviewed Original ResearchConceptsNonobese hypertensive patientsPrevalence of NAFLDMetabolic risk factorsHypertensive patientsNormal BPRisk factorsHigh Blood Pressure classificationNonalcoholic fatty liver diseaseHealthy middle-aged menBlood pressure groupJoint National CommitteeDevelopment of hypertensionFatty liver diseaseYearly physical examinationMiddle-aged menBlood pressure classificationBP controlPrehypertensive patientsCardiometabolic riskCross-sectional relationshipBlood pressureNAFLD severityLiver diseaseNormotensive individualsPhysical examination
2024
Trends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York
Anuforo A, Aneni E, Akintoye E, Anikpezie N, Patel S, Soipe A, Olojakpoke E, Burke D, Latorre J, Khandelwal P, Chaturvedi S, Ovbiagele B, Otite F. Trends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York. Circulation 2024, 149: 1391-1393. PMID: 38648273, DOI: 10.1161/circulationaha.123.066921.Peer-Reviewed Original Research
2023
Demographic Disparities in the Incidence, Clinical Characteristics, and Outcome of Posterior Reversible Encephalopathy Syndrome in the United States
Otite F, Patel S, Anikpezie N, Hoffman H, Beutler T, Akano E, Aneni E, Lamikanra O, Osondu C, Wee C, Burke D, Albright K, Latorre J, Mejico L, Khandelwal P, Chaturvedi S. Demographic Disparities in the Incidence, Clinical Characteristics, and Outcome of Posterior Reversible Encephalopathy Syndrome in the United States. Neurology 2023, 101: e1554-e1559. PMID: 37487751, PMCID: PMC10585693, DOI: 10.1212/wnl.0000000000207604.Peer-Reviewed Original ResearchConceptsPosterior reversible encephalopathy syndromeNational Readmission DatabaseReversible encephalopathy syndromeEncephalopathy syndromeFemale patientsHispanic patientsMale patientsSex-standardized incidenceRetrospective cohort studyRace-specific incidenceSimilar demographic distributionState Inpatient DatabasesNon-Hispanic whitesIncident hospitalizationClinical characteristicsCohort studyFirst hospitalizationBlack patientsInpatient DatabasePatientsNew casesIncidenceStudy periodDemographic disparitiesHospitalizationAge- and Sex-Specific Trends in Medical Complications After Acute Ischemic Stroke in the United States
Ahmed R, Mhina C, Philip K, Patel S, Aneni E, Osondu C, Lamikanra O, Akano E, Anikpezie N, Albright K, Latorre J, Chaturvedi S, Otite F. Age- and Sex-Specific Trends in Medical Complications After Acute Ischemic Stroke in the United States. Neurology 2023, 100: e1282-e1295. PMID: 36599695, PMCID: PMC10033158, DOI: 10.1212/wnl.0000000000206749.Peer-Reviewed Original ResearchConceptsSex-specific prevalenceAIS admissionsNoninfectious complicationsAcute ischemic stroke hospitalizationsSerial cross-sectional studyPrevalence of UTIRisk of UTIAcute ischemic strokeNational Inpatient SampleNIH Stroke ScaleIschemic stroke hospitalizationsCross-sectional studyAge/sexSex-specific trendsHospital mortalityInfectious complicationsMultivariable adjustmentStroke ScaleCommon complicationIschemic strokeMechanical thrombectomyMedical complicationsComplication riskPE prevalenceStroke hospitalizations
2022
Trends in age and sex-specific prevalence of cancer and cancer subtypes in acute ischemic stroke from 2007-2019
Otite F, Somani S, Aneni E, Akano E, Patel S, Anikpezie N, Lamikanra O, Masoud H, Latorre J, Chaturvedi S, Mehndiratta P. Trends in age and sex-specific prevalence of cancer and cancer subtypes in acute ischemic stroke from 2007-2019. Journal Of Stroke And Cerebrovascular Diseases 2022, 31: 106818. PMID: 36323171, DOI: 10.1016/j.jstrokecerebrovasdis.2022.106818.Peer-Reviewed Original ResearchConceptsSex-specific prevalenceCancer prevalenceGenitourinary cancersAIS admissionsActive cancerGastrointestinal cancerMetastatic cancerSolid cancersPrimary central nervous system cancerRetrospective serial cross-sectional studyAcute ischemic stroke hospitalizationsSerial cross-sectional studyCentral nervous system cancerLung cancer prevalenceAcute ischemic strokeNational Inpatient SampleIschemic stroke hospitalizationsHead/neckNervous system cancersCommon solid cancersCross-sectional studyPrevalence of cancerCancer admissionsIschemic strokeStroke hospitalizationsCardiometabolic disorders, inflammation and the incidence of non-alcoholic fatty liver disease: A longitudinal study comparing lean and non-lean individuals
Aneni E, Saeed G, Bittencourt M, Cainzos-Achirica M, Osondu C, Budoff M, Parise E, Santos R, Nasir K. Cardiometabolic disorders, inflammation and the incidence of non-alcoholic fatty liver disease: A longitudinal study comparing lean and non-lean individuals. PLOS ONE 2022, 17: e0266505. PMID: 35385529, PMCID: PMC8985996, DOI: 10.1371/journal.pone.0266505.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseRisk of NAFLDElevated blood glucoseElevated blood pressureFatty liver diseaseBlood glucoseLean individualsBlood pressureCardiometabolic disordersPhysical inactivityWaist circumferenceLiver diseaseDevelopment of NAFLDHigh-sensitivity C-reactive proteinCardiovascular disease risk stratificationSensitivity C-reactive proteinCardiometabolic risk factorsAlcohol Use Disorders Identification TestC-reactive proteinMain exposure variableDisease risk stratificationHospital Israelita Albert EinsteinDisorders Identification TestAppropriate preventive measuresAtherogenic dyslipidemia
2021
Quantifying radiotracer activity on cardiac sympathetic imaging: Does it really matter?
Aneni EC, Sinusas AJ. Quantifying radiotracer activity on cardiac sympathetic imaging: Does it really matter? Journal Of Nuclear Cardiology 2021, 29: 426-429. PMID: 34341954, DOI: 10.1007/s12350-021-02738-z.Commentaries, Editorials and Letters
2019
Gaps in provider lifestyle counseling and its adherence among obese adults with prediabetes and diabetes in the United States
Valero-Elizondo J, Aneni EC, Osondu CU, Grandhi GR, Virani SS, Nasir K. Gaps in provider lifestyle counseling and its adherence among obese adults with prediabetes and diabetes in the United States. Preventive Medicine 2019, 129: 105815. PMID: 31454663, DOI: 10.1016/j.ypmed.2019.105815.Peer-Reviewed Original ResearchConceptsLifestyle counselingObese adultsHealthcare providersManagement of obesityPrevalence of diabetesWeight loss programUS adult populationLevels of obesityLifestyle modificationDiabetes statusObese patientsSevere obesityLoss programMild obesityCardiovascular diseasePhysical activityObesity epidemicObesityDiabetesMetabolic diseasesAdult populationHealthy lifestyleCounselingPatientsAdults
2016
Chronic Toxic Metal Exposure and Cardiovascular Disease: Mechanisms of Risk and Emerging Role of Chelation Therapy
Aneni EC, Escolar E, Lamas GA. Chronic Toxic Metal Exposure and Cardiovascular Disease: Mechanisms of Risk and Emerging Role of Chelation Therapy. Current Atherosclerosis Reports 2016, 18: 81. PMID: 27822681, DOI: 10.1007/s11883-016-0631-0.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseSecondary preventionToxic metal exposureChelation therapyCardiovascular disease-related morbidityDisease-related morbidityAtherosclerotic cardiovascular diseaseMulticenter trialEpidemiologic evidenceMetal exposureChronic exposurePositive findingsMechanisms of riskDiseaseEmerging RoleRecent evidenceTherapyExposurePreventionMetal chelation therapyMorbidityMortalityFindingsTrialsA Systematic Review of the Prevalence and Outcomes of Ideal Cardiovascular Health in US and Non-US Populations
Younus A, Aneni EC, Spatz ES, Osondu CU, Roberson L, Ogunmoroti O, Malik R, Ali SS, Aziz M, Feldman T, Virani SS, Maziak W, Agatston AS, Veledar E, Nasir K. A Systematic Review of the Prevalence and Outcomes of Ideal Cardiovascular Health in US and Non-US Populations. Mayo Clinic Proceedings 2016, 91: 649-670. PMID: 27040086, DOI: 10.1016/j.mayocp.2016.01.019.Peer-Reviewed Original ResearchConceptsIdeal CVH metricsNon-CVD outcomesIdeal cardiovascular health metricsCVH metricsIdeal cardiovascular healthCardiovascular healthLow prevalenceAmerican Heart Association ideal cardiovascular health (CVH) metricsSystematic reviewMore ideal CVH metricsIncident cardiovascular eventsCardiovascular health metricsPopulation-based studyNon-US populationsCochrane RegisterCardiovascular eventsControlled TrialsUS cohortInverse associationCardiovascular diseaseCINAHL databasesMortality riskMortality studyCognitive impairmentUS population
2015
Prevalence of Ideal Cardiovascular Health Among Adults in the United States
Younus A, Aneni EC, Spatz ES, Osondu CU, Shaharyar S, Roberson L, Ali SS, Ogunmoroti O, Ahmad R, Post J, Feldman T, Maziak W, Agatston AS, Veledar E, Nasir K. Prevalence of Ideal Cardiovascular Health Among Adults in the United States. Journal Of The American College Of Cardiology 2015, 66: 1633-1634. PMID: 26429090, DOI: 10.1016/j.jacc.2015.06.1348.Peer-Reviewed Original ResearchObesity Modifies the Effect of Fitness on Heart Rate Indices during Exercise Stress Testing in Asymptomatic Individuals
Aneni EC, Oni ET, Osondu CU, Martin SS, Blaha MJ, Veledar E, Agatston AS, Feldman T, Carvalho JA, Conceição RD, Santos RD, Nasir K. Obesity Modifies the Effect of Fitness on Heart Rate Indices during Exercise Stress Testing in Asymptomatic Individuals. Cardiology 2015, 132: 242-248. PMID: 26329389, DOI: 10.1159/000435907.Peer-Reviewed Original ResearchConceptsHeart rateHR recoveryDifferent body mass index (BMI) categoriesBody mass index categoriesExercise stress testExercise stress testingExercise heart ratePeak heart rateHeart rate indexCross-sectional analysisEffects of fitnessObesity modifiesAsymptomatic cohortPeak exerciseBMI categoriesObese subjectsAsymptomatic individualsMetabolic equivalentsIndex categoriesMultivariate analysisAerobic fitnessBrazilian subjectsWeight lossStatistical significanceStress testingElevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging
Malik R, Aneni EC, Shahrayar S, Freitas WM, Ali SS, Veledar E, Latif MA, Aziz M, Ahmed R, Khan SA, Joseph J, Feiz H, Sposito A, Nasir K. Elevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging. Aging Clinical And Experimental Research 2015, 28: 359-362. PMID: 26084248, DOI: 10.1007/s40520-015-0395-3.Peer-Reviewed Original ResearchConceptsSerum uric acidElevated hs-CRPCoronary artery calcificationHs-CRPSUA tertilesCardiovascular diseaseCoronary atherosclerosisHealthy octogenariansArtery calcificationVascular inflammationAssociation of SUATertiles of SUAElevated serum uric acidSensitive C-reactive proteinMedian hs-CRPClinical cardiovascular diseaseHigher SUA levelsC-reactive proteinSubclinical cardiovascular diseaseUric acidCAC burdenCAC presenceSUA levelsOverall prevalenceElderly population
2014
Measuring coronary artery calcification: Is serum vitamin D relevant?
Malik R, Aneni EC, Roberson L, Ogunmoroti O, Ali SS, Shaharyar S, Younus A, Jamal O, Aziz MA, Martin SS, Blaha MJ, Feldman T, Agatston AS, Veledar E, Nasir K. Measuring coronary artery calcification: Is serum vitamin D relevant? Atherosclerosis 2014, 237: 734-738. PMID: 25463113, DOI: 10.1016/j.atherosclerosis.2014.10.087.Peer-Reviewed Original ResearchConceptsCoronary artery calciumLow vitamin D levelsSubclinical coronary atherosclerosisVitamin D levelsCoronary atherosclerosisVitamin DD levelsFurther high-quality studiesVitamin D relevantLow vitamin DCoronary artery calcificationSystematic MEDLINE searchHigh-quality studiesCAC incidenceCAC progressionArtery calcificationArtery calciumCAC prevalenceCAC severityInclusion criteriaMEDLINE searchInsufficient evidenceConsistent associationSmall sample sizeOnly study