Featured Publications
Habitual sleep duration and its relationship with cardiovascular health, healthcare costs, and resource utilization in a working population
Aneni E, Osondu C, Joseph J, Saeed G, Valero-Elizondo J, Veledar E, Nasir K. Habitual sleep duration and its relationship with cardiovascular health, healthcare costs, and resource utilization in a working population. Sleep Health 2022, 9: 77-85. PMID: 36371382, PMCID: PMC9991949, DOI: 10.1016/j.sleh.2022.10.001.Peer-Reviewed Original ResearchConceptsCardiovascular healthHabitual sleep durationSleep durationHealthcare expendituresHealthcare costsOptimal cardiovascular healthIdeal cardiovascular healthBaptist Health South FloridaHealthcare resource utilizationBody mass indexBetter cardiovascular healthMedical claims dataHours of sleepLower healthcare expendituresCVH metricsMore hoursBlood pressureMass indexMean ageEmergency roomCardiovascular diseaseHigher oddsHispanic ethnicityPhysical activityClaims dataThe relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis
Osondu CU, Vo B, Oni ET, Blaha MJ, Veledar E, Feldman T, Agatston AS, Nasir K, Aneni EC. The relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis. Vascular Medicine 2017, 23: 9-20. PMID: 29243995, DOI: 10.1177/1358863x17725809.Peer-Reviewed Original ResearchConceptsCarotid intima-media thicknessAssociation of EDFlow-mediated dilationSubclinical cardiovascular diseaseCoronary artery calcificationErectile dysfunctionCardiovascular diseaseHigher carotid intima-media thicknessAnkle-brachial indexToe-brachial indexCVD risk assessmentIntima-media thicknessPulse wave velocityArtery calcificationEndothelial dysfunctionCVD mortalityMean ageVascular functionStudy qualityStudy populationAssessment QuestionnaireSystematic reviewDysfunctionPercentage point reductionMultiple databasesEstimates of Mortality Benefit From Ideal Cardiovascular Health Metrics: A Dose Response Meta‐Analysis
Aneni EC, Crippa A, Osondu CU, Valero‐Elizondo J, Younus A, Nasir K, Veledar E. Estimates of Mortality Benefit From Ideal Cardiovascular Health Metrics: A Dose Response Meta‐Analysis. Journal Of The American Heart Association 2017, 6: e006904. PMID: 29269350, PMCID: PMC5779012, DOI: 10.1161/jaha.117.006904.Peer-Reviewed Original ResearchConceptsIdeal cardiovascular healthIdeal CVH metricsPooled hazard ratioCVH metricsCardiovascular healthMortality benefitHazard ratioCardiovascular disease-related mortalityDose–response meta analysisStrong public health messageIdeal cardiovascular health metricsSubstantial mortality benefitCardiovascular health metricsCardiovascular disease mortalityLinear dose-response relationshipDisease-related mortalityPublic health messagesHazard ratio estimatesDose-response relationshipUnit increaseWeb of ScienceCause mortalityInternet literature searchDisease mortalityCardiovascular diseaseAtherosclerotic plaque in individuals without known cardiovascular disease but with established obstructive sleep apnea and at high risk of obstructive sleep apnea
Walia H, Khosla A, Saxena A, Aneni E, Ali S, Valero-Elizondo J, Cainzos-Achirica M, Feldman T, Fialkow J, Nasir K. Atherosclerotic plaque in individuals without known cardiovascular disease but with established obstructive sleep apnea and at high risk of obstructive sleep apnea. American Journal Of Preventive Cardiology 2023, 14: 100497. PMID: 37131984, PMCID: PMC10149201, DOI: 10.1016/j.ajpc.2023.100497.Peer-Reviewed Original ResearchObstructive sleep apneaCoronary plaquesHigh riskSleep apneaLower riskBerlin questionnaireRisk factorsCT angiographySignificant associationMultivariable logistic regression analysisCardiovascular risk factorsCVD risk factorsLarge U.S. cohortCoronary CT angiographyLogistic regression analysisPopulation-based sampleComposition of plaquesLogistic regression modelsOSA cohortOSA presenceCoronary atherosclerosisOSA severityOSA categoriesSubgroup analysisCardiovascular disease
2024
Association between high risk of obstructive sleep apnea and inflammatory markers in a population sample of young and middle-aged adults in the Miami Heart Study.
Khosla A, Nasir K, Saxena A, Aneni E, Ali S, Valero-Elizondo J, Cainzos-Achirica M, Feldman T, Fialkow J, Walia H. Association between high risk of obstructive sleep apnea and inflammatory markers in a population sample of young and middle-aged adults in the Miami Heart Study. Journal Of Clinical Sleep Medicine 2024 PMID: 38975989, DOI: 10.5664/jcsm.11274.Peer-Reviewed Original ResearchHigh risk of obstructive sleep apneaRisk of obstructive sleep apneaObstructive sleep apneaHs-CRPCardiovascular disease risk factorsFree of cardiovascular diseaseInflammatory markersHigh riskCardiovascular diseaseIL-6Sleep apneaLow risk of obstructive sleep apneaTNF-aObstructive sleep apnea screeningLow riskRisk factorsLevels of inflammatory markersLevels of hs-CRPTNF-a levelsCVD-free participantsHeart StudyBerlin questionnaireIndividuals free of cardiovascular diseaseSubclinical inflammationPoisson regression analysis
2020
Non-Alcoholic Fatty Liver Disease Modifies Serum Gamma-Glutamyl Transferase in Cigarette Smokers
Oni ET, Figueredo V, Aneni E, Veladar E, McEvoy JW, Blaha MJ, Blumenthal RS, Conceicao RD, Carvalho JAM, Santos RD, Nasir K. Non-Alcoholic Fatty Liver Disease Modifies Serum Gamma-Glutamyl Transferase in Cigarette Smokers. Journal Of Clinical Medicine Research 2020, 12: 472-482. PMID: 32849935, PMCID: PMC7430878, DOI: 10.14740/jocmr3932.Peer-Reviewed Original ResearchNon-alcoholic fatty liver diseaseGamma-glutamyl transferaseSerum gamma-glutamyl transferaseClinical cardiovascular diseaseHigh GGT levelsGGT levelsNAFLD statusOxidative stressAbsence of NAFLDPresence of NAFLDPrevalence of NAFLDFatty liver diseaseImpact of smokingCross-sectional associationsCV riskCardiovascular riskCurrent smokersCurrent smokingMultivariable adjustmentLiver diseaseCigarette smokersEffect modificationCardiovascular diseaseHealthy subjectsSmoking
2019
Gaps in provider lifestyle counseling and its adherence among obese adults with prediabetes and diabetes in the United States
Valero-Elizondo J, Aneni EC, Osondu CU, Grandhi GR, Virani SS, Nasir K. Gaps in provider lifestyle counseling and its adherence among obese adults with prediabetes and diabetes in the United States. Preventive Medicine 2019, 129: 105815. PMID: 31454663, DOI: 10.1016/j.ypmed.2019.105815.Peer-Reviewed Original ResearchConceptsLifestyle counselingObese adultsHealthcare providersManagement of obesityPrevalence of diabetesWeight loss programUS adult populationLevels of obesityLifestyle modificationDiabetes statusObese patientsSevere obesityLoss programMild obesityCardiovascular diseasePhysical activityObesity epidemicObesityDiabetesMetabolic diseasesAdult populationHealthy lifestyleCounselingPatientsAdults
2016
Chronic Toxic Metal Exposure and Cardiovascular Disease: Mechanisms of Risk and Emerging Role of Chelation Therapy
Aneni EC, Escolar E, Lamas GA. Chronic Toxic Metal Exposure and Cardiovascular Disease: Mechanisms of Risk and Emerging Role of Chelation Therapy. Current Atherosclerosis Reports 2016, 18: 81. PMID: 27822681, DOI: 10.1007/s11883-016-0631-0.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseSecondary preventionToxic metal exposureChelation therapyCardiovascular disease-related morbidityDisease-related morbidityAtherosclerotic cardiovascular diseaseMulticenter trialEpidemiologic evidenceMetal exposureChronic exposurePositive findingsMechanisms of riskDiseaseEmerging RoleRecent evidenceTherapyExposurePreventionMetal chelation therapyMorbidityMortalityFindingsTrialsA Systematic Review of the Prevalence and Outcomes of Ideal Cardiovascular Health in US and Non-US Populations
Younus A, Aneni EC, Spatz ES, Osondu CU, Roberson L, Ogunmoroti O, Malik R, Ali SS, Aziz M, Feldman T, Virani SS, Maziak W, Agatston AS, Veledar E, Nasir K. A Systematic Review of the Prevalence and Outcomes of Ideal Cardiovascular Health in US and Non-US Populations. Mayo Clinic Proceedings 2016, 91: 649-670. PMID: 27040086, DOI: 10.1016/j.mayocp.2016.01.019.Peer-Reviewed Original ResearchConceptsIdeal CVH metricsNon-CVD outcomesIdeal cardiovascular health metricsCVH metricsIdeal cardiovascular healthCardiovascular healthLow prevalenceAmerican Heart Association ideal cardiovascular health (CVH) metricsSystematic reviewMore ideal CVH metricsIncident cardiovascular eventsCardiovascular health metricsPopulation-based studyNon-US populationsCochrane RegisterCardiovascular eventsControlled TrialsUS cohortInverse associationCardiovascular diseaseCINAHL databasesMortality riskMortality studyCognitive impairmentUS population
2015
Elevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging
Malik R, Aneni EC, Shahrayar S, Freitas WM, Ali SS, Veledar E, Latif MA, Aziz M, Ahmed R, Khan SA, Joseph J, Feiz H, Sposito A, Nasir K. Elevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging. Aging Clinical And Experimental Research 2015, 28: 359-362. PMID: 26084248, DOI: 10.1007/s40520-015-0395-3.Peer-Reviewed Original ResearchConceptsSerum uric acidElevated hs-CRPCoronary artery calcificationHs-CRPSUA tertilesCardiovascular diseaseCoronary atherosclerosisHealthy octogenariansArtery calcificationVascular inflammationAssociation of SUATertiles of SUAElevated serum uric acidSensitive C-reactive proteinMedian hs-CRPClinical cardiovascular diseaseHigher SUA levelsC-reactive proteinSubclinical cardiovascular diseaseUric acidCAC burdenCAC presenceSUA levelsOverall prevalenceElderly population
2014
Beyond BMI: The “Metabolically healthy obese” phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review
Roberson LL, Aneni EC, Maziak W, Agatston A, Feldman T, Rouseff M, Tran T, Blaha MJ, Santos RD, Sposito A, Al-Mallah MH, Blankstein R, Budoff MJ, Nasir K. Beyond BMI: The “Metabolically healthy obese” phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review. BMC Public Health 2014, 14: 14. PMID: 24400816, PMCID: PMC3890499, DOI: 10.1186/1471-2458-14-14.Peer-Reviewed Original ResearchConceptsIncident cardiovascular diseaseCoronary artery calciumSubclinical cardiovascular diseaseCause mortalityCardiovascular diseaseCVD mortalityCommon carotid artery intima-media thicknessAdult Treatment Panel III definitionCarotid artery intima-media thicknessArtery intima-media thicknessDefinition of MHOHealthy obese populationSubclinical CVD markersTypical metabolic disordersMetabolic syndrome componentsIntima-media thicknessRisk cardiovascular diseaseWeb of ScienceCVD markersHealthy obeseMHO groupArtery calciumCVD riskSyndrome componentsMetabolic syndrome