2024
Changes in Frontoamygdala Circuitry Associated With a Parent-Focused Intervention for Pediatric Anxiety Disorders
Gee D, Gunther K, Petrie D, Kitt E, Keding T, Broussard A, Zacharek S, Nardini C, Hommel G, Martino A, Anderson T, Spencer H, Odriozola P, Marin C, Silverman W, Lebowitz E. Changes in Frontoamygdala Circuitry Associated With a Parent-Focused Intervention for Pediatric Anxiety Disorders. Biological Psychiatry 2024, 95: s44. DOI: 10.1016/j.biopsych.2024.02.110.Peer-Reviewed Original Research
2018
Atypical frontoamygdala functional connectivity in youth with autism
Odriozola P, Dajani DR, Burrows CA, Gabard-Durnam LJ, Goodman E, Baez AC, Tottenham N, Uddin LQ, Gee DG. Atypical frontoamygdala functional connectivity in youth with autism. Developmental Cognitive Neuroscience 2018, 37: 100603. PMID: 30581125, PMCID: PMC6570504, DOI: 10.1016/j.dcn.2018.12.001.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderRostral anterior cingulate cortexFunctional connectivityTD individualsDifferent age-related patternsResting-state functional connectivityOverall group differencesBroad developmental rangeAnterior cingulate cortexSocioemotional functioningSocioemotional impairmentsSpectrum disorderCross-sectional sampleAge-related changesRight basolateral amygdalaCingulate cortexAge-related patternsGroup differencesDevelopmental rangeFrontoamygdala circuitryBasolateral amygdalaAmygdalaIndividualsPrior workImpairment
2016
Sensitive Periods of Emotion Regulation: Influences of Parental Care on Frontoamygdala Circuitry and Plasticity
Gee DG. Sensitive Periods of Emotion Regulation: Influences of Parental Care on Frontoamygdala Circuitry and Plasticity. New Directions For Child And Adolescent Development 2016, 2016: 87-110. PMID: 27589500, DOI: 10.1002/cad.20166.Peer-Reviewed Original ResearchIndividual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species
Gee DG, Fetcho RN, Jing D, Li A, Glatt CE, Drysdale AT, Cohen AO, Dellarco DV, Yang RR, Dale AM, Jernigan TL, Lee FS, Casey BJ, Jernigan T, San Diego U, McCabe C, San Diego U, Chang L, Hawaii U, Akshoomoff N, San Diego U, Newman E, San Diego U, Dale A, San Diego U, Core M, Ernst T, Hawaii U, Dale A, San Diego U, Van Zijl P, Kuperman J, San Diego U, Murray S, Bloss C, Schork N, Appelbaum M, San Diego U, Gamst A, San Diego U, Thompson W, San Diego U, Bartsch H, San Diego U, Jernigan T, Dale A, Akshoomoff N, Chang L, Ernst T, Keating B, Amaral D, Sowell E, Kaufmann W, Van Zijl P, Mostofsky S, Casey B, Ruberry E, Powers A, Rosen B, Kenet T, Frazier J, Kennedy D, University Y, Gruen J. Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 4500-4505. PMID: 27001846, PMCID: PMC4843434, DOI: 10.1073/pnas.1600013113.Peer-Reviewed Original ResearchConceptsFatty acid amide hydrolaseAnxiety-related behaviorGene expressionFrontolimbic circuitryEndocannabinoid signalingAnxiety disordersNeural circuit maturationPostnatal day 45Phenotypic differencesFrontoamygdala circuitryAnandamide levelsGenetic effectsAEA levelsBiological stateIndividual differencesCircuit maturationGenetic alterationsFAAH genotypeMouse modelDevelopmental neurobiologyLevels of analysisAdolescent changesDevelopmental windowAmide hydrolaseBrain circuitry
2013
A Developmental Shift from Positive to Negative Connectivity in Human Amygdala–Prefrontal Circuitry
Gee DG, Humphreys KL, Flannery J, Goff B, Telzer EH, Shapiro M, Hare TA, Bookheimer SY, Tottenham N. A Developmental Shift from Positive to Negative Connectivity in Human Amygdala–Prefrontal Circuitry. Journal Of Neuroscience 2013, 33: 4584-4593. PMID: 23467374, PMCID: PMC3670947, DOI: 10.1523/jneurosci.3446-12.2013.Peer-Reviewed Original ResearchConceptsAmygdala-prefrontal circuitryFunctional connectivityNegative connectivityAmygdala reactivityRecent human imagingParticipants 10 yearsTask-based functional magnetic resonance imagingNegative functional connectivityFunctional magnetic resonance imagingMagnetic resonance imagingAmygdala-prefrontal connectivityAmygdala-cortical connectivityAnxiety-related disordersFrontoamygdala circuitryAnimal studiesReciprocal connectionsResonance imagingTracing studyPositive connectivityAdolescent periodEarly childhoodNeurobiological basisEmotional behaviorPresent studyDevelopmental changes