Sex modulates the ApoE ε4 effect on brain tau deposition measured by 18F-AV-1451 PET in individuals with mild cognitive impairment
Liu M, Paranjpe MD, Zhou X, Duy PQ, Goyal MS, Benzinger TLS, Lu J, Wang R, Zhou Y. Sex modulates the ApoE ε4 effect on brain tau deposition measured by 18F-AV-1451 PET in individuals with mild cognitive impairment. Theranostics 2019, 9: 4959-4970. PMID: 31410194, PMCID: PMC6691387, DOI: 10.7150/thno.35366.Peer-Reviewed Original ResearchConceptsBrain tau depositionMild cognitive impairmentAPOE ε4 carrier statusΕ4 carrier statusAPOE ε4Tau depositionCSF tauF-AVP-tauT-tauCognitive impairmentAlzheimer's diseaseSex interaction effectsApolipoprotein E type 4 alleleCerebrospinal fluid (CSF) total tauStrongest genetic risk factorMagnetic resonance imaging (MRI) scansCarrier statusPET spatial normalizationStandardized uptake value ratio (SUVR) imagesCSF p-tauCSF t-tauStructural magnetic resonance imaging (MRI) scansResonance imaging scansType 4 allele