2019
Lower synaptic density is associated with depression severity and network alterations
Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultDepressionDepressive Disorder, MajorFemaleHumansMaleMembrane GlycoproteinsMiddle AgedNerve Tissue ProteinsPositron-Emission TomographyStress Disorders, Post-TraumaticSynapsesConceptsMajor depressive disorderPost-traumatic stress disorderLower synaptic densitySynaptic densityPositron emission tomographyFunctional connectivityNetwork alterationsSynaptic vesicle glycoprotein 2ASymptoms of depressionSynaptic lossDepressive disorderHealthy controlsNerve terminalsDepressive symptomsDepression severityUnmedicated individualsSynaptic connectionsEmission tomographyStress disorderVivo evidenceSymptomsDepressionSeverityDisordersAlterations
2012
CT‐PET weighted image fusion for separately scanned whole body rat
Suh JW, Kwon O, Scheinost D, Sinusas AJ, Cline GW, Papademetris X. CT‐PET weighted image fusion for separately scanned whole body rat. Medical Physics 2012, 39: 533-542. PMID: 22225323, PMCID: PMC3266828, DOI: 10.1118/1.3672167.Peer-Reviewed Original ResearchConceptsEmission PET imagesInput imageRegistration processMultimodal registrationRegistration methodMultiple input imagesImage fusion applicationsImage fusion techniqueDistance similarity measureNormalized mutual informationComplementary anatomic informationDeformable registration processCT imagesSeparate scannersInformative imagesPET imagesImage fusionSimilarity measureFusion techniqueHistogram matchingImage setsPositron emission tomography (PET) imagesImage characteristicsNonrigid changesMutual information