2023
Assessing a multivariate model of brain-mediated genetic influences on disordered eating in the ABCD cohort
Westwater M, Mallard T, Warrier V, Bethlehem R, Scheinost D, Grillon C, Fletcher P, Seidlitz J, Ernst M. Assessing a multivariate model of brain-mediated genetic influences on disordered eating in the ABCD cohort. Nature Mental Health 2023, 1: 573-585. DOI: 10.1038/s44220-023-00101-4.Peer-Reviewed Original ResearchNeurobiological factorsPsychopathology symptomsFactor scoresCanonical brain networksThree-factor structureStructural equation modelingCritical developmental periodGray matter volumeCortical thicknessGreater genetic riskDisorder symptomatologyABCD studyEarly adolescenceDefault modeBrain networksAnxiety disordersGenetic riskIntervention effortsABCD cohortEquation modelingSubcortical gray matter volumesPsychopathology factorDevelopmental periodFear factorBrain structures
2021
Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth
Scheinost D, Dadashkarimi J, Finn ES, Wambach CG, MacGillivray C, Roule AL, Niendam TA, Pine DS, Brotman MA, Leibenluft E, Tseng WL. Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth. Neuropsychopharmacology 2021, 46: 1300-1306. PMID: 33479511, PMCID: PMC8134471, DOI: 10.1038/s41386-020-00954-8.Peer-Reviewed Original ResearchConceptsFunctional connectivityAttention-deficit/hyperactivity disorderCognitive flexibility taskDisruptive mood dysregulation disorderAffective Reactivity IndexLevels of irritabilityPreliminary fMRI studyCognitive flexibilityFlexibility taskIndividual differencesTransdiagnostic sampleFrontal networkFMRI studyHyperactivity disorderTask difficultyNeural mechanismsParent reportAnxiety symptomsSalience networkAnxiety disordersFrustrative nonrewardDimensional measuresPreliminary evidenceReactivity indexChild psychiatry