2007
Outer Surface Protein B Is Critical for Borrelia burgdorferi Adherence and Survival within Ixodes Ticks
Neelakanta G, Li X, Pal U, Liu X, Beck DS, DePonte K, Fish D, Kantor FS, Fikrig E. Outer Surface Protein B Is Critical for Borrelia burgdorferi Adherence and Survival within Ixodes Ticks. PLOS Pathogens 2007, 3: e33. PMID: 17352535, PMCID: PMC1817655, DOI: 10.1371/journal.ppat.0030033.Peer-Reviewed Original Research
2004
An ecological approach to preventing human infection: Vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle
Tsao J, Wootton J, Bunikis J, Luna M, Fish D, Barbour A. An ecological approach to preventing human infection: Vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 18159-18164. PMID: 15608069, PMCID: PMC536054, DOI: 10.1073/pnas.0405763102.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferiCommunicable DiseasesDisease ReservoirsEcologyGenotypeGlutathione TransferaseHumansImmunoenzyme TechniquesIxodesLipoproteinsLyme DiseaseMicePeromyscusPolymerase Chain ReactionRecombinant Fusion ProteinsTicksVaccinesConceptsWild white-footed miceTick infection prevalenceNegative control antigenReservoir host speciesVector-borne diseasesSympatric ticksField experimentDisease cycleB. burgdorferiDisease incidenceDisease agentsArthropod vectorsEcological approachAnimal reservoirsImmunization of humansMouse densityTicksHost speciesLyme disease agentInfection dynamicsHuman vaccinesPopulation structureWhite-footed miceOuter surface protein AHuman infections
2001
OspA Immunization Decreases Transmission of Borrelia burgdorferi Spirochetes from Infected Peromyscus leucopus Mice to Larval Ixodes scapularis Ticks
Tsao J, Barbour A, Luke C, Fikrig E, Fish D. OspA Immunization Decreases Transmission of Borrelia burgdorferi Spirochetes from Infected Peromyscus leucopus Mice to Larval Ixodes scapularis Ticks. Vector-Borne And Zoonotic Diseases 2001, 1: 65-74. PMID: 12653137, DOI: 10.1089/153036601750137705.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, WildAntibodies, BacterialAntigens, SurfaceArachnid VectorsBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferiDisease ReservoirsDose-Response Relationship, ImmunologicEnzyme-Linked Immunosorbent AssayFluorescent Antibody Technique, DirectHost-Parasite InteractionsIxodesLarvaLipoproteinsLyme DiseasePeromyscusConceptsControl miceUninfected larval ticksInfection prevalenceLarval Ixodes scapularis ticksB. burgdorferiNumber of spirochetesEnzyme-linked immunosorbentBorrelia burgdorferi spirochetesLevel of immunizationReservoir hostsConcentration of antibodyBorrelia burgdorferi transmissionIxodes scapularis ticksSecond vaccinationImmunized miceInfected miceLarval ticksPrior infectionVaccination programSubsequent riskDecrease transmissionOspA vaccinationDirect immunofluorescenceImmune responseXenodiagnostic ticksA Relapsing Fever Group Spirochete Transmitted by Ixodes scapularis Ticks
Scoles G, Papero M, Beati L, Fish D. A Relapsing Fever Group Spirochete Transmitted by Ixodes scapularis Ticks. Vector-Borne And Zoonotic Diseases 2001, 1: 21-34. PMID: 12653133, DOI: 10.1089/153036601750137624.Peer-Reviewed Original ResearchAnimalsAntigens, BacterialAntigens, SurfaceArachnid VectorsBacterial Outer Membrane ProteinsBacterial VaccinesBorreliaDNA, BacterialDNA, RibosomalFemaleFlagellinInfectious Disease Transmission, VerticalIxodesLipoproteinsPeromyscusPhylogenyPolymerase Chain ReactionRabbitsRelapsing FeverSequence Homology, Nucleic AcidSheep
2000
Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A
Pal U, de Silva A, Montgomery R, Fish D, Anguita J, Anderson J, Lobet Y, Fikrig E. Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A. Journal Of Clinical Investigation 2000, 106: 561-569. PMID: 10953031, PMCID: PMC380253, DOI: 10.1172/jci9427.Peer-Reviewed Original Research
1997
Detection of Borrelia burgdorferi OspA in Ixodes scapularis larvae by an antigen-capture enzyme-linked immunosorbent assay.
Mannelli A, Fish D, Daniels T, Kharitonenkov I, Tun H, Cozzolino A, Bucher D. Detection of Borrelia burgdorferi OspA in Ixodes scapularis larvae by an antigen-capture enzyme-linked immunosorbent assay. Microbiologica 1997, 20: 355-9. PMID: 9385607.Peer-Reviewed Original ResearchOspA antibodies inhibit the acquisition of Borrelia burgdorferi by Ixodes ticks
de Silva AM, Fish D, Burkot TR, Zhang Y, Fikrig E. OspA antibodies inhibit the acquisition of Borrelia burgdorferi by Ixodes ticks. Infection And Immunity 1997, 65: 3146-3150. PMID: 9234767, PMCID: PMC175444, DOI: 10.1128/iai.65.8.3146-3150.1997.Peer-Reviewed Original ResearchConceptsOspA antibodiesB. burgdorferiPassive antibody transferB. burgdorferi infectionIxodes ticksSurface protein ABurgdorferi-infected miceB. burgdorferi-infected miceLarval infection ratesOuter surface protein AAntibody transferAntibody responseBurgdorferi infectionInfection rateInfected ticksMiceInhibitory effectAntibodiesLarval infectionBorrelia burgdorferiBurgdorferiInfectionLarval ticksReservoir competenceSpirochetes
1995
Protection of Dogs from Lyme Disease with a Vaccine Containing Outer Surface Protein (Osp) A, OspB, and the Saponin Adjuvant QS21
Coughlin R, Fish D, Mather T, Ma J, Pavia C, Bulger P. Protection of Dogs from Lyme Disease with a Vaccine Containing Outer Surface Protein (Osp) A, OspB, and the Saponin Adjuvant QS21. The Journal Of Infectious Diseases 1995, 171: 1049-1052. PMID: 7706788, DOI: 10.1093/infdis/171.4.1049.Peer-Reviewed Original ResearchConceptsProtection of dogsAdjuvant QS21Vaccinated dogsControl dogsLyme diseaseIxodes scapularisOuter surface protein ABorrelia burgdorferi infectionB. burgdorferiSurface protein ADogsBurgdorferi infectionVaccineScapularisQS21InfectionDiseaseProtectionXenodiagnosisBurgdorferiProtein AFeverSymptomsLimp