2015
Association between body size and reservoir competence of mammals bearing Borrelia burgdorferi at an endemic site in the northeastern United States
Barbour AG, Bunikis J, Fish D, Hanincová K. Association between body size and reservoir competence of mammals bearing Borrelia burgdorferi at an endemic site in the northeastern United States. Parasites & Vectors 2015, 8: 299. PMID: 26024881, PMCID: PMC4459683, DOI: 10.1186/s13071-015-0903-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody SizeBorrelia burgdorferiDisease ReservoirsFemaleHumansIxodesLarvaLyme DiseaseMammalsNew EnglandNymphTick InfestationsConceptsBody sizeLarge-sized mammalsMedium-sized mammalsDifferent mammalian speciesEastern North AmericaSpecies-specific PCRLyme disease agentSmall mammalsMammalian speciesWhite-footed mouseCommon raccoonSized mammalsMammalsBorrelia burgdorferiPine volesBody massGrey squirrelsVirginia opossumReservoir competenceEastern chipmunksIxodes scapularis ticksDisease agentsStriped skunksSpeciesNymphal Ixodes scapularis ticksBorrelia miyamotoi infection in nature and in humans
Krause PJ, Fish D, Narasimhan S, Barbour AG. Borrelia miyamotoi infection in nature and in humans. Clinical Microbiology And Infection 2015, 21: 631-639. PMID: 25700888, PMCID: PMC4470780, DOI: 10.1016/j.cmi.2015.02.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsB. miyamotoi infectionMiyamotoi infectionClinical manifestationsB. miyamotoiLyme diseaseBorrelia miyamotoi infectionAcute febrile illnessCommon clinical manifestationsBlood smear examinationPublic health importanceHuman granulocytic anaplasmosisFever group spirochetesFebrile illnessAntibiotic therapyDisease groupEtiologic diagnosisSevere diseaseSmear examinationIxodes persulcatus ticksHealth importanceInfectionHuman casesGranulocytic anaplasmosisBorrelia miyamotoiDisease
2012
Predicted Outcomes of Vaccinating Wildlife to Reduce Human Risk of Lyme Disease
Tsao K, Fish D, Galvani AP. Predicted Outcomes of Vaccinating Wildlife to Reduce Human Risk of Lyme Disease. Vector-Borne And Zoonotic Diseases 2012, 12: 544-551. PMID: 22251312, DOI: 10.1089/vbz.2011.0731.Peer-Reviewed Original ResearchConceptsMice vaccinationTick biteB. burgdorferi transmissionLyme disease preventionTick blood mealVaccination outcomesHuman riskVaccination effortsDisease preventionLyme diseaseVaccinationInfection prevalenceBorrelia burgdorferiMiceWildlife vaccinationB. burgdorferiCausative agentPredicted outcomeBlood mealVector ticksBiteOutcomesBurgdorferiRiskWildlife reservoirs
2009
Niche Partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the Same Tick Vector and Mammalian Reservoir Species
Barbour A, Bunikis J, Travinsky B, Hoen A, Diuk-Wasser M, Fish D, Tsao J. Niche Partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the Same Tick Vector and Mammalian Reservoir Species. American Journal Of Tropical Medicine And Hygiene 2009, 81: 1120-1131. PMID: 19996447, PMCID: PMC2841027, DOI: 10.4269/ajtmh.2009.09-0208.Peer-Reviewed Original Research
2005
What about the ducks? An alternative vaccination strategy.
Fish D. What about the ducks? An alternative vaccination strategy. The Yale Journal Of Biology And Medicine 2005, 78: 301-8. PMID: 17132336, PMCID: PMC2259165.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease OutbreaksDisease ReservoirsDucksHumansInfluenza in BirdsInfluenza VaccinesInfluenza, HumanVaccination
2004
An ecological approach to preventing human infection: Vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle
Tsao J, Wootton J, Bunikis J, Luna M, Fish D, Barbour A. An ecological approach to preventing human infection: Vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 18159-18164. PMID: 15608069, PMCID: PMC536054, DOI: 10.1073/pnas.0405763102.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferiCommunicable DiseasesDisease ReservoirsEcologyGenotypeGlutathione TransferaseHumansImmunoenzyme TechniquesIxodesLipoproteinsLyme DiseaseMicePeromyscusPolymerase Chain ReactionRecombinant Fusion ProteinsTicksVaccinesConceptsWild white-footed miceTick infection prevalenceNegative control antigenReservoir host speciesVector-borne diseasesSympatric ticksField experimentDisease cycleB. burgdorferiDisease incidenceDisease agentsArthropod vectorsEcological approachAnimal reservoirsImmunization of humansMouse densityTicksHost speciesLyme disease agentInfection dynamicsHuman vaccinesPopulation structureWhite-footed miceOuter surface protein AHuman infectionsInteraction and Transmission of Two Borrelia burgdorferi Sensu Stricto Strains in a Tick-Rodent Maintenance System
Derdáková M, Dudiòák V, Brei B, Brownstein J, Schwartz I, Fish D. Interaction and Transmission of Two Borrelia burgdorferi Sensu Stricto Strains in a Tick-Rodent Maintenance System. Applied And Environmental Microbiology 2004, 70: 6783-6788. PMID: 15528545, PMCID: PMC525125, DOI: 10.1128/aem.70.11.6783-6788.2004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArachnid VectorsBorrelia burgdorferiDisease ReservoirsFemaleIxodesLyme DiseasePeromyscusRodent DiseasesTick InfestationsConceptsB. burgdorferi sensu strictoBurgdorferi sensu strictoXenodiagnostic ticksBorrelia burgdorferi sensu strictoUninfected larval ticksGroups of miceWhite-footed miceTransmission cycleControl miceInfected micePrimary infectionExperimental miceI. scapularis ticksLeucopus miceDouble infectionMiceLyme disease agentInfectionScapularis ticksMajor genotypesWeekly intervalsTransmission dynamicsExperimental groupSame strainLarval ticksBorrelia burgdorferi Infection in a Natural Population of Peromyscus Leucopus Mice: A Longitudinal Study in an Area Where Lyme Borreliosis Is Highly Endemic
Bunikis J, Tsao J, Luke C, Luna M, Fish D, Barbour A. Borrelia burgdorferi Infection in a Natural Population of Peromyscus Leucopus Mice: A Longitudinal Study in an Area Where Lyme Borreliosis Is Highly Endemic. The Journal Of Infectious Diseases 2004, 189: 1515-1523. PMID: 15073690, DOI: 10.1086/382594.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialAntigens, BacterialBacterial Outer Membrane ProteinsBlotting, WesternBorrelia burgdorferiConnecticutDisease ReservoirsDNA, BacterialEndemic DiseasesFemaleImmunoenzyme TechniquesIncidenceIxodesLongitudinal StudiesLyme DiseasePeromyscusPolymerase Chain ReactionRodent DiseasesSeasonsSeroepidemiologic StudiesConceptsPeromyscus leucopus miceLeucopus miceTransmission seasonBorrelia burgdorferi infectionPolymerase chain reactionSurface protein CBurgdorferi infectionBlood samplesMice ageEnzyme immunoassayLyme borreliosisMiceSerum samplesProtein CDynamics of infectionBorrelia burgdorferiB. burgdorferiChain reactionLongitudinal studyEnzootic siteInfectionAntibodiesEntire populationBurgdorferiIxodes scapularis
2002
Comparison of the Reservoir Competence of Medium-Sized Mammals and Peromyscus leucopus for Anaplasma phagocytophilum in Connecticut
Levin M, Nicholson W, Massung R, Sumner J, Fish D. Comparison of the Reservoir Competence of Medium-Sized Mammals and Peromyscus leucopus for Anaplasma phagocytophilum in Connecticut. Vector-Borne And Zoonotic Diseases 2002, 2: 125-136. PMID: 12737542, DOI: 10.1089/15303660260613693.Peer-Reviewed Original Research
2001
Interference Between the Agents of Lyme Disease and Human Granulocytic Ehrlichiosis in a Natural Reservoir Host
Levin M, Fish D. Interference Between the Agents of Lyme Disease and Human Granulocytic Ehrlichiosis in a Natural Reservoir Host. Vector-Borne And Zoonotic Diseases 2001, 1: 139-148. PMID: 12653144, DOI: 10.1089/153036601316977741.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisE. phagocytophilaB. burgdorferiGranulocytic ehrlichiosisLyme diseaseB. burgdorferi challengeGroups of miceB. burgdorferi-infected miceBurgdorferi-infected miceXenodiagnostic larvaeI. scapularis larvaeUninfected miceNatural reservoir hostsControl miceInfectious challengePrimary infectionXenodiagnostic ticksControl groupMiceInfectionMixed infectionsI. scapularis nymphsBurgdorferiWeekly intervalsSecond agentOspA Immunization Decreases Transmission of Borrelia burgdorferi Spirochetes from Infected Peromyscus leucopus Mice to Larval Ixodes scapularis Ticks
Tsao J, Barbour A, Luke C, Fikrig E, Fish D. OspA Immunization Decreases Transmission of Borrelia burgdorferi Spirochetes from Infected Peromyscus leucopus Mice to Larval Ixodes scapularis Ticks. Vector-Borne And Zoonotic Diseases 2001, 1: 65-74. PMID: 12653137, DOI: 10.1089/153036601750137705.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, WildAntibodies, BacterialAntigens, SurfaceArachnid VectorsBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferiDisease ReservoirsDose-Response Relationship, ImmunologicEnzyme-Linked Immunosorbent AssayFluorescent Antibody Technique, DirectHost-Parasite InteractionsIxodesLarvaLipoproteinsLyme DiseasePeromyscusConceptsControl miceUninfected larval ticksInfection prevalenceLarval Ixodes scapularis ticksB. burgdorferiNumber of spirochetesEnzyme-linked immunosorbentBorrelia burgdorferi spirochetesLevel of immunizationReservoir hostsConcentration of antibodyBorrelia burgdorferi transmissionIxodes scapularis ticksSecond vaccinationImmunized miceInfected miceLarval ticksPrior infectionVaccination programSubsequent riskDecrease transmissionOspA vaccinationDirect immunofluorescenceImmune responseXenodiagnostic ticks
2000
Immunity Reduces Reservoir Host Competence of Peromyscus leucopus forEhrlichia phagocytophila
Levin M, Fish D. Immunity Reduces Reservoir Host Competence of Peromyscus leucopus forEhrlichia phagocytophila. Infection And Immunity 2000, 68: 1514-1518. PMID: 10678968, PMCID: PMC97309, DOI: 10.1128/iai.68.3.1514-1518.2000.Peer-Reviewed Original ResearchConceptsE. phagocytophilaControl miceImmune responseNonimmune control miceWhite-footed miceSame agentsMajority of miceStrong immune responsePrevalence of infectionXenodiagnostic larvaeImmunized miceTick biteXenodiagnostic ticksIxodes scapularis nymphsControl groupSingle infectionEhrlichia phagocytophilaMiceUninfected ticksInfectionPartial protectionWeeksImmunityScapularis nymphsReservoir host competence
1994
Competence of dogs as reservoirs for Lyme disease spirochetes (Borrelia burgdorferi).
Mather T, Fish D, Coughlin R. Competence of dogs as reservoirs for Lyme disease spirochetes (Borrelia burgdorferi). Journal Of The American Veterinary Medical Association 1994, 205: 186-8. PMID: 7928571, DOI: 10.2460/javma.1994.205.02.186.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArachnid VectorsBorrelia burgdorferi GroupDisease ReservoirsDog DiseasesDogsFemaleLyme DiseaseMaleTicksConceptsDirect fluorescent antibodyBurgdorferi-infected ticksInfected adult ticksAdult deer ticksChallenge exposureImmature ticksInfected dogsLyme diseaseInfected ticksDogsBorrelia burgdorferiFluorescent antibodyDeer ticksBlood mealCompetent reservoirsAdult ticksHuman riskExposureLarval ticksReservoir competenceTicksDiseaseWeeksAntibodies
1993
The Biological and Social Phenomenon of Lyme Disease
Barbour A, Fish D. The Biological and Social Phenomenon of Lyme Disease. Science 1993, 260: 1610-1616. PMID: 8503006, DOI: 10.1126/science.8503006.Peer-Reviewed Original Research
1990
THE ROLE OF MEDIUM-SIZED MAMMALS AS RESERVOIRS OF BORRELIA BURGDORFERI IN SOUTHERN NEW YORK
Fish D, Daniels T. THE ROLE OF MEDIUM-SIZED MAMMALS AS RESERVOIRS OF BORRELIA BURGDORFERI IN SOUTHERN NEW YORK. Journal Of Wildlife Diseases 1990, 26: 339-345. PMID: 2388356, DOI: 10.7589/0090-3558-26.3.339.Peer-Reviewed Original Research
1989
Potential for exposure to tick bites in recreational parks in a Lyme disease endemic area.
Falco R, Fish D. Potential for exposure to tick bites in recreational parks in a Lyme disease endemic area. American Journal Of Public Health 1989, 79: 12-5. PMID: 2909174, PMCID: PMC1349459, DOI: 10.2105/ajph.79.1.12.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArachnid VectorsDisease ReservoirsHumansLyme DiseaseNew YorkRecreationSampling StudiesTicks
1988
PREVALENCE OF IXODES DAMMINI NEAR THE HOMES OF LYME DISEASE PATIENTS IN WESTCHESTER COUNTY, NEW YORK
FALCO R, FISH D. PREVALENCE OF IXODES DAMMINI NEAR THE HOMES OF LYME DISEASE PATIENTS IN WESTCHESTER COUNTY, NEW YORK. American Journal Of Epidemiology 1988, 127: 826-830. PMID: 3354547, DOI: 10.1093/oxfordjournals.aje.a114865.Peer-Reviewed Original Research