2007
Role of Outer Surface Protein D in the Borrelia burgdorferi Life Cycle
Li X, Neelakanta G, Liu X, Beck DS, Kantor FS, Fish D, Anderson JF, Fikrig E. Role of Outer Surface Protein D in the Borrelia burgdorferi Life Cycle. Infection And Immunity 2007, 75: 4237-4244. PMID: 17620358, PMCID: PMC1951184, DOI: 10.1128/iai.00632-07.Peer-Reviewed Original ResearchConceptsB. burgdorferiSecond blood mealMurine modelSpirochete transmissionB. burgdorferi persistenceLyme borreliosisMiceB. burgdorferi strainsProtein DI. scapularisTick gutBlood mealBurgdorferi strainsSpirochete life cycleBurgdorferiGut extractsIxodes scapularisB. burgdorferi infectivityThreefold decreaseHost-specific signalsScapularisTicksBorreliosis
2006
MyD88 Deficiency Enhances Acquisition and Transmission of Borrelia burgdorferi by Ixodes scapularis Ticks
Bockenstedt LK, Liu N, Schwartz I, Fish D. MyD88 Deficiency Enhances Acquisition and Transmission of Borrelia burgdorferi by Ixodes scapularis Ticks. Infection And Immunity 2006, 74: 2154-2160. PMID: 16552045, PMCID: PMC1418887, DOI: 10.1128/iai.74.4.2154-2160.2006.Peer-Reviewed Original ResearchConceptsMyD88-/- miceToll-like receptorsWT miceB. burgdorferiB. burgdorferi strainsInnate immune cellsBurgdorferi strainsSkin inoculation siteB. burgdorferi DNAHigh virulence strainDegree of infectivityIxodes scapularis ticksMyD88 deficiencyMolecule MyD88Immune cellsMore spirochetesTransmission of BorreliaEffector functionsHost immunityBorrelia burgdorferi strainsClinical isolatesPathogen burdenMiceBlood meal hostsScapularis ticks