2001
Flux control in the rat gastrocnemius glycogen synthesis pathway by in vivo13C/31P NMR spectroscopy
Chase J, Rothman D, Shulman R. Flux control in the rat gastrocnemius glycogen synthesis pathway by in vivo13C/31P NMR spectroscopy. AJP Endocrinology And Metabolism 2001, 280: e598-e607. PMID: 11254467, DOI: 10.1152/ajpendo.2001.280.4.e598.Peer-Reviewed Original ResearchConceptsGlycogen synthesisGlycogen synthesis pathwayInsulin-stimulated muscle glycogen synthesisMetabolic control analysisMuscle glycogen synthesisGlycogen synthaseSynthesis pathwayGlycogen synthesis rateFlux controlGSaseHyperglycemic glucose concentrationsSynthesis rateControl coefficientsHexokinaseRat gastrocnemius muscleRelative contributionNMR spectroscopyGlycolysisSynthasePathway
1995
In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis.
Shulman R, Bloch G, Rothman D. In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 8535-8542. PMID: 7567971, PMCID: PMC41002, DOI: 10.1073/pnas.92.19.8535.Peer-Reviewed Original ResearchConceptsCovalent phosphorylationGlycogen synthesisGlycogen synthaseMuscle glycogen synthaseVivo NMR methodsPositive allosteric effectorMetabolic control theoryAllosteric effectorsVivo regulationGSaseVivo NMR experimentsNMR experimentsPhosphorylationSynthesis fluxProximal stepMuscle glycogen synthesisSynthaseVivo NMRRegulationNMR methodsMetabolite levelsHuman muscleRat muscleEffectorsEnzyme
1991
13C-NMR measurements of muscle glycogen during low-intensity exercise
Price T, Rothman D, Avison M, Buonamico P, Shulman R. 13C-NMR measurements of muscle glycogen during low-intensity exercise. Journal Of Applied Physiology 1991, 70: 1836-1844. PMID: 2055862, DOI: 10.1152/jappl.1991.70.4.1836.Peer-Reviewed Original ResearchConceptsLow-intensity exerciseMuscle glycogenLight exerciseProtocol 1Blood velocityHours of exerciseMaximum voluntary contractionMin of onsetExercised legNonexercised legFemoral arteryVoluntary contractionGlycogen repletionHeavy exercisePlantar flexionGastrocnemius muscleFemale subjectsGlycogen levelsGlycogen metabolismFive minutesExerciseGlycogenSubjectsMagnetic resonance spectroscopyLeg
1989
Natural-abundance 13C NMR study of glycogen repletion in human liver and muscle.
Jue T, Rothman D, Tavitian B, Shulman R. Natural-abundance 13C NMR study of glycogen repletion in human liver and muscle. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 1439-1442. PMID: 2922392, PMCID: PMC286711, DOI: 10.1073/pnas.86.5.1439.Peer-Reviewed Original Research
1988
Detection of human muscle glycogen by natural abundance 13C NMR.
Avison M, Rothman D, Nadel E, Shulman R. Detection of human muscle glycogen by natural abundance 13C NMR. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 1634-1636. PMID: 3422752, PMCID: PMC279828, DOI: 10.1073/pnas.85.5.1634.Peer-Reviewed Original Research
1984
Carbon-13 nuclear magnetic resonance studies of myocardial glycogen metabolism in live guinea pigs.
Neurohr K, Gollin G, Neurohr J, Rothman D, Shulman R. Carbon-13 nuclear magnetic resonance studies of myocardial glycogen metabolism in live guinea pigs. Biochemistry 1984, 23: 5029-35. PMID: 6498174, DOI: 10.1021/bi00316a031.Peer-Reviewed Original Research