1994
Proton spectroscopy of human stroke: Assessment of transverse relaxation times and partial volume effects in single volume STEAM MRS
Blamire A, Graham G, Rothman D, Prichard J. Proton spectroscopy of human stroke: Assessment of transverse relaxation times and partial volume effects in single volume STEAM MRS. Magnetic Resonance Imaging 1994, 12: 1227-1235. PMID: 7854028, DOI: 10.1016/0730-725x(94)90087-8.Peer-Reviewed Original ResearchConceptsStroke patientsAge-matched normal subjectsHuman strokeSpin-echo MRINormal subjectsNormal brainPatientsInfarcted tissueProton T2 relaxation timesInverse correlationHigh inverse correlationT2 relaxation timesCholine resonanceSignificant differencesProton spectroscopyPercentage volumeT2 valuesT. SpectraPartial volume effectsPeak amplitudeSTEAM sequence
1993
Early temporal variation of cerebral metabolites after human stroke. A proton magnetic resonance spectroscopy study.
Graham G, Blamire A, Rothman D, Brass L, Fayad P, Petroff O, Prichard J. Early temporal variation of cerebral metabolites after human stroke. A proton magnetic resonance spectroscopy study. Stroke 1993, 24: 1891-1896. PMID: 8248973, DOI: 10.1161/01.str.24.12.1891.Peer-Reviewed Original ResearchConceptsAcetyl-aspartate signalProton magnetic resonance spectroscopyCerebral infarctionProton magnetic resonance spectroscopy studyLactate signalAbundant leukocyte infiltrationAcetyl-aspartate peakNonhemorrhagic cerebral infarctionAcute cerebral infarctionDays of strokeMagnetic resonance spectroscopy studyContralateral normal brainClearance of lactateCreatine/phosphocreatineMagnetic resonance spectroscopyLong-term elevationLate deathsHuman strokeSubacute stageLeukocyte infiltrationChronic periodLesion volumeCerebral metabolitesInfarct zoneSecond examination
1992
Spectroscopic imaging of stroke in humans: histopathology correlates of spectral changes.
Petroff O, Graham G, Blamire A, Al-Rayess M, Rothman D, Fayad P, Brass L, Shulman R, Prichard J. Spectroscopic imaging of stroke in humans: histopathology correlates of spectral changes. Neurology 1992, 42: 1349-54. PMID: 1620345, DOI: 10.1212/wnl.42.7.1349.Peer-Reviewed Original ResearchConceptsCells/mm2Foamy macrophagesElevation of lactateGlial densityNeuropathologic examinationBrain macrophagesHuman strokeHistopathology correlateMacrophage densityInfarctsHigh lactateHistopathologic sectionsStrokeLactate concentrationMedial marginMacrophagesLactate signalMonthsLactate poolWeeksLactateCellular localizationMetabolic turnoverMagnetic resonanceMagnetic resonance spectroscopy