2004
UVB-induced apoptosis drives clonal expansion during skin tumor development
Zhang W, Hanks AN, Boucher K, Florell SR, Allen SM, Alexander A, Brash DE, Grossman D. UVB-induced apoptosis drives clonal expansion during skin tumor development. Carcinogenesis 2004, 26: 249-257. PMID: 15498793, PMCID: PMC2292404, DOI: 10.1093/carcin/bgh300.Peer-Reviewed Original Research
2003
A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen
Xue D, Shi H, Smith JD, Chen X, Noe DA, Cedervall T, Yang DD, Eynon E, Brash DE, Kashgarian M, Flavell RA, Wolin SL. A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 7503-7508. PMID: 12788971, PMCID: PMC164616, DOI: 10.1073/pnas.0832411100.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantigensB-LymphocytesCrosses, GeneticDose-Response Relationship, RadiationGlomerulonephritis, MembranoproliferativeHeterozygoteKidneyLupus VulgarisMiceMice, Inbred C57BLMice, TransgenicModels, GeneticRibonucleoproteinsRibosomesRNARNA, Small CytoplasmicSubcellular FractionsSyndromeT-LymphocytesUltraviolet RaysConceptsRo antibodiesRo 60Complete congenital heart blockLupus-like syndromeCongenital heart blockSystemic lupus erythematosusAnti-Ro antibodiesRo proteinAnti-chromatin antibodiesPhotosensitive skin lesionsNeonatal lupusAutoimmune syndromeLupus erythematosusHeart blockCutaneous lesionsAutoantibody developmentImmune surveillanceSkin lesionsHuman autoantigensSyndromeAntibodiesMiceLupusPatientsAutoantigens
2001
Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53
Grossman D, Kim P, Blanc-Brude O, Brash D, Tognin S, Marchisio P, Altieri D. Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53. Journal Of Clinical Investigation 2001, 108: 991-999. PMID: 11581300, PMCID: PMC200956, DOI: 10.1172/jci13345.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisChromosomal Proteins, Non-HistoneGene ExpressionHumansInhibitor of Apoptosis ProteinsKeratin-14KeratinocytesKeratinsMiceMice, KnockoutMice, TransgenicMicrotubule-Associated ProteinsNeoplasm ProteinsPhenotypePromoter Regions, GeneticSkinSurvivinTumor Suppressor Protein p53Ultraviolet Rays