2017
Fluorouracil Enhances Photodynamic Therapy of Squamous Cell Carcinoma via a p53-Independent Mechanism that Increases Protoporphyrin IX levels and Tumor Cell Death
Anand S, Rollakanti KR, Brankov N, Brash DE, Hasan T, Maytin EV. Fluorouracil Enhances Photodynamic Therapy of Squamous Cell Carcinoma via a p53-Independent Mechanism that Increases Protoporphyrin IX levels and Tumor Cell Death. Molecular Cancer Therapeutics 2017, 16: 1092-1101. PMID: 28336806, PMCID: PMC5497500, DOI: 10.1158/1535-7163.mct-16-0608.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiosynthetic PathwaysCarcinoma, Squamous CellCell DeathCell Line, TumorCell ProliferationCombined Modality TherapyDisease Models, AnimalFluorouracilGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticHemeHumansMicePhotochemotherapyProtoporphyrinsTumor Suppressor Protein p53Xenograft Model Antitumor AssaysConceptsSquamous cell carcinomaActinic keratosesPhotodynamic therapyP53-null tumorsNew therapeutic approachesMol Cancer TherCell deathCell carcinomaTherapeutic responsePpIX levelsTherapeutic approachesMouse modelSkin cancerSCC precursorsHeme synthesis pathwayTumorsKeratosesDeathP53PDT efficacyInductionPretreatmentNeoadjuvantCombination approachSurgery
1993
Local recurrence versus new primary: Clinical analysis of 82 breast relapses and potential applications for genetic fingerprinting
Haffty B, Carter D, Flynn S, Fischer D, Brash D, Simons J, Ziegler A, Fischer J. Local recurrence versus new primary: Clinical analysis of 82 breast relapses and potential applications for genetic fingerprinting. International Journal Of Radiation Oncology • Biology • Physics 1993, 27: 575-583. PMID: 8226151, DOI: 10.1016/0360-3016(93)90382-6.Peer-Reviewed Original ResearchConceptsNew primary tumorsBreast relapsePrimary tumorTrue recurrenceNew primaryConservative surgeryLocal recurrencePathological criteriaRadiation therapyOriginal tumorSurvival rateClinical pathological analysisSecond primary tumorsShorter median timeTrue local recurrenceSignificant prognostic implicationsDNA flow cytometryLocal relapseMedian timePrognostic implicationsResidual diseaseTumor bedPathological analysisRelapseTherapeutic implications