2018
Chemiexcitation and Its Implications for Disease
Brash DE, Goncalves LCP, Bechara EJH, Group T. Chemiexcitation and Its Implications for Disease. Trends In Molecular Medicine 2018, 24: 527-541. PMID: 29751974, PMCID: PMC5975183, DOI: 10.1016/j.molmed.2018.04.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHigh-energy processesQuantum mechanicsMolecular orbitalsTransfer energyHighest energy molecular orbitalChemiexcitationUltraviolet lightMutagenic cyclobutane pyrimidine dimersNumerous human diseasesPhotonsElectronsCyclobutane pyrimidine dimersOrbitalsHuman diseasesUpstream eventsPigment melaninEnergy
2015
Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure
Premi S, Wallisch S, Mano CM, Weiner AB, Bacchiocchi A, Wakamatsu K, Bechara EJ, Halaban R, Douki T, Brash DE. Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure. Science 2015, 347: 842-847. PMID: 25700512, PMCID: PMC4432913, DOI: 10.1126/science.1256022.Peer-Reviewed Original ResearchConceptsDark cyclobutane pyrimidine dimersExcited electronic statesUltraviolet photonsUV photonsElectronic statesTriplet stateSunlight-induced melanomaCytosine-containing cyclobutane pyrimidine dimersEnergy transferPhotonsPicosecondsElectronsUV exposureRadiationChemiexcitationEnergyStatePhotoproducts