A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen
Xue D, Shi H, Smith JD, Chen X, Noe DA, Cedervall T, Yang DD, Eynon E, Brash DE, Kashgarian M, Flavell RA, Wolin SL. A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 7503-7508. PMID: 12788971, PMCID: PMC164616, DOI: 10.1073/pnas.0832411100.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantigensB-LymphocytesCrosses, GeneticDose-Response Relationship, RadiationGlomerulonephritis, MembranoproliferativeHeterozygoteKidneyLupus VulgarisMiceMice, Inbred C57BLMice, TransgenicModels, GeneticRibonucleoproteinsRibosomesRNARNA, Small CytoplasmicSubcellular FractionsSyndromeT-LymphocytesUltraviolet RaysConceptsRo antibodiesRo 60Complete congenital heart blockLupus-like syndromeCongenital heart blockSystemic lupus erythematosusAnti-Ro antibodiesRo proteinAnti-chromatin antibodiesPhotosensitive skin lesionsNeonatal lupusAutoimmune syndromeLupus erythematosusHeart blockCutaneous lesionsAutoantibody developmentImmune surveillanceSkin lesionsHuman autoantigensSyndromeAntibodiesMiceLupusPatientsAutoantigens