2006
HIV-1 infection and fertility in Dar es Salaam, Tanzania.
Sedgh G, Larsen U, Spiegelman D, Msamanga G, Fawzi WW. HIV-1 infection and fertility in Dar es Salaam, Tanzania. African Journal Of Reproductive Health 2006, 10: 41-52. PMID: 17518130, DOI: 10.2307/30032470.Peer-Reviewed Original ResearchConceptsHIV-1 infectionUninfected womenHIV infectionPregnancy lossMultivariate analysisHIV-1 infected womenPregnancy rate ratioRetrospective cohort studyPredictors of pregnancyHIV-positive womenNumber of pregnanciesRate of pregnancyDar es SalaamHigher pregnancy rateAdvanced diseaseCohort studyHIV seropositivityInfected womenBorderline significancePregnancy rateAdvanced stageInfectionPregnancyWomenRate ratioSocio-economic and demographic factors associated with prevalence of HIV infection among pregnant women in Dar es Salaam, Tanzania
Msamanga G, Fawzi W, Hertzmark E, McGrath N, Kapiga S, Kagoma C, Spiegelman D, Hunter D. Socio-economic and demographic factors associated with prevalence of HIV infection among pregnant women in Dar es Salaam, Tanzania. East African Medical Journal 2006, 83: 311-321. PMID: 16989376, DOI: 10.4314/eamj.v83i6.9438.Peer-Reviewed Original ResearchConceptsHIV infectionAntenatal clinicHIV-1-positive womenDar es SalaamMaternal-foetal transmissionMid-arm circumferenceHIV-1 infectionDemographic characteristicsLow HIV prevalenceCross-sectional studyHIV prevalence ratesHIV/AIDS epidemicOpt-out approachLow-resource settingsPositive womenNevirapine treatmentHIV prevalencePregnant womenMaternal ageHigh prevalenceRegular partnersPrevalence ratesPartner's occupationTanzanian womenOlder age
2005
Predictors of Bone Mineral Density in Human Immunodeficiency Virus‐1 Infected Children
Jacobson DL, Spiegelman D, Duggan C, Weinberg GA, Bechard L, Furuta L, Nicchitta J, Gorbach SL, Miller TL. Predictors of Bone Mineral Density in Human Immunodeficiency Virus‐1 Infected Children. Journal Of Pediatric Gastroenterology And Nutrition 2005, 41: 339-346. PMID: 16131991, DOI: 10.1097/01.mpg.0000174468.75219.30.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAntiretroviral Therapy, Highly ActiveBlack or African AmericanBody CompositionBody HeightBody Mass IndexBody WeightBone DensityCase-Control StudiesChildChild DevelopmentCross-Sectional StudiesFemaleHispanic or LatinoHIV InfectionsHIV-1HumansLongitudinal StudiesMalePredictive Value of TestsProspective StudiesSeverity of Illness IndexVitaminsWhite PeopleConceptsBMD Z-scoresBone mineral densityLower BMD Z-scoresMineral densityZ-scorePopulation normsMultivitamin useDietary intakePredictors of BMDTotal body bone mineral densityLower weight z-scoreBody bone mineral densityLow bone mineral densitySibling controlsBetter bone mineral densityDual-energy X-ray absorptiometry (DXA) examinationDual-energy X-ray absorptiometryLower height Z-scoresHuman immunodeficiency virus-1Energy X-ray absorptiometryAdvanced HIV stageAge-adjusted percentileIndependent risk factorGender-adjusted z-scoresWeight z-scoreSelenium status, pregnancy outcomes, and mother-to-child transmission of HIV-1.
Kupka R, Garland M, Msamanga G, Spiegelman D, Hunter D, Fawzi W. Selenium status, pregnancy outcomes, and mother-to-child transmission of HIV-1. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2005, 39: 203-10. PMID: 15905738.Peer-Reviewed Original ResearchConceptsPregnancy outcomesPregnant womenChild transmissionLow selenium statusHIV transmissionMaternal HIV disease progressionHIV-positive pregnant womenSelenium statusDirect epidemiologic evidenceMTCT of HIVLow plasma selenium levelsHIV disease progressionPoor pregnancy outcomesRisk of motherWeeks of gestationMother-child pairsPlasma selenium levelsAdequate selenium statusFetal deathGestational ageEpidemiologic evidenceLow birthweightDisease progressionGenital tractHIV-1
2004
Selenium Status Is Associated with Accelerated HIV Disease Progression among HIV-1–Infected Pregnant Women in Tanzania
Kupka R, Msamanga GI, Spiegelman D, Morris S, Mugusi F, Hunter DJ, Fawzi WW. Selenium Status Is Associated with Accelerated HIV Disease Progression among HIV-1–Infected Pregnant Women in Tanzania. Journal Of Nutrition 2004, 134: 2556-2560. PMID: 15465747, DOI: 10.1093/jn/134.10.2556.Peer-Reviewed Original ResearchConceptsPlasma selenium levelsCD4 cell countRisk of mortalityDisease progressionHIV-1-infected pregnant womenCell countSelenium levelsLow plasma selenium levelsHIV disease progressionAccelerated disease progressionCox multivariate modelSelenium statusMedian followHIV diseaseClinical outcomesPregnant womenPoor survivalTanzanian womenMultivariate modelL increaseCells/ProgressionWomenMortalityFirst yearAssociation Between Low Birth Weight and Infant Mortality in Children Born to Human Immunodeficiency Virus 1-Infected Mothers in Tanzania
Wei R, Msamanga GI, Spiegelman D, Hertzmark E, Baylin A, Manji K, Fawzi WW. Association Between Low Birth Weight and Infant Mortality in Children Born to Human Immunodeficiency Virus 1-Infected Mothers in Tanzania. The Pediatric Infectious Disease Journal 2004, 23: 530-535. PMID: 15194834, DOI: 10.1097/01.inf.0000129691.42964.eb.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceCohort StudiesConfidence IntervalsDeveloping CountriesFemaleHIV InfectionsHIV-1HumansIncidenceInfant MortalityInfant, Low Birth WeightInfant, NewbornInfectious Disease Transmission, VerticalMalePregnancyPregnancy Complications, InfectiousPregnancy OutcomeProportional Hazards ModelsRisk FactorsSex DistributionSurvival AnalysisTanzaniaConceptsLow birth weightBirth weightHIV statusHIV transmissionInfant mortalityCox proportional hazards modelHuman immunodeficiency virus-1Child's HIV statusPediatric HIV infectionHuman immunodeficiency virusRisk of mortalityImmunodeficiency virus-1Proportional hazards modelWeeks of ageAntiretroviral treatmentHIV infectionImmunodeficiency virusNeonatal mortalityPositive infantsPregnant womenPostneonatal mortalityHazards modelMortalityInfantsVirus 1Breastfeeding and maternal HIV-1 disease progression and mortality
Sedgh G, Spiegelman D, Larsen U, Msamanga G, Fawzi WW. Breastfeeding and maternal HIV-1 disease progression and mortality. AIDS 2004, 18: 1043-1049. PMID: 15096808, DOI: 10.1097/00002030-200404300-00013.Peer-Reviewed Original ResearchConceptsHIV-1 disease progressionCD4 cell countDisease progressionCell countHigher CD4 cell countsLow CD4 cell countsCox proportional hazards modelHealth of HIVCohort study designExcessive weight lossProportional hazards modelPartial breastfeedingRelative riskHazards modelInsufficient evidenceBreastfeedingMultivariate analysisStudy designWeight lossWomenProgressionDar es SalaamHIVDeathAssociationEffect of Prenatal Vitamin Supplementation on Lower-Genital Levels of HIV Type 1 and Interleukin Type 1β at 36 Weeks of Gestation
Fawzi W, Msamanga G, Antelman G, Xu C, Hertzmark E, Spiegelman D, Hunter D, Anderson D. Effect of Prenatal Vitamin Supplementation on Lower-Genital Levels of HIV Type 1 and Interleukin Type 1β at 36 Weeks of Gestation. Clinical Infectious Diseases 2004, 38: 716-722. PMID: 14986257, DOI: 10.1086/381673.Peer-Reviewed Original ResearchConceptsHIV-1HIV-1-infected pregnant womenVitamin AHIV-1-infected womenType 1Human immunodeficiency virus type 1Immunodeficiency virus type 1Genital HIV-1Prenatal multivitamin supplementsHIV-1 transmissionCervicovaginal lavage specimensHIV Type 1HIV-1 infectionLower genital tractWeeks of gestationPrenatal vitamin supplementationUse of vitaminsVirus type 1Lack of effectPregnancy outcomesVaginal inflammationViral sheddingVitamin supplementationMultivitamin supplementsPregnant womenEstimating treatment effects in studies of perinatal transmission of HIV
Bang H, Spiegelman D. Estimating treatment effects in studies of perinatal transmission of HIV. Biostatistics 2004, 5: 31-43. PMID: 14744826, DOI: 10.1093/biostatistics/5.1.31.Peer-Reviewed Original Research
2003
Pattern and Predictors of Weight Gain During Pregnancy Among HIV-1–Infected Women from Tanzania
Villamor E, Msamanga G, Spiegelman D, Peterson KE, Antelman G, Fawzi WW. Pattern and Predictors of Weight Gain During Pregnancy Among HIV-1–Infected Women from Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2003, 32: 560-569. PMID: 12679710, DOI: 10.1097/00126334-200304150-00015.Peer-Reviewed Original ResearchMeSH KeywordsArmBody Mass IndexCohort StudiesFemaleHIV InfectionsHIV-1HumansMalaria, FalciparumNutritional StatusPredictive Value of TestsPregnancyPregnancy Complications, InfectiousPregnancy Complications, ParasiticPregnancy Trimester, SecondPregnancy Trimester, ThirdTanzaniaVitamin AVitaminsWeight GainConceptsMid-upper arm circumferenceGestational weight gainWeight gainHIV diseaseThird trimesterLower baseline CD4 T cell countsBaseline CD4 T-cell countHIV-1-infected womenCD4 T-cell countLow serum retinolT-cell countsFirst prenatal visitHIV-positive womenAdvanced clinical stageMonthly anthropometric measurementsNeonatal outcomesPrenatal visitWeek 12Clinical stagePregnant womenSecond trimesterArm circumferenceMalaria infectionSerum retinolHelminthic infections
2002
Transmission of HIV-1 Through Breastfeeding Among Women in Dar es Salaam, Tanzania
Fawzi W, Msamanga G, Spiegelman D, Renjifo B, Bang H, Kapiga S, Coley J, Hertzmark E, Essex M, Hunter D. Transmission of HIV-1 Through Breastfeeding Among Women in Dar es Salaam, Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2002, 31: 331-338. PMID: 12439210, DOI: 10.1097/00126334-200211010-00010.Peer-Reviewed Original ResearchConceptsHIV-1High maternal viral loadLow CD4 cell countsMultivariate proportional hazards modelMaternal viral loadCD4 cell countHIV-1 transmissionErythrocyte sedimentation rateAge 6 weeksAge 4 monthsChildren of womenProportional hazards modelDar es SalaamAge 24 monthsAnalysis of correlatesNipple cracksChild transmissionImmune reconstitutionCumulative incidenceViral loadPregnant womenAntiretroviral drugsMean durationMicronutrient supplementsHigh riskEffect of multivitamin and vitamin A supplements on weight gain during pregnancy among HIV-1-infected women 1 , 2 , 3
Villamor E, Msamanga G, Spiegelman D, Antelman G, Peterson KE, Hunter DJ, Fawzi WW. Effect of multivitamin and vitamin A supplements on weight gain during pregnancy among HIV-1-infected women 1 , 2 , 3. American Journal Of Clinical Nutrition 2002, 76: 1082-1090. PMID: 12399282, DOI: 10.1093/ajcn/76.5.1082.Peer-Reviewed Original ResearchConceptsEffects of multivitaminsThird trimesterWeight gainVitamin AMultivitamin supplementationSecond trimesterHIV-1-positive womenAdverse pregnancy outcomesPlacebo-controlled trialGestational weight gainHIV-positive womenEnd of pregnancyPregnancy outcomesOral supplementsAverage weight gainProtective effectTrimesterLower weight gainMultivitaminsPregnancyWomen 1HIVWomenDar es SalaamLower ratesRandomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality
Fawzi WW, Msamanga GI, Hunter D, Renjifo B, Antelman G, Bang H, Manji K, Kapiga S, Mwakagile D, Essex M, Spiegelman D. Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality. AIDS 2002, 16: 1935-1944. PMID: 12351954, DOI: 10.1097/00002030-200209270-00011.Peer-Reviewed Original ResearchConceptsHIV-1 transmissionInfants of mothersVitamin ALower baseline lymphocyte countsHigh erythrocyte sedimentation rateChild mortalityBaseline lymphocyte countMaternal micronutrient statusHIV-free survivalErythrocyte sedimentation rateLow birthweight babiesEarly child mortalityRisk of transmissionLymphocyte countLower hemoglobinMultivitamin supplementationWeeks' gestationBirthweight babiesPregnant womenHIV-1Vitamin supplementsMultivitaminsNutritional statusMicronutrient statusMortalityCorrelates of Plasma HIV-1 RNA Viral Load Among HIV-1 Seropositive Women in Dar es Salaam, Tanzania
Kapiga SH, Bang H, Spiegelman D, Msamanga GI, Coley J, Hunter DJ, Fawzi WW. Correlates of Plasma HIV-1 RNA Viral Load Among HIV-1 Seropositive Women in Dar es Salaam, Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2002, 30: 316-323. PMID: 12131569, DOI: 10.1097/01.qai.0000014767.47046.c8.Peer-Reviewed Original ResearchConceptsHIV-1 RNA viral loadRNA viral loadPlasma HIV-1 RNA viral loadViral loadCopies/mLLymphocyte countHIV-1 positive pregnant womenHIV-1-seropositive womenMedian viral loadHigh viral loadPrevention of malariaTime of deliverySeropositive womenAbsolute CD4Pregnant womenClinical trialsHIV-1Long-term effectsDaily food expenditureMalaria parasitesBaselineMonthsDar es SalaamCD4Food expenditure
2001
HIV-1 LTR Subtype and Perinatal Transmission
Blackard J, Renjifo B, Fawzi W, Hertzmark E, Msamanga G, Mwakagile D, Hunter D, Spiegelman D, Sharghi N, Kagoma C, Essex M. HIV-1 LTR Subtype and Perinatal Transmission. Virology 2001, 287: 261-265. PMID: 11531404, DOI: 10.1006/viro.2001.1059.Peer-Reviewed Original ResearchDo HIV Type 1 RNA Levels Provide Additional Prognostic Value to CD4+ T Lymphocyte Counts in Patients with Advanced HIV Type 1 Infection?
Arduino J, Fischl M, Stanley K, Collier A, Spiegelman D. Do HIV Type 1 RNA Levels Provide Additional Prognostic Value to CD4+ T Lymphocyte Counts in Patients with Advanced HIV Type 1 Infection? AIDS Research And Human Retroviruses 2001, 17: 1099-1105. PMID: 11522179, DOI: 10.1089/088922201316912709.Peer-Reviewed Original ResearchConceptsHIV-1 RNA levelsHIV-1 disease progressionBaseline HIV-1 RNA levelsT-lymphocyte countsT lymphocytesDisease progressionLymphocyte countRNA levelsCells/Prognostic informationHigh baseline HIV-1 RNA levelsHIV type 1 RNA levelsPlasma HIV-1 RNA levelsSubsequent HIV-1 disease progressionAdvanced HIV-1 diseaseHIV Type 1 InfectionConditional logistic regression analysisDisease progression independentHIV-1 diseaseAdditional prognostic informationAdditional prognostic valueType 1 infectionCase-control studyLogistic regression analysisClinical statusPredictors of intrauterine and intrapartum transmission of HIV-1 among Tanzanian women
Fawzi W, Msamanga G, Renjifo B, Spiegelman D, Urassa E, Hashemi L, Antelman G, Essex M, Hunter D. Predictors of intrauterine and intrapartum transmission of HIV-1 among Tanzanian women. AIDS 2001, 15: 1157-1165. PMID: 11416718, DOI: 10.1097/00002030-200106150-00011.Peer-Reviewed Original ResearchConceptsViral loadHIV-1HIV-1-infected pregnant womenLower genital tract infectionMaternal CD4 cell countVertical transmissionLower genital infectionsMaternal viral loadCD4 cell countGenital tract infectionHIV disease progressionHIV-1 infectionWeeks of gestationPrevention of transmissionIntrapartum transmissionIntrauterine transmissionGenital infectionTract infectionsSustained clearanceClinical stagePregnant womenPrenatal careDisease progressionCopies/Vitamin supplementsDifferences in perinatal transmission among human immunodeficiency virus type 1 genotypes.
Renjifo B, Fawzi W, Mwakagile D, Hunter D, Msamanga G, Spiegelman D, Garland M, Kagoma C, Kim A, Chaplin B, Hertzmark E, Essex M. Differences in perinatal transmission among human immunodeficiency virus type 1 genotypes. Human Virology 2001, 4: 16-25. PMID: 11213929.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCapsidCapsid ProteinsCase-Control StudiesDNA, ViralDouble-Blind MethodFemaleGag Gene Products, Human Immunodeficiency VirusGene Products, envGene Products, gagGenotypeHIV Core Protein p24HIV InfectionsHIV-1HumansInfantInfant, NewbornMolecular Sequence DataRisk FactorsViral ProteinsConceptsHIV-1 genetic subtypesCD4 cell countHIV-1 genotypesCell countGenetic subtypesHIV-1 subtype AHIV-1 subtype CHuman immunodeficiency virus type 1Vertical transmissionHuman immunodeficiency virus type 1 genotypesImmunodeficiency virus type 1Intersubtype recombinant virusesMaternal risk factorsLogistic regression analysisType 1 genotypeVirus type 1HIV-1 GagPerinatal transmissionSubtype CRisk factorsSubtype AHIV-1Intersubtype recombinantsType 1Differential risk
2000
Risk factors for HIV-1 seroprevalence among family planning clients in Dar es Salaam, Tanzania.
Kapiga SH, Lyamuya EF, Vuylsteke B, Spiegelman D, Larsen U, Hunter DJ. Risk factors for HIV-1 seroprevalence among family planning clients in Dar es Salaam, Tanzania. African Journal Of Reproductive Health 2000, 4: 88-99. PMID: 11000712, DOI: 10.2307/3583246.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionCross-Sectional StudiesFamily Planning ServicesFemaleHealth Knowledge, Attitudes, PracticeHIV SeroprevalenceHIV-1HumansMarital StatusOccupationsRisk FactorsSexually Transmitted DiseasesSocioeconomic FactorsSurveys and QuestionnairesTanzaniaUrban PopulationWomenConceptsRisk of HIVRisk factorsMajor public health problemHIV-1 seroprevalenceHIV risk factorsPrevalence of HIVCross-sectional studyPublic health problemDar es SalaamFamily planning servicesHIV infectionHIV testingFP clientsHIV interventionsHIVLaboratory evidenceHealth problemsLarge clinicsPlanning servicesWomenRiskMarried womenFurther spreadSeroprevalenceClinicPredictors of CD4+ lymphocyte count among HIV-Seropositive and HIV-Seronegative pregnant women in Dar Es Salaam, Tanzania
Kapiga SH, Mwakagile D, Spiegelman D, Msamanga GI, Hunter D, Fawzi WW. Predictors of CD4+ lymphocyte count among HIV-Seropositive and HIV-Seronegative pregnant women in Dar Es Salaam, Tanzania. East African Medical Journal 2000, 77: 206-11. PMID: 12858905, DOI: 10.4314/eamj.v77i4.46622.Peer-Reviewed Original ResearchConceptsHIV-seropositive womenCells/mm3Erythrocyte sedimentation rateHIV-seronegative pregnant womenWhite blood countLymphocyte countPredictors of CD4Pregnant womenHIV-seropositiveMost HIV-seropositive womenTotal white blood countHaematological indicesReduction of CD4HIV-seronegative womenT lymphocyte subsetsClinical stage 1Age 25 yearsDar es SalaamAverage age 25 yearsAsymptomatic womenBlood countSocio-demographic characteristicsCD4Blood samplesHR increase