Featured Publications
Cell-Extracellular Matrix Interactions Play Multiple Essential Roles in Aortic Arch Development
Warkala M, Chen D, Ramirez A, Jubran A, Schonning M, Wang X, Zhao H, Astrof S. Cell-Extracellular Matrix Interactions Play Multiple Essential Roles in Aortic Arch Development. Circulation Research 2020, 128: e27-e44. PMID: 33249995, PMCID: PMC7864893, DOI: 10.1161/circresaha.120.318200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, ThoracicCell LineageCell-Matrix JunctionsEndothelial Progenitor CellsExtracellular MatrixExtracellular Matrix ProteinsFibronectinsGene Expression Regulation, DevelopmentalGestational AgeIntegrin alpha5beta1LIM-Homeodomain ProteinsMice, 129 StrainMice, Inbred C57BLMice, KnockoutMorphogenesisSignal TransductionTranscription FactorsConceptsSecond heart fieldPharyngeal arch arteriesCell-ECM interactionsPAA formationAortic arch arteriesPharyngeal archesArch arteriesIntegrin α5β1Whole-mount confocal imagingEssential roleCell-extracellular matrix interactionsFourth pharyngeal arch arteryMultiple essential rolesEndothelial cell dynamicsNeural crest-derived cellsCrest-derived cellsLethal birth defectEC progenitorsUnderstanding genesHeart fieldLineage tracingVascular smooth muscle cellsMorphogenesisAortic arch developmentDevelopmental stages
2019
FRS2α-dependent cell fate transition during endocardial cushion morphogenesis
Chen D, Zhu X, Kofler N, Wang Y, Zhou B, Simons M. FRS2α-dependent cell fate transition during endocardial cushion morphogenesis. Developmental Biology 2019, 458: 88-97. PMID: 31669335, DOI: 10.1016/j.ydbio.2019.10.022.Peer-Reviewed Original ResearchConceptsCell fate transitionsFate transitionsAtrioventricular valve developmentInducible endothelial-specific deletionPivotal controllerEmbryonic developmentEndothelial-specific deletionFRS2αValve developmentEndocardial cushionsEndocardial cellsMesenchymal transitionMesenchymal cellsAV cushionsDefective maturationDevelopmental abnormalitiesDeletionAdult endothelium