Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
Lötscher J, Martí I Líndez AA, Kirchhammer N, Cribioli E, Giordano Attianese G, Trefny MP, Lenz M, Rothschild SI, Strati P, Künzli M, Lotter C, Schenk SH, Dehio P, Löliger J, Litzler L, Schreiner D, Koch V, Page N, Lee D, Grählert J, Kuzmin D, Burgener AV, Merkler D, Pless M, Balmer ML, Reith W, Huwyler J, Irving M, King CG, Zippelius A, Hess C. Magnesium sensing via LFA-1 regulates CD8+ T cell effector function. Cell 2022, 185: 585-602.e29. PMID: 35051368, DOI: 10.1016/j.cell.2021.12.039.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacterial InfectionsCaloric RestrictionCD8-Positive T-LymphocytesCell Line, TumorCytotoxicity, ImmunologicHEK293 CellsHumansImmunologic MemoryImmunological SynapsesImmunotherapyLymphocyte ActivationLymphocyte Function-Associated Antigen-1MagnesiumMaleMAP Kinase Signaling SystemMice, Inbred C57BLNeoplasmsPhenotypePhosphorylationProto-Oncogene Proteins c-junConceptsLFA-1CAR TLow serum magnesium levelsMore rapid disease progressionAntibody-treated patientsRapid disease progressionShorter overall survivalSerum magnesium levelsCell effector functionsOverall survivalCellular immunityImmune synapse formationDisease progressionEffector functionsExtracellular magnesiumSpecific cytotoxicityMagnesium levelsSynapse formationCalcium fluxCell functionMetabolic reprogrammingCD8CellsNutrient sensingPatients