2001
Genomics-based identification of targets in pathogenic bacteria for potential therapeutic and diagnostic use
Raczniak G, Ibba M, Söll D. Genomics-based identification of targets in pathogenic bacteria for potential therapeutic and diagnostic use. Toxicology 2001, 160: 181-189. PMID: 11246138, DOI: 10.1016/s0300-483x(00)00454-6.Peer-Reviewed Original ResearchConceptsComplete microbial genome sequencesMicrobial genome sequencesFundamental biological processesPathogen-specific pathwaysAminoacyl-tRNA synthesisGenome sequenceBiochemical approachesMammalian hostsIdentification of targetsBiological processesNumber of pathogensProtein synthesisPharmaceutical exploitationSynthesis pathwayCertain pathwaysNovel targetPathogenic bacteriaEnzyme presentPathwayDiagnostic targetsCell viabilityKey processesGenomicsRecent advancesTarget
2000
AMINOACYL-tRNA SYNTHESIS
Ibba M, Söll D. AMINOACYL-tRNA SYNTHESIS. Annual Review Of Biochemistry 2000, 69: 617-650. PMID: 10966471, DOI: 10.1146/annurev.biochem.69.1.617.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacteriaBacterial InfectionsBiological EvolutionEnzyme InhibitorsHumansModels, MolecularRNA, Transfer, Amino AcylConceptsAminoacyl-tRNA synthesisAmino acidsAminoacyl-tRNA synthetaseEvolutionary facetsWhole-genome sequencingCorresponding tRNAsGenetic codeGenome sequencingAminoacyl-tRNACorresponding anticodonTRNACurrent knowledgeStructural dataRecent studiesAnticodonDetailed pictureAcidSequencingSynthetaseEditingProofreadingSynthesisTranslationDirect attachment
1999
The RCN1‐encoded A subunit of protein phosphatase 2A increases phosphatase activity in vivo
Deruère J, Jackson K, Garbers C, Söll D, DeLong A. The RCN1‐encoded A subunit of protein phosphatase 2A increases phosphatase activity in vivo. The Plant Journal 1999, 20: 389-399. PMID: 10607292, DOI: 10.1046/j.1365-313x.1999.00607.x.Peer-Reviewed Original ResearchConceptsProtein phosphatase 2AMutant seedlingsOrgan elongationPhosphatase 2ARegulatory subunitSerine/threonine-specific protein phosphataseT-DNA insertion mutationPhosphatase inhibitor okadaic acidCatalytic C subunitWild-type seedlingsDistinct regulatory subunitsLateral root primordiaInhibitor okadaic acidCell elongation responseLight-grown seedlingsCatalytic subunit expressionRcn1 mutationPP2A holoenzymeShoot meristemProtein phosphataseRCN1 geneC subunitLeaf primordiaElongation assaysPositive regulator