Abstract LB258: Branching cancer evolution biases the detection of epistatic interactions between driver mutations
Biswas D, Birkbak N, Herrero J, Swanton C. Abstract LB258: Branching cancer evolution biases the detection of epistatic interactions between driver mutations. Cancer Research 2021, 81: lb258-lb258. DOI: 10.1158/1538-7445.am2021-lb258.Peer-Reviewed Original ResearchDetection of epistatic interactionsEvolutionary dependenciesEpistatic interactionsCancer-typeCancer cell fractionDriver genesExome-sequencing dataCancer evolutionClonal mutationsCancer genomic datasetsTumor phylogenetic treePhylogenetic treeGenomic datasetsCancer genomesPan-cancer analysisMutation clonalityMissense mutationsMutation matrixClonal architectureGenesLife historyLung adenocarcinoma datasetSubclonal mutationsMutationsLung adenocarcinoma tumors