Cancer cell – Fibroblast crosstalk via HB-EGF, EGFR, and MAPK signaling promotes the expression of macrophage chemo-attractants in squamous cell carcinoma
Giangreco G, Rullan A, Naito Y, Biswas D, Liu Y, Hooper S, Nenclares P, Bhide S, Chon U Cheang M, Chakravarty P, Hirata E, Swanton C, Melcher A, Harrington K, Sahai E. Cancer cell – Fibroblast crosstalk via HB-EGF, EGFR, and MAPK signaling promotes the expression of macrophage chemo-attractants in squamous cell carcinoma. IScience 2024, 27: 110635. PMID: 39262776, PMCID: PMC11387794, DOI: 10.1016/j.isci.2024.110635.Peer-Reviewed Original ResearchTumor microenvironmentSquamous cell carcinoma cohortCancer cellsMacrophage chemo-attractantsSquamous cell carcinomaTumor-stroma crosstalkRecruitment of macrophagesExpression of CSF2Prognostic significanceCarcinoma cohortCell carcinomaPatient prognosisHB-EGFStromal fibroblastsCancer outcomesCancer progressionCancerMAPK signalingIndicator of signalingChemo-attractantsCellsFibroblastsCarcinomaExpressionEGFR