Abstract LB258: Branching cancer evolution biases the detection of epistatic interactions between driver mutations
Biswas D, Birkbak N, Herrero J, Swanton C. Abstract LB258: Branching cancer evolution biases the detection of epistatic interactions between driver mutations. Cancer Research 2021, 81: lb258-lb258. DOI: 10.1158/1538-7445.am2021-lb258.Peer-Reviewed Original ResearchDetection of epistatic interactionsEvolutionary dependenciesEpistatic interactionsCancer-typeCancer cell fractionDriver genesExome-sequencing dataCancer evolutionClonal mutationsCancer genomic datasetsTumor phylogenetic treePhylogenetic treeGenomic datasetsCancer genomesPan-cancer analysisMutation clonalityMissense mutationsMutation matrixClonal architectureGenesLife historyLung adenocarcinoma datasetSubclonal mutationsMutationsLung adenocarcinoma tumorsImpact of cancer evolution on immune surveillance and checkpoint inhibitor response
Wu Y, Biswas D, Swanton C. Impact of cancer evolution on immune surveillance and checkpoint inhibitor response. Seminars In Cancer Biology 2021, 84: 89-102. PMID: 33631295, PMCID: PMC9253787, DOI: 10.1016/j.semcancer.2021.02.013.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsCheckpoint inhibitor therapyCheckpoint inhibitorsIntratumour heterogeneityImmune surveillancePatient's response to immune checkpoint inhibitorsResponse to immune checkpoint inhibitorsCheckpoint inhibitor responseProportion of patientsStandard of carePredictive biomarkersStratify patientsImmune evasionDiagnostic accuracyInhibitor responseImmune systemMechanisms of genetic instabilityPatientsGenetic instabilityCancer evolutionTherapyCancerSurveillanceInhibitorsIntratumour