2023
Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification
Santos-Sacchi J, Bai J, Navaratnam D. Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification. Journal Of Neuroscience 2023, 43: 2460-2468. PMID: 36868859, PMCID: PMC10082455, DOI: 10.1523/jneurosci.2033-22.2023.Peer-Reviewed Original ResearchConceptsConformational switchingMammalian hearingMembrane motor proteinCochlear amplificationMotor protein prestinVoltage-sensor charge movementOuter hair cell electromotilityHair cell electromotilityProtein prestinMotor proteinsConformation switchingCharge movementPrestinPrestin activityCell membraneOHC electromotilityHair cell membraneElectromotilityTransmembrane voltageOrgan of CortiAmplificationMammalsMembrane capacitanceProtein
1997
Differential Distribution of Ca2+-Activated K+ Channel Splice Variants among Hair Cells along the Tonotopic Axis of the Chick Cochlea
Navaratnam D, Bell T, Tu T, Cohen E, Oberholtzer J. Differential Distribution of Ca2+-Activated K+ Channel Splice Variants among Hair Cells along the Tonotopic Axis of the Chick Cochlea. Neuron 1997, 19: 1077-1085. PMID: 9390520, DOI: 10.1016/s0896-6273(00)80398-0.Peer-Reviewed Original Research
1996
Proliferation in the auditory receptor epithelium mediated by a cyclic AMP–dependent signaling pathway
Navaratnam D, Su H, Scott S, Oberholtzer J. Proliferation in the auditory receptor epithelium mediated by a cyclic AMP–dependent signaling pathway. Nature Medicine 1996, 2: 1136-1139. PMID: 8837614, DOI: 10.1038/nm1096-1136.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthine8-Bromo Cyclic Adenosine MonophosphateAnimalsCarbazolesChickensCochleaColforsinCyclic AMPCyclic AMP-Dependent Protein KinasesDNA ReplicationEnzyme ActivationEnzyme InhibitorsGentamicinsHair Cells, AuditoryHearing Loss, SensorineuralIndolesIsoquinolinesOrgan Culture TechniquesPyrrolesRegenerationSignal TransductionSulfonamidesConceptsAuditory receptor epitheliumProtein kinase AHair cellsReplacement hair cellsReceptor epitheliumNew hair cellsProliferative responseRegenerative proliferationReceptor hair cellsKinase ASignaling pathwaysPKA inhibitorGentamicin damageCellular recoveryCyclic AMP levelsCell populationsFunctional recoveryBacterial insultPathwayProliferation markersProliferationAMP levelsCellsEpitheliumIntense sound