2023
Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification
Santos-Sacchi J, Bai J, Navaratnam D. Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification. Journal Of Neuroscience 2023, 43: 2460-2468. PMID: 36868859, PMCID: PMC10082455, DOI: 10.1523/jneurosci.2033-22.2023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MembraneCochleaGuinea PigsHair Cells, Auditory, OuterHearingMammalsUltrasonicsConceptsConformational switchingMammalian hearingMembrane motor proteinCochlear amplificationMotor protein prestinVoltage-sensor charge movementOuter hair cell electromotilityHair cell electromotilityProtein prestinMotor proteinsConformation switchingCharge movementPrestinPrestin activityCell membraneOHC electromotilityHair cell membraneElectromotilityTransmembrane voltageOrgan of CortiAmplificationMammalsMembrane capacitanceProtein
2007
Developmental Expression of the Outer Hair Cell Motor Prestin in the Mouse
Abe T, Kakehata S, Kitani R, Maruya S, Navaratnam D, Santos-Sacchi J, Shinkawa H. Developmental Expression of the Outer Hair Cell Motor Prestin in the Mouse. The Journal Of Membrane Biology 2007, 215: 49-56. PMID: 17415610, PMCID: PMC4154540, DOI: 10.1007/s00232-007-9004-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene Expression Regulation, DevelopmentalHair Cells, Auditory, OuterMiceMice, Inbred C57BLMolecular Motor ProteinsProtein ConformationProteinsConceptsLateral membranesOuter hair cellsMouse outer hair cellsMotor protein activitySteady-state levelsKnockout experimentsProtein activityDevelopmental expressionMembrane tensionGenetic modificationConformational fluctuationsCellular mechanismsMotor moleculesMolecular motorsOnset of hearingMorphological estimatesProtein densityEarly maturationQuantitative polymerase chain reactionHair cellsVpkCmDevelopmental dataCochlear amplificationMaturationFull maturation
2006
Hair Cells – Beyond the Transducer
Housley GD, Marcotti W, Navaratnam D, Yamoah EN. Hair Cells – Beyond the Transducer. The Journal Of Membrane Biology 2006, 209: 89. PMID: 16773496, DOI: 10.1007/s00232-005-0835-7.BooksMeSH KeywordsAnimalsHair Cells, Auditory, InnerHair Cells, Auditory, OuterMembrane PotentialsModels, BiologicalPotassium ChannelsReceptors, PurinergicSignal TransductionConceptsHair cell developmentHair cellsHair cell physiologySensory hair cellsOuter hair cell electromotilityMolecular physiologyHair cell electromotilityCell physiologyCell developmentPhysiological functionsMechanoelectrical transductionIon channelsBiophysical statusCell functionTransductionNeurotransmitter releaseHair cell functionPhysiologyCellsConsiderable arrayBroad dynamic rangeReview seriesMembrane conductanceElectromotilityPathway