2000
Molecular Determinants of Hair Cell Phenotypic Heterogeneity—Differential Expression of K Channel Genes
Navaratnam D, Oberholtzer J. Molecular Determinants of Hair Cell Phenotypic Heterogeneity—Differential Expression of K Channel Genes. 2000, 55-68. DOI: 10.1007/978-1-4615-4223-0_4.Peer-Reviewed Original ResearchChannel genesGene expressionAuditory receptor epitheliumAdditional gene productsK channel genesBK channel variantsLevel of transcriptionHair cellsPotassium channel genesRNA processingAlternative splicingSingle geneGene productsReceptor hair cellsReceptor epitheliumExpression patternsComplex patternsGenesMolecular determinantsChannel variantsLarge familyChick basilar papillaPhenotypic heterogeneityBasilar papillaChannel isoforms
1996
Proliferation in the auditory receptor epithelium mediated by a cyclic AMP–dependent signaling pathway
Navaratnam D, Su H, Scott S, Oberholtzer J. Proliferation in the auditory receptor epithelium mediated by a cyclic AMP–dependent signaling pathway. Nature Medicine 1996, 2: 1136-1139. PMID: 8837614, DOI: 10.1038/nm1096-1136.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthine8-Bromo Cyclic Adenosine MonophosphateAnimalsCarbazolesChickensCochleaColforsinCyclic AMPCyclic AMP-Dependent Protein KinasesDNA ReplicationEnzyme ActivationEnzyme InhibitorsGentamicinsHair Cells, AuditoryHearing Loss, SensorineuralIndolesIsoquinolinesOrgan Culture TechniquesPyrrolesRegenerationSignal TransductionSulfonamidesConceptsAuditory receptor epitheliumProtein kinase AHair cellsReplacement hair cellsReceptor epitheliumNew hair cellsProliferative responseRegenerative proliferationReceptor hair cellsKinase ASignaling pathwaysPKA inhibitorGentamicin damageCellular recoveryCyclic AMP levelsCell populationsFunctional recoveryBacterial insultPathwayProliferation markersProliferationAMP levelsCellsEpitheliumIntense sound