2024
Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs
Wang T, Ling A, Billings S, Hosseini D, Vaisbuch Y, Kim G, Atkinson P, Sayyid Z, Aaron K, Wagh D, Pham N, Scheibinger M, Zhou R, Ishiyama A, Moore L, Maria P, Blevins N, Jackler R, Alyono J, Kveton J, Navaratnam D, Heller S, Lopez I, Grillet N, Jan T, Cheng A. Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs. Nature Communications 2024, 15: 4833. PMID: 38844821, PMCID: PMC11156867, DOI: 10.1038/s41467-024-48491-y.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptome atlasInner ear hair cell lossNon-sensory cell typesCell regeneration in vivoVestibular schwannoma patientsTranscriptomic atlasHair cellsHair cell lossIGF-1 signalingHuman inner earMouse hair cellsCell trajectory analysisSchwannoma patientsDynamic gene expressionVestibular hair cellsPermanent hearingHair cell precursorsIGF-1Cell lossCell precursorsInner earRegenerative capacityMurine utriclesCell typesGene expression
2017
Prestin: Molecular Mechanisms Underlying Outer Hair Cell Electromotility
Santos-Sacchi J, Navaratnam D, Raphael R, Oliver D. Prestin: Molecular Mechanisms Underlying Outer Hair Cell Electromotility. Springer Handbook Of Auditory Research 2017, 62: 113-145. DOI: 10.1007/978-3-319-52073-5_5.Peer-Reviewed Original ResearchOuter hair cellsMammalian inner earOuter Hair Cell ElectromotilityHair cell electromotilitySLC26 familyMolecular mechanismsMembrane lipidsConformational changesMechanical feedback mechanismMolecular motorsTension sensitivityPrestinHair cellsVoltage-sensor charge movementAnion transportersReceptor potentialProteinMolecular conformational changesInner earStructural determinationIntracellular chlorideCharge movementTraffickingFeedback mechanismMechanism