2020
Impact of menthol on nicotine intake and preference in mice: Concentration, sex, and age differences
Bagdas D, Jackson A, Carper M, Chen RY, Akinola LS, Damaj MI. Impact of menthol on nicotine intake and preference in mice: Concentration, sex, and age differences. Neuropharmacology 2020, 179: 108274. PMID: 32827516, PMCID: PMC7572603, DOI: 10.1016/j.neuropharm.2020.108274.Peer-Reviewed Original ResearchConceptsOral nicotine consumptionEffect of mentholImpact of mentholNicotine consumptionFemale miceNicotine intakeΑ7 nicotinic acetylcholine receptorMenthol concentrationNicotine solutionHigher nicotine intakeAdolescent female miceMale C57BL/6J miceTwo-bottle choice paradigmWild-type miceNicotinic acetylcholine receptorsConcentration-dependent mannerOral nicotineC57BL/6J miceKO miceMale miceType miceMouse modelAcetylcholine receptorsHigh menthol concentrationAdult counterpartsAging protects rat cortical slices against to oxygen-glucose deprivation induced damage
Gul Z, Demircan C, Bagdas D, Buyukuysal RL. Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage. International Journal Of Neuroscience 2020, 130: 1183-1191. PMID: 32064981, DOI: 10.1080/00207454.2020.1730830.Peer-Reviewed Original ResearchConceptsOxygen-glucose deprivationCortical slicesRat cortical slicesMale Sprague-DawleyAged male ratsOGD mediumS100B levelsLactate dehydrogenase leakageCerebral cortexControl conditionYoung slicesMale ratsSprague-DawleyAged animalsBrain regionsBrain tissueReoxygenationMore increaseStaining intensityDehydrogenase leakagePossible involvementMinutes incubationRatsPresent studySimilar decline
2019
Adolescent but not adult ethanol binge drinking modulates ethanol behavioral effects in mice later in life
Younis R, Wolstenholme J, Bagdas D, Bettinger J, Miles M, Damaj M. Adolescent but not adult ethanol binge drinking modulates ethanol behavioral effects in mice later in life. Pharmacology Biochemistry And Behavior 2019, 184: 172740. PMID: 31326461, PMCID: PMC6697373, DOI: 10.1016/j.pbb.2019.172740.Peer-Reviewed Original ResearchConceptsEthanol intakeEthanol drinkingEthanol's behavioral effectsEarly exposureAdolescent ethanol exposureEnhanced ethanol intakeAlcohol use disorderAnxiety-related behaviorAdolescence altersDrug-taking behaviorAlcohol intakeC57BL/6J miceEthanol exposureWithdrawal stateLong-term effectsNeurochemical mechanismsMouse modelBinge drinkingAdult miceUse disordersSerious illnessAbuse liabilityDrinking paradigmAdult exposureAdolescent population