2016
Chlorogenic Acid Enhances Abdominal Skin Flap Survival Based on Epigastric Artery in Nondiabetic and Diabetic Rats
Bagdas D, Etoz B, Gul Z, Ozyigit M, Cinkilic N, Inan S, Buyukcoskun N, Ozluk K, Gurun M. Chlorogenic Acid Enhances Abdominal Skin Flap Survival Based on Epigastric Artery in Nondiabetic and Diabetic Rats. Annals Of Plastic Surgery 2016, 77: e21-e25. PMID: 25356637, DOI: 10.1097/sap.0000000000000313.Peer-Reviewed Original ResearchConceptsFlap survivalDiabetic ratsEpigastric arteryFlap tissueMg/0.5 mLEffects of CGASkin flap survivalPostoperative day 7Abdominal skin flapSkin flap modelGreater flap survivalChlorogenic acidCGA treatmentFemoral arteryLocal injectionAntioxidant activitySingle arteryCapillary densityDismutase levelsMalondialdehyde levelsSkin flapsDay 7ArteryFlap modelRats
2015
In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile
Bagdas D, Etoz B, Gul Z, Ziyanok S, Inan S, Turacozen O, Gul N, Topal A, Cinkilic N, Tas S, Ozyigit M, Gurun M. In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile. Food And Chemical Toxicology 2015, 81: 54-61. PMID: 25846499, DOI: 10.1016/j.fct.2015.04.001.Peer-Reviewed Original ResearchConceptsSide effectsOxidative stressStreptozotocin-induced diabetic ratsChronic antioxidant treatmentEndogenous antioxidant defense systemNitric oxide levelsWound healingBlood glucose levelsSystemic antioxidant therapyDays of treatmentPossible side effectsDiabetic wound repairLipid peroxidation levelsChlorogenic acidAcid therapyDiabetic ratsHistopathological examinationPossible pro-oxidative effectsPro-oxidative effectsAntioxidant intakePivotal organAntioxidant therapyDiabetic conditionsAntioxidant balanceGlucose levels
2014
Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing
Bagdas D, Gul N, Topal A, Tas S, Ozyigit M, Cinkilic N, Gul Z, Etoz B, Ziyanok S, Inan S, Turacozen O, Gurun M. Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing. Naunyn-Schmiedeberg's Archives Of Pharmacology 2014, 387: 1101-1116. PMID: 25129377, DOI: 10.1007/s00210-014-1034-9.Peer-Reviewed Original ResearchConceptsSide effectsWound healingHigh doseBone marrowEffects of CGAAnti-inflammatory effectsDietary chlorogenic acidNitric oxide levelsMatrix metalloproteinase-9Oxidative stress markersPossible side effectsDose-dependent mannerChlorogenic acidCGA supplementationPharmacologic overviewFree radical scavengerAcid therapyCGA treatmentLeukocyte infiltrationPivotal organImmunohistochemical examinationRat bone marrowMetalloproteinase-9Oxide levelsStress markers