2022
Chronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine’s effects in adolescent rats
Bagdas D, Harris L, Addy N. Chronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine’s effects in adolescent rats. Neuroscience Letters 2022, 793: 137008. PMID: 36476758, PMCID: PMC9948648, DOI: 10.1016/j.neulet.2022.137008.Peer-Reviewed Original ResearchConceptsTaste responsesNicotine concentrationsNicotine exposureNicotine withdrawalNicotine effectsAdolescent ratsChronic exposureOral nicotine exposureTaste reactivityAversive tasteChronic nicotine exposureDevelopment of toleranceLow nicotine concentrationsE-cigarette useE-cigarette flavoringsHigher nicotine concentrationsNicotine abstinenceNicotine useNaïve animalsChronic effectsNicotineRatsAversive responsesDifferent nicotine concentrationsWithdrawal
2021
Evaluation of Flavor Effects on Oral Nicotine Liking and/or Disliking Using the Taste Reactivity Test in Rats
Bagdas D, Rupprecht LE, Nunes EJ, Schillinger E, Immanuel JJ, Addy NA. Evaluation of Flavor Effects on Oral Nicotine Liking and/or Disliking Using the Taste Reactivity Test in Rats. Nicotine & Tobacco Research 2021, 24: 753-760. PMID: 34918123, PMCID: PMC8962681, DOI: 10.1093/ntr/ntab241.Peer-Reviewed Original ResearchConceptsTaste reactivity testOrosensory experienceAversive responsesAbuse liabilityAversive valueAversive reactionsHedonic responsesNicotine rewardTaking behaviorIntraoral cathetersImpact of mentholReactivity testOlfactory cuesOrofacial movementsDislikingLikingNicotine responseTaste stimuliSex-dependent mannerOral nicotineNicotine inducesNicotineCuesIngestive responsesExperience