2022
Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein
Toma W, Paris J, Warncke U, Nass S, Caillaud M, McKiver B, Ondo O, Bagdas D, Bigbee J, Knapp P, Hauser K, Damaj M. Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein. Experimental Neurology 2022, 358: 114226. PMID: 36096180, PMCID: PMC10053560, DOI: 10.1016/j.expneurol.2022.114226.Peer-Reviewed Original ResearchConceptsSensory neuropathyFemale miceHIV-1Tat expressionSensory nerve action potentialsIntraepidermal nerve fiber densityChronic HIV-1Persistent sensory changesPain-like behaviorsPeripheral sensory neuropathySevere chronic painDevelopment of neuropathyNerve fiber densityLumbar spinal cordDevelopment of hypersensitivityNerve action potentialsPrevious preclinical studiesDorsal root gangliaTNF-α expressionPPAR-α gene expressionTat regulatory proteinRole of TatHIV-1 TatSex differencesAllodynic responses
2020
Impact of menthol on nicotine intake and preference in mice: Concentration, sex, and age differences
Bagdas D, Jackson A, Carper M, Chen RY, Akinola LS, Damaj MI. Impact of menthol on nicotine intake and preference in mice: Concentration, sex, and age differences. Neuropharmacology 2020, 179: 108274. PMID: 32827516, PMCID: PMC7572603, DOI: 10.1016/j.neuropharm.2020.108274.Peer-Reviewed Original ResearchConceptsOral nicotine consumptionEffect of mentholImpact of mentholNicotine consumptionFemale miceNicotine intakeΑ7 nicotinic acetylcholine receptorMenthol concentrationNicotine solutionHigher nicotine intakeAdolescent female miceMale C57BL/6J miceTwo-bottle choice paradigmWild-type miceNicotinic acetylcholine receptorsConcentration-dependent mannerOral nicotineC57BL/6J miceKO miceMale miceType miceMouse modelAcetylcholine receptorsHigh menthol concentrationAdult counterparts
2019
Pharmacological mechanisms of alcohol analgesic-like properties in mouse models of acute and chronic pain
Neddenriep B, Bagdas D, Contreras K, Ditre J, Wolstenholme J, Miles M, Damaj M. Pharmacological mechanisms of alcohol analgesic-like properties in mouse models of acute and chronic pain. Neuropharmacology 2019, 160: 107793. PMID: 31562845, PMCID: PMC6924270, DOI: 10.1016/j.neuropharm.2019.107793.Peer-Reviewed Original ResearchConceptsAnalgesic-like propertiesComplete Freund's adjuvantAnti-nociceptive propertiesChronic painNeuropathic painChronic constriction injury modelAlcohol useMu-opioid systemOral ethanol administrationPain-like statePeripheral neuropathic painNeuropathic pain modelKappa-selective antagonistAcute alcohol useAnalgesic-like effectsDose-dependent reversalMechanical hypersensitivityAnalgesic effectNerve injuryPain modelAcute modelOpioid systemAcute alcoholFreund's adjuvantChronic useAssessing nicotine dependence using an oral nicotine free-choice paradigm in mice
Bagdas D, Diester C, Riley J, Carper M, Alkhlaif Y, AlOmari D, Alayoubi H, Poklis J, Damaj M. Assessing nicotine dependence using an oral nicotine free-choice paradigm in mice. Neuropharmacology 2019, 157: 107669. PMID: 31220484, PMCID: PMC6697382, DOI: 10.1016/j.neuropharm.2019.107669.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AddictiveChoice BehaviorDose-Response Relationship, DrugDrug InteractionsFemaleMaleMiceMice, KnockoutNicotineNucleus AccumbensQuinineReceptors, NicotinicSelf AdministrationSex CharacteristicsSubstance Withdrawal SyndromeTobacco Use DisorderTyrosine 3-MonooxygenaseVareniclineConceptsAddictive-like propertiesNicotine intakeOral nicotine consumptionNicotine consumptionFree-choice paradigmNicotine solutionΑ6 KO miceTwo-bottle free-choice paradigmTyrosine hydroxylase levelsNicotinic acetylcholine receptor subunitsPartial agonist vareniclineOral nicotine intakeAbsence of nicotineAcetylcholine receptor subunitsΑ5 nAChRAdult C57BL/6JNicotine withdrawalKO miceFemale miceAgonist vareniclineDBA/2J miceHydroxylase levelsNicotine dependenceBinge drinkingObserved sex differencesImpact of Menthol on Oral Nicotine Consumption in Female and Male Sprague Dawley Rats
Bagdas D, Cam B, Gul Z, Scott MM, Tyndale RF, Buyukuysal RL, Damaj MI, Gurun MS. Impact of Menthol on Oral Nicotine Consumption in Female and Male Sprague Dawley Rats. Nicotine & Tobacco Research 2019, 22: 196-203. PMID: 30753589, DOI: 10.1093/ntr/ntz019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChoice BehaviorFemaleFlavoring AgentsMaleMentholNicotineRatsRats, Sprague-DawleySex CharacteristicsTasteConceptsOral nicotine consumptionImpact of mentholNicotine intakeFemale ratsMale ratsNicotine consumptionSprague-DawleyNicotine levelsTwo-bottle free-choice paradigmMale Sprague-DawleyTotal fluid intakeAdult Sprague-DawleyBody weight changesNicotine delivery systemsOral mentholNicotine groupFluid intakeDissolvable tobacco productsSmokeless tobaccoRatsTobacco productsNicotineIntakeNicotine solutionWeight change