2020
Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype
Contreras KM, Caillaud M, Neddenriep B, Bagdas D, Roberts JL, Ulker E, White AB, Aboulhosn R, Toma W, Khalefa T, Adel A, Mann JA, Damaj MI. Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype. Behavioural Brain Research 2020, 399: 113009. PMID: 33181181, PMCID: PMC8961431, DOI: 10.1016/j.bbr.2020.113009.Peer-Reviewed Original ResearchConceptsNeuropathic pain modelChronic constriction injuryMechanical withdrawal thresholdPain modelStrains of miceWithdrawal thresholdDBA/2J miceVoluntary wheelChronic neuropathic pain modelPaclitaxel-treated miceVehicle-treated miceUnilateral intraplantar injectionLower mechanical thresholdsChronic pain reportQuality of lifeChemotherapy agent paclitaxelImpact of sexDifferent mouse strainsCCI miceCCI surgeryConstriction injuryIntraplantar injectionSham surgeryMale C57BL/6JNovel analgesics
2018
Reduced intraepidermal nerve fibre density, glial activation, and sensory changes in HIV type-1 Tat-expressing female mice
Wodarski R, Bagdas D, Paris J, Pheby T, Toma W, Xu R, Damaj M, Knapp P, Rice A, Hauser K. Reduced intraepidermal nerve fibre density, glial activation, and sensory changes in HIV type-1 Tat-expressing female mice. PAIN Reports 2018, 3: e654. PMID: 29922746, PMCID: PMC5999412, DOI: 10.1097/pr9.0000000000000654.Peer-Reviewed Original ResearchIntraepidermal nerve fiber densityDorsal root gangliaNerve fiber densitySensory neuropathyTAT inductionHIV infectionFiber densityFemale miceSpinal cordHIV type 1 (HIV-1) TatIba-1-positive cellsLumbar dorsal root gangliaGlial fibrillary acidic protein immunoreactivityGlial fibrillary acidic protein promoterClinical HIV infectionPaw withdrawal thresholdPaw withdrawal latencyChronic pain statesSpontaneous motor activityImmune cell activationAcidic protein promoterPainful HIVGlial activationPaw withdrawalWithdrawal threshold