2020
Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype
Contreras KM, Caillaud M, Neddenriep B, Bagdas D, Roberts JL, Ulker E, White AB, Aboulhosn R, Toma W, Khalefa T, Adel A, Mann JA, Damaj MI. Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype. Behavioural Brain Research 2020, 399: 113009. PMID: 33181181, PMCID: PMC8961431, DOI: 10.1016/j.bbr.2020.113009.Peer-Reviewed Original ResearchConceptsNeuropathic pain modelChronic constriction injuryMechanical withdrawal thresholdPain modelStrains of miceWithdrawal thresholdDBA/2J miceVoluntary wheelChronic neuropathic pain modelPaclitaxel-treated miceVehicle-treated miceUnilateral intraplantar injectionLower mechanical thresholdsChronic pain reportQuality of lifeChemotherapy agent paclitaxelImpact of sexDifferent mouse strainsCCI miceCCI surgeryConstriction injuryIntraplantar injectionSham surgeryMale C57BL/6JNovel analgesics
2019
Chapter 33 Targeting Nicotinic Acetylcholine Receptors for the Treatment of Pain
Bagdas D, Kyte S, Toma W, Gurun M, Damaj M. Chapter 33 Targeting Nicotinic Acetylcholine Receptors for the Treatment of Pain. 2019, 259-266. DOI: 10.1016/b978-0-12-813035-3.00033-2.Peer-Reviewed Original ResearchNicotinic acetylcholine receptorsAcetylcholine receptorsNAChR ligandsTreatment of painRecent animal studiesNarrow therapeutic windowPeripheral nervous systemPositive allosteric modulatorsAnalgesic efficacyPain managementChronic painNeuropathic conditionsImmune cellsNovel analgesicsTherapeutic windowAnimal modelsAnimal studiesHuman studiesNervous systemNicotinic agentsAllosteric modulatorsTherapeutic potentialPainPromising agentSilent agonist
2018
Effect of nicotine and alpha‐7 nicotinic modulators on visceral pain‐induced conditioned place aversion in mice
Bagdas D, Meade J, Alkhlaif Y, Muldoon P, Carroll F, Damaj M. Effect of nicotine and alpha‐7 nicotinic modulators on visceral pain‐induced conditioned place aversion in mice. European Journal Of Pain 2018, 22: 1419-1427. PMID: 29633429, PMCID: PMC6179949, DOI: 10.1002/ejp.1231.Peer-Reviewed Original ResearchEffects of nicotineVisceral painΑ7 nAChRsPlace aversionIntraperitoneal acetic acid administrationAcetic acid administrationAllosteric modulationΑ7-nAChR activationDose-dependent reductionNAChR agonist nicotineNeurobiology of painDose-dependent mannerAntinociceptive effectAcid administrationPeripheral mechanismsAntinociceptive propertiesNAChR activationNicotine effectsNicotinic antagonistsNovel analgesicsSystemic administrationReceptor modulatorsAgonist nicotineNAChR agonistsPain
2014
Nicotinic Receptors as Targets for Novel Analgesics and Anti-inflammatory Drugs
Damaj M, Freitas K, Bagdas D, Flood P. Nicotinic Receptors as Targets for Novel Analgesics and Anti-inflammatory Drugs. The Receptors 2014, 26: 239-254. DOI: 10.1007/978-1-4939-1167-7_12.Peer-Reviewed Original ResearchPositive allosteric modulatorsNicotinic receptorsNovel analgesicsTherapeutic windowChronic inflammatory pain conditionsAllosteric modulatorsInflammatory pain conditionsRecent animal studiesNarrow therapeutic windowPeripheral nervous systemAnti-inflammatory drugsAnalgesic efficacyPain controlPain conditionsΑ7 agonistsImmune cellsSelective α4β2Animal modelsHuman studiesAnimal studiesNervous systemNicotinic agentsTherapeutic potentialAgonistsAnalgesics