2019
A silent agonist of α7 nicotinic acetylcholine receptors modulates inflammation ex vivo and attenuates EAE
Godin J, Roy P, Quadri M, Bagdas D, Toma W, Narendrula-Kotha R, Kishta O, Damaj M, Horenstein N, Papke R, Simard A. A silent agonist of α7 nicotinic acetylcholine receptors modulates inflammation ex vivo and attenuates EAE. Brain Behavior And Immunity 2019, 87: 286-300. PMID: 31874200, PMCID: PMC7604877, DOI: 10.1016/j.bbi.2019.12.014.Peer-Reviewed Original ResearchConceptsNicotinic acetylcholine receptorsSilent agonistInflammatory painCytokine productionΑ7 nAChRsAnimal modelsAcetylcholine receptorsΑ7 nicotinic acetylcholine receptorNon-neuronal nAChRsExperimental autoimmune encephalomyelitisChronic inflammatory painAnti-inflammatory compoundsInflammation ex vivoChannel openingAutoimmune encephalomyelitisAntagonist mecamylamineMultiple sclerosisInflammatory disordersModulates inflammationMacrophage numbersDisease manifestationsNervous systemReceptor desensitizationInflammationAgonistsChapter 33 Targeting Nicotinic Acetylcholine Receptors for the Treatment of Pain
Bagdas D, Kyte S, Toma W, Gurun M, Damaj M. Chapter 33 Targeting Nicotinic Acetylcholine Receptors for the Treatment of Pain. 2019, 259-266. DOI: 10.1016/b978-0-12-813035-3.00033-2.Peer-Reviewed Original ResearchNicotinic acetylcholine receptorsAcetylcholine receptorsNAChR ligandsTreatment of painRecent animal studiesNarrow therapeutic windowPeripheral nervous systemPositive allosteric modulatorsAnalgesic efficacyPain managementChronic painNeuropathic conditionsImmune cellsNovel analgesicsTherapeutic windowAnimal modelsAnimal studiesHuman studiesNervous systemNicotinic agentsAllosteric modulatorsTherapeutic potentialPainPromising agentSilent agonist
2014
Nicotinic Receptors as Targets for Novel Analgesics and Anti-inflammatory Drugs
Damaj M, Freitas K, Bagdas D, Flood P. Nicotinic Receptors as Targets for Novel Analgesics and Anti-inflammatory Drugs. The Receptors 2014, 26: 239-254. DOI: 10.1007/978-1-4939-1167-7_12.Peer-Reviewed Original ResearchPositive allosteric modulatorsNicotinic receptorsNovel analgesicsTherapeutic windowChronic inflammatory pain conditionsAllosteric modulatorsInflammatory pain conditionsRecent animal studiesNarrow therapeutic windowPeripheral nervous systemAnti-inflammatory drugsAnalgesic efficacyPain controlPain conditionsΑ7 agonistsImmune cellsSelective α4β2Animal modelsHuman studiesAnimal studiesNervous systemNicotinic agentsTherapeutic potentialAgonistsAnalgesics
2012
Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain
Bagdas D, Cinkilic N, Ozboluk H, Ozyigit M, Gurun M. Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain. Journal Of Natural Medicines 2012, 67: 698-704. PMID: 23203628, DOI: 10.1007/s11418-012-0726-z.Peer-Reviewed Original ResearchConceptsChronic constrictive nerve injuryNeuropathic painAntihyperalgesic activityPeripheral neuropathic pain modelExperimental neuropathic painNeuropathic pain modelRota-rod testNovel potential therapeutic optionPotential therapeutic optionStrong therapeutic effectLatency of ratsChlorogenic acidAntihyperalgesic effectMechanical hyperalgesiaNerve injuryPain modelChronic administrationInflammatory cascadeTherapeutic optionsHistopathological changesInflammatory processTherapeutic effectAnalgesic activityPainNervous system