2022
Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein
Toma W, Paris J, Warncke U, Nass S, Caillaud M, McKiver B, Ondo O, Bagdas D, Bigbee J, Knapp P, Hauser K, Damaj M. Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein. Experimental Neurology 2022, 358: 114226. PMID: 36096180, PMCID: PMC10053560, DOI: 10.1016/j.expneurol.2022.114226.Peer-Reviewed Original ResearchConceptsSensory neuropathyFemale miceHIV-1Tat expressionSensory nerve action potentialsIntraepidermal nerve fiber densityChronic HIV-1Persistent sensory changesPain-like behaviorsPeripheral sensory neuropathySevere chronic painDevelopment of neuropathyNerve fiber densityLumbar spinal cordDevelopment of hypersensitivityNerve action potentialsPrevious preclinical studiesDorsal root gangliaTNF-α expressionPPAR-α gene expressionTat regulatory proteinRole of TatHIV-1 TatSex differencesAllodynic responses
2018
Reduced intraepidermal nerve fibre density, glial activation, and sensory changes in HIV type-1 Tat-expressing female mice
Wodarski R, Bagdas D, Paris J, Pheby T, Toma W, Xu R, Damaj M, Knapp P, Rice A, Hauser K. Reduced intraepidermal nerve fibre density, glial activation, and sensory changes in HIV type-1 Tat-expressing female mice. PAIN Reports 2018, 3: e654. PMID: 29922746, PMCID: PMC5999412, DOI: 10.1097/pr9.0000000000000654.Peer-Reviewed Original ResearchIntraepidermal nerve fiber densityDorsal root gangliaNerve fiber densitySensory neuropathyTAT inductionHIV infectionFiber densityFemale miceSpinal cordHIV type 1 (HIV-1) TatIba-1-positive cellsLumbar dorsal root gangliaGlial fibrillary acidic protein immunoreactivityGlial fibrillary acidic protein promoterClinical HIV infectionPaw withdrawal thresholdPaw withdrawal latencyChronic pain statesSpontaneous motor activityImmune cell activationAcidic protein promoterPainful HIVGlial activationPaw withdrawalWithdrawal threshold