2020
Effect of High Fructose Corn Sirup on Pancreatic Ductal Adenocarcinoma Induced by Dimethyl Benzantracene (DMBA) in Rats
Ozcan-Sınır G, Inan S, Suna S, Tamer CE, Akgül MB, Bagdas D, Sonmez G, Evrensel T, Kaya E, Sarandol E, Dündar HZ, Tarım OF, Ercan I, Sıgırlı D, Incedayı B, Copur OU. Effect of High Fructose Corn Sirup on Pancreatic Ductal Adenocarcinoma Induced by Dimethyl Benzantracene (DMBA) in Rats. Nutrition And Cancer 2020, 73: 339-349. PMID: 32475178, DOI: 10.1080/01635581.2020.1770811.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaMale Sprague-Dawley ratsDevelopment of PDACSprague-Dawley ratsConsumption of sugarHistopathologic findingsPancreatic cancerDawley ratsDuctal adenocarcinomaRat modelGlucose levelsChow consumptionBody weightHistologic specimensDifferentiated typeDimethyl benzanthraceneDaily intakeRatsEntire groupTissue processing protocolChowTumor formationSignificant differencesFeeding periodGroup
2015
In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile
Bagdas D, Etoz B, Gul Z, Ziyanok S, Inan S, Turacozen O, Gul N, Topal A, Cinkilic N, Tas S, Ozyigit M, Gurun M. In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile. Food And Chemical Toxicology 2015, 81: 54-61. PMID: 25846499, DOI: 10.1016/j.fct.2015.04.001.Peer-Reviewed Original ResearchConceptsSide effectsOxidative stressStreptozotocin-induced diabetic ratsChronic antioxidant treatmentEndogenous antioxidant defense systemNitric oxide levelsWound healingBlood glucose levelsSystemic antioxidant therapyDays of treatmentPossible side effectsDiabetic wound repairLipid peroxidation levelsChlorogenic acidAcid therapyDiabetic ratsHistopathological examinationPossible pro-oxidative effectsPro-oxidative effectsAntioxidant intakePivotal organAntioxidant therapyDiabetic conditionsAntioxidant balanceGlucose levels