2024
Design and implementation of a Type-2 hybrid, prospective randomized trial of opioid agonist therapies integration into primary care clinics in Ukraine
Machavariani E, Dumchev K, Pykalo I, Filippovych M, Ivasiy R, Esserman D, Madden L, Bromberg D, Haddad M, Morozova O, Ahmad B, Gómez D, Farnum S, Dvoriak S, Altice F. Design and implementation of a Type-2 hybrid, prospective randomized trial of opioid agonist therapies integration into primary care clinics in Ukraine. Contemporary Clinical Trials 2024, 146: 107690. PMID: 39265780, PMCID: PMC11531372, DOI: 10.1016/j.cct.2024.107690.Peer-Reviewed Original ResearchPrimary care centersQuality health indicatorsNon-communicable diseasesSpecialty treatment centersOpioid agonist therapyImplementation of integrated carePay-for-performance incentivesPrimary care clinicsPrimary care settingSelf-reported prevalencePay-for-performancePrevalence of medical comorbiditiesParticipants self-reportedEffective evidence-based treatmentsHealth of PWIDEvidence-based treatmentsIntegrated careCare clinicsImplementation outcomesImplementation trialCare settingsElectronic chart reviewHigh-burden countriesSpecialty servicesHIV prevalenceAssessing readiness to use electronic health record data for outcome ascertainment in clinical trials – A case study
Esserman D, Greene E, Latham N, Kane M, Lu C, Peduzzi P, Gill T, Ganz D. Assessing readiness to use electronic health record data for outcome ascertainment in clinical trials – A case study. Contemporary Clinical Trials 2024, 142: 107572. PMID: 38740298, DOI: 10.1016/j.cct.2024.107572.Peer-Reviewed Original ResearchElectronic health record dataElectronic health recordsOutcome ascertainmentDevelop Confidence in EldersElectronic health record platformsClinical sitesPrimary care practicesHealth record dataMulti-site trialMulti-site clinical trialCare practicesHealth recordsAssess readinessAcute clinical outcomesHealthcare systemRecord dataClinical trialsReduce injuriesData qualityData comprehensionChecklistStudy dataClinical trial sitesVariable data qualityAscertainmentA Bayesian platform trial design with hybrid control based on multisource exchangeability modelling
Wei W, Blaha O, Esserman D, Zelterman D, Kane M, Liu R, Lin J. A Bayesian platform trial design with hybrid control based on multisource exchangeability modelling. Statistics In Medicine 2024, 43: 2439-2451. PMID: 38594809, PMCID: PMC11325877, DOI: 10.1002/sim.10077.Peer-Reviewed Original ResearchValidation of a Rule-Based ICD-10-CM Algorithm to Detect Fall Injuries in Medicare Data
Ganz D, Esserman D, Latham N, Kane M, Min L, Gill T, Reuben D, Peduzzi P, Greene E. Validation of a Rule-Based ICD-10-CM Algorithm to Detect Fall Injuries in Medicare Data. The Journals Of Gerontology Series A 2024, 79: glae096. PMID: 38566617, PMCID: PMC11167485, DOI: 10.1093/gerona/glae096.Peer-Reviewed Original ResearchFee-for-serviceFall injuriesMedicare AdvantageMedicare dataTrial armsHealthcare systemDevelop Confidence in EldersArea under the receiver operating characteristic curveMedicare fee-for-serviceStratified resultsMedicareReduce injuriesMedical attentionObservational studyStrideReceiver operating characteristic curveCalendar monthMA dataInjuryData sourcesHealthcareArmReference standardTrialsWindow sizeAssociation between diet quality and ovarian cancer risk and survival
Cao A, Esserman D, Cartmel B, Irwin M, Ferrucci L. Association between diet quality and ovarian cancer risk and survival. Journal Of The National Cancer Institute 2024, 116: 1095-1104. PMID: 38400738, PMCID: PMC11223874, DOI: 10.1093/jnci/djae040.Peer-Reviewed Original ResearchOvarian cancer riskAll-cause mortalityAssociated with lower all-cause mortalityDiet qualityCancer riskOvarian cancer diagnosisAssociated with ovarian cancer riskPre-diagnosisProspective NIH-AARP DietHealthy Eating Index-2015Cancer diagnosisNIH-AARP DietStop Hypertension scoreCancer registry dataEpithelial ovarian cancerMediterranean diet scoreFood frequency questionnaireCox proportional hazards regressionOvarian cancerProportional hazards regressionHEI-2015Health StudyHypertension scoreDiet scoreFrequency questionnaireAssociation Between Rental Assistance Programs and Undiagnosed Diabetes Among U.S
Gonzalez-Lopez C, Fenelon A, Lipska K, Denary W, Schlesinger P, Esserman D, Keene D. Association Between Rental Assistance Programs and Undiagnosed Diabetes Among U.S. Journal Of General Internal Medicine 2024, 39: 1625-1631. PMID: 38351417, PMCID: PMC11255160, DOI: 10.1007/s11606-024-08673-2.Peer-Reviewed Original ResearchOdds of undiagnosed diabetesRental assistance programsRental assistanceUndiagnosed diabetesAssistance programsHousing programsNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyRates of undiagnosed diabetesAssociated with lower oddsNutrition Examination SurveyAssociated with decreased oddsAssisted housingLogistic regression modelsHousing qualityHealthcare accessPoverty ratioExamination SurveyDiabetes screeningQuasi-experimental approachLower oddsHealth dataAssisted groupAssisted participantsEducation levelBayesian semi-parametric inference for clustered recurrent events with zero inflation and a terminal event
Tian X, Ciarleglio M, Cai J, Greene E, Esserman D, Li F, Zhao Y. Bayesian semi-parametric inference for clustered recurrent events with zero inflation and a terminal event. Journal Of The Royal Statistical Society Series C (Applied Statistics) 2024, 73: 598-620. PMID: 39072299, PMCID: PMC11271983, DOI: 10.1093/jrsssc/qlae003.Peer-Reviewed Original ResearchSemi-parametric inferenceRecurrent eventsAccelerated failure time modelFailure time modelEfficient sampling algorithmFrailty distributionDirichlet processPosterior inferenceSampling algorithmTime modelTerminal eventSurvival processesComplex data structuresDirichletInferenceData structureFall injury preventionAlgorithmHierarchical Bayesian modeling of heterogeneous outcome variance in cluster randomized trials
Tong G, Tong J, Jiang Y, Esserman D, Harhay M, Warren J. Hierarchical Bayesian modeling of heterogeneous outcome variance in cluster randomized trials. Clinical Trials 2024, 21: 451-460. PMID: 38197388, PMCID: PMC11233424, DOI: 10.1177/17407745231222018.Peer-Reviewed Original Research
2023
A compressed large language model embedding dataset of ICD 10 CM descriptions
Kane M, King C, Esserman D, Latham N, Greene E, Ganz D. A compressed large language model embedding dataset of ICD 10 CM descriptions. BMC Bioinformatics 2023, 24: 482. PMID: 38105180, PMCID: PMC10726612, DOI: 10.1186/s12859-023-05597-2.Peer-Reviewed Original ResearchThe design and baseline characteristics for the HOPE Consortium Trial to reduce pain and opioid use in hemodialysis
Dember L, Hsu J, Bernardo L, Cavanaugh K, Charytan D, Crowley S, Cukor D, Doorenbos A, Edwards D, Esserman D, Fischer M, Jhamb M, Joffe S, Johansen K, Kalim S, Keefe F, Kimmel P, Krebs E, Kuzla N, Mehrotra R, Mishra P, Pellegrino B, Steel J, Unruh M, White D, Yabes J, Becker W, Consortium F. The design and baseline characteristics for the HOPE Consortium Trial to reduce pain and opioid use in hemodialysis. Contemporary Clinical Trials 2023, 136: 107409. PMID: 38086444, PMCID: PMC10922728, DOI: 10.1016/j.cct.2023.107409.Peer-Reviewed Original ResearchGroup sequential two‐stage preference designs
Liu R, Li F, Esserman D, Ryan M. Group sequential two‐stage preference designs. Statistics In Medicine 2023, 43: 315-341. PMID: 38010193, DOI: 10.1002/sim.9962.Peer-Reviewed Original ResearchAlcohol Use and Sustained Virologic Response to Hepatitis C Virus Direct-Acting Antiviral Therapy
Cartwright E, Pierret C, Minassian C, Esserman D, Tate J, Goetz M, Bhattacharya D, Fiellin D, Justice A, Re V, Rentsch C. Alcohol Use and Sustained Virologic Response to Hepatitis C Virus Direct-Acting Antiviral Therapy. JAMA Network Open 2023, 6: e2335715. PMID: 37751206, PMCID: PMC10523171, DOI: 10.1001/jamanetworkopen.2023.35715.Peer-Reviewed Original ResearchConceptsSustained virologic responseAlcohol use disorderHigh-risk consumptionHistory of AUDLow-risk consumptionDAA therapyAlcohol use categoriesAlcohol useVirologic responseCohort studyAntiviral therapyOdds ratioChronic hepatitis C virus (HCV) infectionAlcohol Use Disorders Identification Test-Consumption (AUDIT-C) questionnaireHepatitis C virus infectionVeterans AffairsActing antiviral (DAA) therapyDAA treatment initiationHCV elimination goalsUndetectable HCV RNAC virus infectionFibrosis-4 scoreRetrospective cohort studyMultivariable logistic regressionTenth Revision diagnosisStructural Racism, Lifestyle Behaviors, and Obesity-related Cancers among Black and Hispanic/Latino Adults in the United States: A Narrative Review.
Pichardo M, Ferrucci L, Molina Y, Esserman D, Irwin M. Structural Racism, Lifestyle Behaviors, and Obesity-related Cancers among Black and Hispanic/Latino Adults in the United States: A Narrative Review. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1498-1507. PMID: 37650844, PMCID: PMC10872641, DOI: 10.1158/1055-9965.epi-22-1147.Peer-Reviewed Original ResearchConceptsHispanic/Latino adultsObesity-related cancersLifestyle behaviorsLatino adultsLifestyle guidelinesCancer preventionPoor lifestyle behaviorsU.S. Hispanic/Latino adultsHealthful lifestyle behaviorsCause of deathHealthy lifestyle choicesChronic diseasesCardiovascular diseaseCommon causeCancer riskNarrative reviewBlack adultsDisproportionate burdenObesityCancerAdultsLifestyle choicesDiseasePreventionDeathCompeting risks regression for clustered survival data via the marginal additive subdistribution hazards model
Chen X, Esserman D, Li F. Competing risks regression for clustered survival data via the marginal additive subdistribution hazards model. Statistica Neerlandica 2023, 78: 281-301. DOI: 10.1111/stan.12317.Peer-Reviewed Original ResearchSandwich variance estimatorCorrelated failure time dataVariance estimatorUnknown dependency structureFailure time dataAdditive hazards modelFinite samplesEquation approachCensoring timeCorrelation structureAdditive structureDependent censoringFit testSimulation studyEvent of interestDependency structureFailure timeEstimatorSubdistribution hazardRegression coefficientsIncidence functionCumulative incidence functionSubdistribution hazard modelTime dataOverall modelDeveloping and testing a COVID-19 vaccination acceptance intervention: A pragmatic trial comparing vaccine acceptance intervention vs usual care – Rationale, methods, and implementation
Pyne J, Seal K, Manuel J, DeRonne B, Oliver K, Bertenthal D, Esserman D, Purcell N, Petrakis B, Elwy A. Developing and testing a COVID-19 vaccination acceptance intervention: A pragmatic trial comparing vaccine acceptance intervention vs usual care – Rationale, methods, and implementation. Contemporary Clinical Trials 2023, 133: 107325. PMID: 37652356, DOI: 10.1016/j.cct.2023.107325.Peer-Reviewed Original ResearchVaccination ratesHealthcare providersAcceptance interventionsCOVID-19 vaccine acceptanceOne-year clusterImplementation-effectiveness trialVaccine information sourcesLow vaccination ratesCOVID-19 vaccinationVA healthcare systemHealthcare system approachCOVID-19 vaccinePublic health campaignsMotivational interviewing techniquesGOV IDENTIFIERUsual careVaccine discussionsFuture vaccinationPragmatic trialSevere illnessVaccine acceptanceSignificant disabilityImplementation facilitationVaccination decisionsHealth campaignsEffect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer
Cao A, Cartmel B, Li F, Gottlieb L, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Esserman D, Irwin M, Ferrucci L. Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer. JAMA Network Open 2023, 6: e2326463. PMID: 37526937, PMCID: PMC10394582, DOI: 10.1001/jamanetworkopen.2023.26463.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyAerobic exercise interventionAttention control armExercise intervention armExercise interventionOvarian cancerControl armIntervention armSecondary analysisCIPN symptomsPeripheral neuropathyLifestyle StudyTreatment of CIPNModerate-intensity aerobic exerciseStandard oncology careEffects of exerciseSevere adverse effectsBetween-group differencesAmerican Cancer SocietyQuality of lifeAttention controlCIPN severityPrimary outcomeOncology careAerobic exerciseMaximin optimal cluster randomized designs for assessing treatment effect heterogeneity
Ryan M, Esserman D, Li F. Maximin optimal cluster randomized designs for assessing treatment effect heterogeneity. Statistics In Medicine 2023, 42: 3764-3785. PMID: 37339777, PMCID: PMC10510425, DOI: 10.1002/sim.9830.Peer-Reviewed Original ResearchFacilitation and Preferred Models for Delivering Substance Use Disorder Treatment in HIV Clinics: Results From a Multisite Randomized Trial
Muvvala S, Gan G, Morford K, Dziura J, Esserman D, Porter E, Chan P, Cornman D, Reynolds J, Yager J, Fiellin D, Edelman E. Facilitation and Preferred Models for Delivering Substance Use Disorder Treatment in HIV Clinics: Results From a Multisite Randomized Trial. Journal Of Addiction Medicine 2023, 17: e388-e391. PMID: 37934538, PMCID: PMC10726383, DOI: 10.1097/adm.0000000000001192.Peer-Reviewed Original ResearchConceptsOpioid use disorderAlcohol use disorderTobacco use disorderHIV clinicUse disordersAddiction treatmentSubstance use disorder treatmentUse disorder treatmentMaintenance phaseRandomized trialsStaff preferencesImproved outcomesMultisite Randomized TrialImplementation facilitationDisorder treatmentControl phaseClinicCliniciansTreatment modelTreatmentDisordersSignificant differencesInterventionHigher proportionAddiction treatment modelsDesign, implementation and preliminary results of a type-2 hybrid cluster-randomized trial of integrating screening and treatment for major depressive disorder into specialty clinics providing opioid agonist therapies in Ukraine
Machavariani E, Bromberg D, Dumchev K, Dvoriak S, Zeziulin O, Morozova O, Esserman D, Pykalo I, Saichuk N, Ivasiy R, Haddad M, Altice F. Design, implementation and preliminary results of a type-2 hybrid cluster-randomized trial of integrating screening and treatment for major depressive disorder into specialty clinics providing opioid agonist therapies in Ukraine. Contemporary Clinical Trials 2023, 131: 107248. PMID: 37263492, PMCID: PMC10527419, DOI: 10.1016/j.cct.2023.107248.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyMajor depressive disorderCo-occurring disordersAgonist therapyDepressive disorderSpecialty clinicPsychiatric disordersPatient-level outcomesPrevalent psychiatric disordersCluster-randomized trialPoor health outcomesProvider-level dataMDD treatmentTreatment algorithmExperimental armHigh prevalenceDelivery outcomesHealth outcomesSerial surveysClinicPatientsProject ECHOSubstance useMonthsDisordersRental assistance improves food security and nutrition: An analysis of National Survey Data
Denary W, Fenelon A, Whittaker S, Esserman D, Lipska K, Keene D. Rental assistance improves food security and nutrition: An analysis of National Survey Data. Preventive Medicine 2023, 169: 107453. PMID: 36813247, PMCID: PMC10037672, DOI: 10.1016/j.ypmed.2023.107453.Peer-Reviewed Original ResearchConceptsRental assistanceNational quasi-experimental studyFood securityHousing affordability crisisComparable control groupDaily fruitMore cupsProject‐based assistanceEligible individualsVegetable consumptionCurrent unmetControl groupQuasi-experimental studyNational survey dataAffordability crisisHousing accessLong waitlistsAdverse health implicationsHealth implicationsFood insecurityWaitlistAverage wait timeWait timeHealth necessitySurvey data