2024
In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcomeAssociations of Social Support With Physical and Mental Health Symptom Burden After COVID-19 Hospitalization Among Older Adults
Lee S, McAvay G, Geda M, Chattopadhyay S, Acampora D, Araujo K, Charpentier P, Gill T, Hajduk A, Cohen A, Ferrante L. Associations of Social Support With Physical and Mental Health Symptom Burden After COVID-19 Hospitalization Among Older Adults. The Journals Of Gerontology Series A 2024, 79: glae092. PMID: 38558166, PMCID: PMC11059296, DOI: 10.1093/gerona/glae092.Peer-Reviewed Original ResearchConceptsLow social supportMental health symptomsSocial supportSymptom burdenHealth symptomsFollow-up assessmentCOVID-19 hospitalizationMedical Outcomes Study Social Support SurveyPhysical symptomsAssociation of social supportEdmonton Symptom Assessment SystemPatient Health Questionnaire-4Burden of physical symptomsMental health symptom burdenModified Edmonton Symptom Assessment SystemSocial Support SurveyParticipants' mean ageAssociated with higher burdenSupport SurveyOlder survivorsSymptom managementOlder AdultsMental healthHispanic ethnicityLongitudinal associations
2022
Rationale, Design, and Characteristics of the VALIANT (COVID‐19 in Older Adults: A Longitudinal Assessment) Cohort
Cohen A, McAvay G, Geda M, Chattopadhyay S, Lee S, Acampora D, Araujo K, Charpentier P, Gill T, Hajduk A, Ferrante L. Rationale, Design, and Characteristics of the VALIANT (COVID‐19 in Older Adults: A Longitudinal Assessment) Cohort. Journal Of The American Geriatrics Society 2022, 71: 832-844. PMID: 36544250, PMCID: PMC9877652, DOI: 10.1111/jgs.18146.Peer-Reviewed Original ResearchConceptsPatient-centered outcomesCOVID-19 hospitalizationCognitive impairmentPhysical functionOlder COVID-19 survivorsCOVID-19-related symptomsCOVID-19Older adultsIntensive care unitCOVID-19 survivorsPersistent cognitive impairmentSix-month followMost older adultsThird of participantsElectronic health recordsStepdown unitAcute illnessBurdensome symptomsCare unitSupplemental oxygenMedian lengthProspective studyMean ageBlack raceBaseline interview
2016
Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial
Juthani-Mehta M, Van Ness PH, Bianco L, Rink A, Rubeck S, Ginter S, Argraves S, Charpentier P, Acampora D, Trentalange M, Quagliarello V, Peduzzi P. Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial. JAMA 2016, 316: 1879-1887. PMID: 27787564, PMCID: PMC5300771, DOI: 10.1001/jama.2016.16141.Peer-Reviewed Original ResearchConceptsUrinary tract infectionPresence of bacteriuriaSymptomatic urinary tract infectionCranberry capsulesNursing homesOlder womenTreatment groupsControl groupPlacebo-controlled efficacy trialSignificant differencesRate of deathAntibiotic-resistant organismsControl group participantsCause deathStudy surveillanceCause hospitalizationSecondary outcomesTract infectionsPrimary outcomeOverall adherenceAntimicrobial utilizationClinical trialsEfficacy trialsPyuriaUnadjusted results
2008
Effect of Dissemination of Evidence in Reducing Injuries from Falls
Tinetti ME, Baker DI, King M, Gottschalk M, Murphy TE, Acampora D, Carlin BP, Leo-Summers L, Allore HG. Effect of Dissemination of Evidence in Reducing Injuries from Falls. New England Journal Of Medicine 2008, 359: 252-261. PMID: 18635430, PMCID: PMC3472807, DOI: 10.1056/nejmoa0801748.Peer-Reviewed Original ResearchConceptsFall-related injuriesSerious fall-related injuriesAdjusted ratesIntervention regionClinical practiceElderly personsPercentage of cliniciansPrimary care cliniciansPrevention of fallsMedical servicesRate of injuryYears of ageEvaluation periodDissemination of evidenceCare cliniciansIntervention visitsOutpatient rehabilitationPreintervention periodFall preventionMorbid conditionsNonrandomized designInjuryReducing InjuryCliniciansRegions of Connecticut
2007
A Randomized Trial of an Education Program to Enhance Older Driver Performance
Marottoli RA, Ness P, Araujo KL, Iannone LP, Acampora D, Charpentier P, Peduzzi P. A Randomized Trial of an Education Program to Enhance Older Driver Performance. The Journals Of Gerontology Series A 2007, 62: 1113-1119. PMID: 17921424, DOI: 10.1093/gerona/62.10.1113.Peer-Reviewed Original ResearchA Randomized Trial of a Physical Conditioning Program to Enhance the Driving Performance of Older Persons
Marottoli RA, Allore H, Araujo KL, Iannone LP, Acampora D, Gottschalk M, Charpentier P, Kasl S, Peduzzi P. A Randomized Trial of a Physical Conditioning Program to Enhance the Driving Performance of Older Persons. Journal Of General Internal Medicine 2007, 22: 590-597. PMID: 17443366, PMCID: PMC1852916, DOI: 10.1007/s11606-007-0134-3.Peer-Reviewed Original ResearchConceptsOlder driversRoad test scoreDriving performanceControl participantsPotential safety implicationsIntervention driversTest scoresDrivers increasesCognitive impairmentCritical errorsOverall ratingDriving maneuversTraffic situationsCommunity sourcesSpeed of movementParticipantsPositive toneRatingsPhysical conditioning programRoad performanceInterventionOlder personsSafety moduleConditioning programSafety implications
2001
Multicomponent Targeted Intervention to Prevent Delirium in Hospitalized Older Patients
Rizzo J, Bogardus S, Leo-Summers L, Williams C, Acampora D, Inouye S. Multicomponent Targeted Intervention to Prevent Delirium in Hospitalized Older Patients. Medical Care 2001, 39: 740-752. PMID: 11458138, DOI: 10.1097/00005650-200107000-00010.Peer-Reviewed Original ResearchConceptsHospitalized older personsOlder personsIntermediate riskRisk groupsHigh riskRisk factor intervention strategyCost-effective treatment optionHospitalized Older PatientsIntermediate-risk cohortPrevention of deliriumUsual hospital careIntermediate-risk groupOverall health care costsAcute confusional stateEffective treatment optionHigh-risk groupHealth care costsDelirium preventionPrevent DeliriumUsual careHospital daysOlder PatientsHospitalized patientsConfusional stateRisk cohort
1999
Home-based multicomponent rehabilitation program for older persons after hip fracture: A randomized trial
Tinetti M, Baker D, Gottschalk M, Williams C, Pollack D, Garrett P, Gill T, Marottoli R, Acampora D. Home-based multicomponent rehabilitation program for older persons after hip fracture: A randomized trial. Archives Of Physical Medicine And Rehabilitation 1999, 80: 916-922. PMID: 10453768, DOI: 10.1016/s0003-9993(99)90083-7.Peer-Reviewed Original ResearchConceptsMulticomponent rehabilitation programUsual careHip fractureRehabilitation programExtremity strengthOlder personsBetter gait performanceSelf-care ADLDaily living (ADL) disabilityDuration of rehabilitationOptimal functional recoveryProportion of participantsRehabilitation strategiesLower extremity strengthUpper extremity strengthYears of ageHome-based rehabilitationSocial activity levelsHome care servicesPrefracture levelSurgical repairFunctional recoveryImproved outcomesGait performanceHome care agenciesA Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients
Inouye S, Bogardus S, Charpentier P, Leo-Summers L, Acampora D, Holford T, Cooney L. A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients. New England Journal Of Medicine 1999, 340: 669-676. PMID: 10053175, DOI: 10.1056/nejm199903043400901.Peer-Reviewed Original ResearchConceptsSeverity of deliriumRisk factorsCognitive impairmentRecurrence rateIntervention groupRisk factor intervention strategyHearing impairmentVisual impairmentHospitalized Older PatientsPatients 70 yearsPrevention of deliriumUsual care unitsUsual care groupGeneral medicine serviceEffective treatment strategiesDuration of episodesPrevent DeliriumOlder patientsRate of usePrimary outcomeSleep medicationPoor outcomePrimary preventionPatient's deliriumTeaching hospital
1998
Health Care Utilization and Costs in a Medicare Population by Fall Status
Rizzo J, Friedkin R, Williams C, Nabors J, Acampora D, Tinetti M. Health Care Utilization and Costs in a Medicare Population by Fall Status. Medical Care 1998, 36: 1174-1188. PMID: 9708590, DOI: 10.1097/00005650-199808000-00006.Peer-Reviewed Original ResearchMeSH KeywordsAccidental FallsAgedCenters for Medicare and Medicaid Services, U.S.ConnecticutFemaleFollow-Up StudiesHealth Care CostsHealth Care SurveysHealth ServicesHealth StatusHumansInjury Severity ScoreLogistic ModelsLong-Term CareMaleMedicareMultivariate AnalysisRegistriesSocioeconomic FactorsUnited StatesConceptsHealth care costsCare costsOlder personsTotal health care costsEmergency room costsHealth care utilizationSeverity of fallsAnnual hospital costsHealth Care Financing AdministrationPublic health practitionersNoninjurious fallsNursing home costsInjurious fallsCare registriesCare utilizationHospital costsFall statusMedicare populationHome healthNursing homesFall frequencyRoom costsFall severitySame time periodHealth practitioners
1993
A Controlled Trial of a Nursing‐Centered Intervention in Hospitalized Elderly Medical Patients: The Yale Geriatric Care Program
Inouye S, Wagner D, Acampora D, Horwitz R, Cooney L, Tinetii M. A Controlled Trial of a Nursing‐Centered Intervention in Hospitalized Elderly Medical Patients: The Yale Geriatric Care Program. Journal Of The American Geriatrics Society 1993, 41: 1353-1360. PMID: 8227919, DOI: 10.1111/j.1532-5415.1993.tb06487.x.Peer-Reviewed Original ResearchConceptsElderly medical patientsFunctional declineMedical patientsBeneficial effectsIntervention groupRelative riskHospitalized elderly medical patientsGeriatric care teamsFrail older patientsProspective cohort studyGeneral medicine wardsUniversity Teaching HospitalGeriatric care programSignificant beneficial effectIntervention patientsADL scoresCohort studyOlder patientsMedicine wardsControl subjectsHospital costsCare teamTeaching hospitalPhysical therapyStratified analysisA predictive index for functional decline in hospitalized elderly medical patients
Inouye S, Wagner D, Acampora D, Horwitz R, Cooney L, Hurst L, Tinetti M. A predictive index for functional decline in hospitalized elderly medical patients. Journal Of General Internal Medicine 1993, 8: 645-652. PMID: 8120679, DOI: 10.1007/bf02598279.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overChi-Square DistributionCohort StudiesConnecticutFemaleGeriatric AssessmentHospital Bed Capacity, 500 and overHospitals, UniversityHumansLikelihood FunctionsMaleMultivariate AnalysisPrevalenceProportional Hazards ModelsProspective StudiesReproducibility of ResultsRisk FactorsSingle-Blind MethodConceptsFunctional declineRisk factorsMedical patientsValidation cohortDevelopment cohortHospitalized elderly medical patientsIndependent baseline risk factorsLow social activity levelNumber of RFsPredictive indexBaseline risk factorsGeneral medical wardsProspective cohort studyGeneral medical patientsHigh-risk groupUniversity Teaching HospitalElderly medical patientsRisk stratification systemNursing home placementRate of deathSocial activity levelsComparable patientsCohort studyElderly patientsMedical wardsPredictors of Formal Home Health Care Use in Elderly Patients after Hospitalization
Solomon D, Wagner D, Marenberg M, Acampora D, Cooney L, Inouye S. Predictors of Formal Home Health Care Use in Elderly Patients after Hospitalization. Journal Of The American Geriatrics Society 1993, 41: 961-966. PMID: 8409182, DOI: 10.1111/j.1532-5415.1993.tb06762.x.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAge FactorsAgedAged, 80 and overComorbidityConfidence IntervalsEducational StatusFemaleForecastingGeriatric AssessmentHealth PlanningHealth Services ResearchHome Care ServicesHospitalizationHumansMalePatient DischargePatient ReadmissionProportional Hazards ModelsProspective StudiesRisk FactorsSeverity of Illness IndexSocial SupportConceptsHome health care useHealth care useRisk factorsAcute careElderly patientsSurgical patientsCare useHHC useProspective cohort studyRisk factor presentUniversity Teaching HospitalCohort studyHospital dischargeMedian durationIndependent predictorsSurgical wardsRisk strataDischarge planningTeaching hospitalInstrumental activitiesDaily livingElderly populationHHC agenciesStudy catchment areaPatients
1989
New Epidemiologic Evidence Confirming That Bias Does Not Explain the Aspirin/Reye's Syndrome Association
Forsyth B, Horwitz R, Acampora D, Shapiro E, Viscoli C, Feinstein A, Henner R, Holabird N, Jones B, Karabelas A, Kramer M, Miclette M, Wells J. New Epidemiologic Evidence Confirming That Bias Does Not Explain the Aspirin/Reye's Syndrome Association. JAMA 1989, 261: 2517-2524. PMID: 2704111, DOI: 10.1001/jama.1989.03420170061031.Peer-Reviewed Original ResearchConceptsSyndrome AssociationCase subjectsMedical record review studyRecord review studyCase-control studyNew epidemiologic evidencePotential recall biasSeverity of symptomsEpidemiologic evidenceReye's syndromeEpidemiologic investigationsControl groupDiagnostic biasSusceptibility biasRecall biasBiphasic patternSyndromeAssociationReview studyPotential sourceSubjectsAspirinHospitalIllnessSymptoms
1988
Relation of peak creatine kinase levels during acute myocardial infarction to presence or absence of previous manifestations of myocardial ischemia (angina pectoris or healed myocardial infarction)
Brush J, Brand D, Acampora D, Goldman J, Cabin H. Relation of peak creatine kinase levels during acute myocardial infarction to presence or absence of previous manifestations of myocardial ischemia (angina pectoris or healed myocardial infarction). The American Journal Of Cardiology 1988, 62: 534-537. PMID: 3414544, DOI: 10.1016/0002-9149(88)90650-9.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPositive history groupCK-MB levelsPeak CK-MB levelPeak creatine kinase levelPrevious anginaCreatine kinase levelsMyocardial infarctionKinase levelsMean peak creatine kinase levelPrevious coronary artery bypassRecent acute myocardial infarctionCoronary artery bypassBeta-blocking agentsLarge myocardial infarctionHistory groupHigher peak CKArtery bypassHospital complicationsStreptokinase administrationMyocardial ischemiaPeak CKAnginaPrevious historyPatientsA Computer Protocol to Predict Myocardial Infarction in Emergency Department Patients with Chest Pain
Goldman L, Cook E, Brand D, Lee T, Rouan G, Weisberg M, Acampora D, Stasiulewicz C, Walshon J, Terranova G, Gottlieb L, Kobernick M, Goldstein-Wayne B, Copen D, Daley K, Brandt A, Jones D, Mellors J, Jakubowski R. A Computer Protocol to Predict Myocardial Infarction in Emergency Department Patients with Chest Pain. New England Journal Of Medicine 1988, 318: 797-803. PMID: 3280998, DOI: 10.1056/nejm198803313181301.Peer-Reviewed Original ResearchConceptsCoronary care unitAdmission of patientsCare unitMyocardial infarctionUnaided physiciansChest painAcute chest painAbsence of infarctionEmergency department patientsCareful clinical judgmentPresence of infarctionDepartment patientsIntensive careEmergent complicationsUniversity HospitalAppropriate triageCommunity hospitalClinical dataInfarctionPatientsClinical judgmentAdmissionHospitalPhysiciansPain
1987
Clinical characteristics and natural history of patients with acute myocardial infarction sent home from the emergency room
Lee T, Rouan G, Weisberg M, Brand D, Acampora D, Stasiulewicz C, Walshon J, Terranova G, Gottlieb L, Goldstein-Wayne B, Copen D, Daley K, Brandt A, Mellors J, Jakubowski R, Cook E, Goldman L. Clinical characteristics and natural history of patients with acute myocardial infarction sent home from the emergency room. The American Journal Of Cardiology 1987, 60: 219-224. PMID: 3618483, DOI: 10.1016/0002-9149(87)90217-7.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionEmergency roomMissed Acute Myocardial InfarctionPrior acute myocardial infarctionShort-term mortality rateProspective multicenter investigationAcute chest painIschemic electrocardiographic changesAdmission of patientsEmergency room patientsChest painIschemic painClinical characteristicsElectrocardiographic evidencePersistent symptomsAMI patientsElectrocardiographic changesMulticenter investigationSame hospitalTypical presentationRoom patientsIndependent reviewersPatientsMortality rateSensitivity of routine clinical criteria for diagnosing myocardial infarction within 24 hours of hospitalization.
Lee T, Rouan G, Weisberg M, Brand D, Cook E, Acampora D, Goldman L. Sensitivity of routine clinical criteria for diagnosing myocardial infarction within 24 hours of hospitalization. Annals Of Internal Medicine 1987, 106: 181-6. PMID: 3800180, DOI: 10.7326/0003-4819-106-2-181.Peer-Reviewed Original ResearchConceptsRecurrent ischemic painHours of admissionMyocardial infarctionIschemic painChest painEnzyme abnormalitiesDiagnostic criteriaRecurrent chest painAcute chest painHours of hospitalizationIntermediate care unitRoutine clinical criteriaCare unitClinical criteriaCommunity hospitalInfarctionPainPatientsEnzyme testingAdmissionAbnormalitiesIndependent testing setHoursSufficient periodHospitalization