2017
Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS
Garg D, Grazi R, Lambert-Messerlian GM, Merhi Z. Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS. Journal Of Assisted Reproduction And Genetics 2017, 34: 1507-1513. PMID: 28825156, PMCID: PMC5699991, DOI: 10.1007/s10815-017-1011-6.Peer-Reviewed Original ResearchConceptsAdvanced glycation end productsFollicular fluidVitamin DPro-inflammatory advanced glycation end productsHigher anti-Mullerian hormone levelsAnti-Mullerian hormone levelsProtective anti-inflammatory roleFollicular fluid levelsLevels of sRAGEAnti-inflammatory rolePathogenesis of PCOSGlycation end productsPotential therapeutic targetDay 5 embryosConclusionsIn womenSRAGE levelsOvarian dysfunctionOvarian levelHormone levelsPCOSSRAGESoluble receptorTherapeutic targetDay 3Fluid levels
2016
Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS
Garg D, Merhi Z. Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS. Reproductive Biology And Endocrinology 2016, 14: 71. PMID: 27769286, PMCID: PMC5073880, DOI: 10.1186/s12958-016-0205-6.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxysteroid DehydrogenasesAnimalsCholesterol Side-Chain Cleavage EnzymeFemaleGlycation End Products, AdvancedGonadal Steroid HormonesGranulosa CellsHumansOvaryPhosphoproteinsPolycystic Ovary SyndromeReceptors, LHReceptors, PeptideReceptors, Transforming Growth Factor betaSteroid 17-alpha-HydroxylaseTheca CellsConceptsAdvanced glycation end productsOvaries of womenTheca cell functionGlycation end productsCell functionHormone receptor expressionSteroidogenic enzyme activitiesSteroidogenic acute regulatory proteinAbnormal steroidogenesisPCOS modelOvarian dysfunctionAcute regulatory proteinReceptor expressionPCOSFollicular developmentTheca cellsGranulosa cellsSystematic reviewNew interventionsHormone receptorsEnzyme cytochrome P450SteroidogenesisEnd productsGranulosaCytochrome P450The role of AMH in the pathophysiology of polycystic ovarian syndrome
Garg D, Tal R. The role of AMH in the pathophysiology of polycystic ovarian syndrome. Reproductive BioMedicine Online 2016, 33: 15-28. PMID: 27174394, DOI: 10.1016/j.rbmo.2016.04.007.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeAnti-Müllerian hormoneOvarian syndromePathophysiology of PCOSTreatment of PCOSRole of AMHLaparoscopic ovarian drillingReproductive-age womenSerum AMH concentrationsNew treatment modalitiesFollicular arrestOvarian drillingOvulation inductionClinical parametersInsulin resistanceAMH concentrationsTreatment modalitiesAge womenEndocrine alterationsPoor responseAromatase productionAMH declinePCOS pathogenesisFollicular developmentHelp clinicians
2015
Advanced Glycation End Products: Link between Diet and Ovulatory Dysfunction in PCOS?
Garg D, Merhi Z. Advanced Glycation End Products: Link between Diet and Ovulatory Dysfunction in PCOS? Nutrients 2015, 7: 10129-10144. PMID: 26690206, PMCID: PMC4690076, DOI: 10.3390/nu7125524.Peer-Reviewed Original ResearchMeSH KeywordsDietFemaleGlycation End Products, AdvancedHumansInsulin ResistanceObesityPolycystic Ovary SyndromeReceptor for Advanced Glycation End ProductsReproductionConceptsOvulatory dysfunctionAdvanced glycation end productsHigh AGE dietReproductive-aged womenPro-inflammatory receptorGlycation end productsDietary AGEsPharmacological therapyOvulatory problemsExpression of AGEsCommon causeOvarian healthPCOSOvarian tissueAnovulationModification of foodVariety of dietsWomenAgeDysfunctionDietReproductive alterationsSubsequent developmentNon-enzymatic reactionEnd products