2023
Outcomes of immunomodulator and advanced therapies for primary sclerosing cholangitis-associated inflammatory bowel disease
Sayed A, Assis D, Silveira M, Deng Y, Ciarleglio M, Gaidos J, Proctor D, Al-Bawardy B. Outcomes of immunomodulator and advanced therapies for primary sclerosing cholangitis-associated inflammatory bowel disease. European Journal Of Gastroenterology & Hepatology 2023, 35: 270-274. PMID: 36708297, DOI: 10.1097/meg.0000000000002510.Peer-Reviewed Original ResearchConceptsPrimary sclerosing cholangitisInflammatory bowel diseasePSC-IBDEndoscopic healingTherapy groupAdvanced therapiesClinical remissionBowel diseaseAcute ascending cholangitisRate of cholangitisSmall bowel involvementThird of patientsAscending cholangitisSclerosing cholangitisAdult patientsBowel involvementSecondary outcomesMedian agePrimary outcomeRetrospective studyHigh riskCholangitisPatientsTherapyLarger study
2020
The Impact of Vedolizumab on Pre-Existing Extraintestinal Manifestations of Inflammatory Bowel Disease: A Multicenter Study
Ramos GP, Dimopoulos C, McDonald NM, Janssens LP, Hung KW, Proctor D, Ruggiero E, Kane S, Bruining DH, Faubion WA, Raffals LE, Loftus EV, Al-Bawardy B. The Impact of Vedolizumab on Pre-Existing Extraintestinal Manifestations of Inflammatory Bowel Disease: A Multicenter Study. Inflammatory Bowel Diseases 2020, 27: 1270-1276. PMID: 33165569, DOI: 10.1093/ibd/izaa293.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseExtraintestinal manifestationsPeripheral arthritisBowel diseaseDose of vedolizumabPrevious biologic useMulticenter retrospective studyCurrent medical therapyTerms of ageConcurrent immunosuppressantsCorticosteroid therapyVDZ treatmentIBD subtypesBiologic useSecondary outcomesMedical therapyPrimary outcomeClinical outcomesMulticenter studyRetrospective studyVedolizumabPatientsCommon typeDiscontinuationArthritisSleep Characteristics and Rest–Activity Rhythms Are Associated with Gastrointestinal Symptoms Among Adults with Inflammatory Bowel Disease
Conley S, Jeon S, Lehner V, Proctor DD, Redeker NS. Sleep Characteristics and Rest–Activity Rhythms Are Associated with Gastrointestinal Symptoms Among Adults with Inflammatory Bowel Disease. Digestive Diseases And Sciences 2020, 66: 181-189. PMID: 32193859, PMCID: PMC8162988, DOI: 10.1007/s10620-020-06213-6.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseRest-activity rhythmHeartburn/refluxDisease activityGI symptomsSleep characteristicsBowel diseaseGas/bloatingCross-sectional studySpecific sleep characteristicsRAR variablesGastrointestinal symptomsIntra-daily variabilityBackgroundSleep disturbancesSleep efficiencyAimsThe purposeSleep onsetSymptomsAdultsDiseaseRefluxPoor qualityAssociationRhythmRemission
2018
Longitudinal Changes in Symptom Cluster Membership in Inflammatory Bowel Disease
Conley S, Jeon S, Proctor DD, Sandler RS, Redeker NS. Longitudinal Changes in Symptom Cluster Membership in Inflammatory Bowel Disease. Journal Of Nursing Scholarship 2018, 50: 473-481. PMID: 29971936, PMCID: PMC6120775, DOI: 10.1111/jnu.12409.Peer-Reviewed Original ResearchConceptsSymptom cluster membershipInflammatory bowel diseaseSymptom burdenBowel diseaseLower symptom burdenPsychological symptoms groupSymptom management optionsHigh symptom burdenRetrospective longitudinal studyLatent transition analysisActive diseaseClinical factorsPain interferenceColitis FoundationSleep disturbancesCluster membershipHigh burdenMultiple symptomsSymptom groupsPhysical symptomsPsychological symptomsLow burdenSymptom clustersLongitudinal changesSymptoms
2017
Knowledge Gaps in the Management of Postoperative Crohn’s Disease: A US National Survey
Nguyen VQ, Mays JL, Lang M, Wu Y, Dassopoulos T, Regueiro M, Moss A, Proctor DD, Sorrentino D. Knowledge Gaps in the Management of Postoperative Crohn’s Disease: A US National Survey. Digestive Diseases And Sciences 2017, 63: 53-60. PMID: 29147878, DOI: 10.1007/s10620-017-4844-z.Peer-Reviewed Original ResearchConceptsMedical prophylaxisCrohn's diseaseEndoscopic findingsClinical practicePostoperative Crohn's diseasePrior intestinal surgerySubsequent endoscopic findingsHigh-risk patientsEndoscopic scoring systemEarly disease onsetHigh-risk factorsAmerican Gastroenterological AssociationCurrent clinical practiceCombination of symptomsBackgroundPostoperative recurrenceUS National SurveyEndoscopic recurrenceCD patientsClinical recurrenceIntestinal surgeryMajority of participantsPerianal fistulasResultsA totalDisease onsetPatient riskSymptom clusters in adults with inflammatory bowel disease
Conley S, Proctor DD, Jeon S, Sandler RS, Redeker NS. Symptom clusters in adults with inflammatory bowel disease. Research In Nursing & Health 2017, 40: 424-434. PMID: 28833284, PMCID: PMC5597486, DOI: 10.1002/nur.21813.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseSymptom burdenBowel diseaseHigh symptom burden groupSymptom clustersOutcomes Measurement Information System (PROMIS) measuresLower symptom burdenHigh symptom burdenActive disease stateLatent class analysisSymptom management interventionsSymptom cluster groupsSymptom cluster membershipClinical factorsCrohn's diseasePain interferenceBurden groupRetrospective studyColitis FoundationSleep disturbancesFemale genderReduced qualityPhysical symptomsPsychological symptomsSymptoms
2016
JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages
Hedl M, Proctor DD, Abraham C. JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages. The Journal Of Immunology 2016, 197: 3695-3704. PMID: 27664279, PMCID: PMC5127452, DOI: 10.4049/jimmunol.1600845.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseAnti-inflammatory cytokinesImmune-mediated diseasesOligomerization domain 2Proinflammatory cytokinesMyeloid cellsJAK2 expressionJAK inhibitorsIntestinal myeloid cellsThymic stromal lymphopoietinUlcerative colitis patientsProinflammatory cytokine secretionPattern recognition receptorsHuman myeloid cellsLower JAK2Cell typesColitis patientsBowel diseaseIL-10IL-22Peripheral macrophagesIL-4Cytokine secretionAA carriersDecreased responseGlobal Health Education in Gastroenterology Fellowship: A National Survey
Jirapinyo P, Hunt RS, Tabak YP, Proctor DD, Makrauer FL. Global Health Education in Gastroenterology Fellowship: A National Survey. Digestive Diseases And Sciences 2016, 61: 3443-3450. PMID: 27796765, DOI: 10.1007/s10620-016-4308-x.Peer-Reviewed Original ResearchConceptsHealth educationIntrahepatic duct stonesElectronic survey studyAmerican Gastroenterological AssociationGastroenterology fellowship programsGlobal health educationFellowship programsHepatitis BHepatitis EDuct stonesInfectious enteritisGastroenterological AssociationResultsThe questionnaireProgram directorsGastroenterology fellowsGastroenterology fellowshipGastroenterology trainingGlobal health curriculaHealth curriculumUnderserved areasMost fellowsGH educationAdequate experienceFellowship curriculumNational surveyAppendectomy does not decrease the risk of future colectomy in UC: results from a large cohort and meta-analysis
Parian A, Limketkai B, Koh J, Brant SR, Bitton A, Cho JH, Duerr RH, McGovern DP, Proctor DD, Regueiro MD, Rioux JD, Schumm P, Taylor KD, Silverberg MS, Steinhart AH, Hernaez R, Lazarev M. Appendectomy does not decrease the risk of future colectomy in UC: results from a large cohort and meta-analysis. Gut 2016, 66: 1390. PMID: 27196594, PMCID: PMC5065377, DOI: 10.1136/gutjnl-2016-311550.Peer-Reviewed Original ResearchConceptsUC diagnosisDisease courseImpact of appendectomyRisk of colectomyTiming of appendectomyIndependent risk factorMilder disease courseSeverity of diseaseDevelopment of UCColectomy rateFuture colectomyEarly appendectomyClinical courseMultivariable analysisRisk factorsAppendectomyColectomyLarge cohortHigh riskPatientsDiagnosisConsortium databaseNational InstituteRiskUC
2013
EMerging BiomARKers in Inflammatory Bowel Disease (EMBARK) Study Identifies Fecal Calprotectin, Serum MMP9, and Serum IL-22 as a Novel Combination of Biomarkers for Crohn's Disease Activity: Role of Cross-Sectional Imaging
Faubion WA, Fletcher JG, O'Byrne S, Feagan BG, de Villiers WJ, Salzberg B, Plevy S, Proctor DD, Valentine JF, Higgins PD, Harris JM, Diehl L, Wright L, Tew GW, Luca D, Basu K, Keir ME. EMerging BiomARKers in Inflammatory Bowel Disease (EMBARK) Study Identifies Fecal Calprotectin, Serum MMP9, and Serum IL-22 as a Novel Combination of Biomarkers for Crohn's Disease Activity: Role of Cross-Sectional Imaging. The American Journal Of Gastroenterology 2013, 108: 1891. PMID: 24126633, DOI: 10.1038/ajg.2013.354.Peer-Reviewed Original ResearchConceptsComputed tomography enterographySerum IL-22Disease activityFecal calprotectinCrohn's diseaseSerum MMP9Ulcerative colitisCross-sectional imagingCD patientsIL-22Serum matrix metalloproteinase-9Bowel wall inflammationInflammatory disease activitySerum interleukin‐22Inflammatory bowel diseaseFindings of inflammationCrohn's disease activityMatrix metalloproteinase-9Endoscopy subscoreTomography enterographyUC patientsEndoscopy scoresBowel diseaseClinical symptomsWall inflammation
2011
Prospective Evaluation of Acute Graft-Versus-Host Disease
Aslanian H, Chander B, Robert M, Cooper D, Proctor D, Seropian S, Jain D. Prospective Evaluation of Acute Graft-Versus-Host Disease. Digestive Diseases And Sciences 2011, 57: 720-725. PMID: 22011927, DOI: 10.1007/s10620-011-1938-x.Peer-Reviewed Original ResearchConceptsAcute GVHDHost diseaseLower endoscopyRectal biopsyDiagnostic yieldGastrointestinal tractAllogeneic bone marrow transplantationAcute Graft-VersusCases of GVHDLower gastrointestinal involvementOptimal endoscopic approachDiagnosis of GVHDNon-specific symptomsStem cell transplantationBone marrow transplantationUpper gastrointestinal tractLower gastrointestinal tractUpper intestinal tractMajority of casesColonic GVHDGastrointestinal GVHDGastrointestinal involvementGraft-VersusGVHD casesIntestinal GVHDLittoral cell angioma of the spleen diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration biopsy
Nagarajan P, Cai G, Padda MS, Selbst M, Kowalski D, Proctor DD, Chhieng D, Aslanian HR, Harigopal M. Littoral cell angioma of the spleen diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration biopsy. Diagnostic Cytopathology 2011, 39: 318-322. PMID: 21488173, DOI: 10.1002/dc.21384.Peer-Reviewed Original ResearchConceptsEndoscopic ultrasound-guided fine-needle aspiration biopsyLittoral cell angiomaUltrasound-guided fine-needle aspiration biopsyFine-needle aspiration biopsyCytologic featuresAspiration biopsyEndoscopic ultrasound examinationCharacteristic cytologic featuresPrevious case reportsFine-needle aspiration samplesNeedle aspiration biopsyPrimary vascular neoplasmSplenic red pulpCase reportVascular lesionsVascular neoplasmUltrasound examinationImmunohistochemical analysisAspiration samplesAngiomaRed pulpSinusoidal lining
2009
Phenotypic and Genotypic Characteristics of Inflammatory Bowel Disease in French Canadians: Comparison With a Large North American Repository
Elkadri A, Bitton A, Cohen A, Griffiths A, Deslandres C, Proctor D, McGovern D, Langelier D, Bernard E, Torres E, Wild G, Nguyen G, Jobin G, Aumais G, Steinhart H, Rioux J, Cho J, Bhat M, Silverberg M, Regueiro M, Goyette P, Pare P, Lahaie R, Duerr R, Brant S, Dassopoulos T. Phenotypic and Genotypic Characteristics of Inflammatory Bowel Disease in French Canadians: Comparison With a Large North American Repository. The American Journal Of Gastroenterology 2009, 104: 2233. PMID: 19513023, PMCID: PMC2742627, DOI: 10.1038/ajg.2009.267.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseCrohn's diseaseBowel diseaseUlcerative colitisSingle nucleotide polymorphismsManagement of IBDCaucasian IBD populationsSmall bowel diseaseFrench-Canadian patientsExtraintestinal manifestationsCurrent smokersFormer smokersIBD phenotypeIBD populationCD patientsSmoking statusIncreased prevalenceKidney diseaseSurgical historyCaucasian patientsDisease behaviorFamily historyPatientsAnatomical locationDisease
2008
Hormonal Therapy for the Treatment of Gastrointestinal Bleeding in Hereditary Hemorrhagic Telangiectasia
Proctor DD, Henderson KJ, Dziura JD, White RI. Hormonal Therapy for the Treatment of Gastrointestinal Bleeding in Hereditary Hemorrhagic Telangiectasia. Journal Of Clinical Gastroenterology 2008, 42: 756-757. PMID: 18496387, DOI: 10.1097/mcg.0b013e318032391f.Peer-Reviewed Original Research
2005
Enteroscopic Evaluation of the Gastrointestinal Tract in Symptomatic Patients With Hereditary Hemorrhagic Telangiectasia
Proctor DD, Henderson KJ, Dziura JD, Longacre AV, White RI. Enteroscopic Evaluation of the Gastrointestinal Tract in Symptomatic Patients With Hereditary Hemorrhagic Telangiectasia. Journal Of Clinical Gastroenterology 2005, 39: 115-119. PMID: 15681905, DOI: 10.1097/01.mcg.0000150193.15978.f9.Peer-Reviewed Original ResearchConceptsHereditary hemorrhagic telangiectasiaStomach/duodenumHemorrhagic telangiectasiaGastrointestinal bleedingNumber of telangiectasesSymptomatic adult patientsCross-sectional studyAutosomal dominant diseaseDistal stomachSymptomatic patientsAdult patientsMedian numberIndividual patientsGastrointestinal tractPatientsTelangiectasesDuodenumJejunal onesJejunumLarger telangiectasesStomachDominant diseaseBleedingAnemiaTelangiectasia
2003
Role of Interstitial Cells of Cajal in Motility Disorders of the Bowel
Jain D, Moussa K, Tandon M, Culpepper-Morgan J, Proctor DD. Role of Interstitial Cells of Cajal in Motility Disorders of the Bowel. The American Journal Of Gastroenterology 2003, 98: ajg2003146. PMID: 12650797, DOI: 10.1111/j.1572-0241.2003.07295.x.Peer-Reviewed Original ResearchConceptsMechanical bowel obstructionMotility disordersBowel obstructionNormal controlsInterstitial cellsPolyclonal c-kit antibodyAge-matched normal controlsBowel motility disordersNeonatal meconium ileusSpecific histological changesAdministration of drugsIndirect immunoperoxidase methodC-kit antibodyBowel dysmotilityMechanical obstructionSystemic disordersMeconium ileusC-kit receptorHistological changesNeuropathic formPatientsPatchy areasImmunoperoxidase methodMasson's trichromeIntestinal tractDiagnosis and Management of Gastrointestinal Bleeding in Patients With Hereditary Hemorrhagic Telangiectasia
Longacre AV, Gross CP, Proctor D, Henderson KJ, Gallitelli M, White R. Diagnosis and Management of Gastrointestinal Bleeding in Patients With Hereditary Hemorrhagic Telangiectasia. The American Journal Of Gastroenterology 2003, 98: 59. PMID: 12526937, DOI: 10.1111/j.1572-0241.2003.07185.x.Peer-Reviewed Original ResearchConceptsBlood transfusion requirementsHereditary hemorrhagic telangiectasiaTransfusion requirementsGI bleedingMean HbDrug therapyHHT patientsHemorrhagic telangiectasiaEthinyl estradiol/norethindroneHigher blood transfusion requirementsIndividual patient basisLower mean HbGastrointestinal bleedingMean followRed blood cellsConsecutive patientsEndoscopic treatmentSignificant bleedingMean ageClinical evaluationBleedingPatient basisPatientsOptimal managementAminocaproic acid