2024
An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis
Ramakrishnan D, Farhat L, Vattimo E, Levine J, Johnson J, Artukoglu B, Landeros-Weisenberger A, Zangen A, Pelissolo A, de B Pereira C, Rück C, Costa D, Mataix-Cols D, Shannahoff-Khalsa D, Tolin D, Zarean E, Meyer E, Hawken E, Storch E, Andersson E, Miguel E, Maina G, Leckman J, Sarris J, March J, Diniz J, Kobak K, Mallet L, Vulink N, Amiaz R, Fernandes R, Shavitt R, Wilhelm S, Golshan S, Tezenas du Montcel S, Erzegovesi S, Baruah U, Greenberg W, Kobayashi Y, Bloch M. An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis. Journal Of Psychiatric Research 2024, 173: 387-397. PMID: 38598877, DOI: 10.1016/j.jpsychires.2024.03.044.Peer-Reviewed Original ResearchConceptsYale-Brown Obsessive-Compulsive ScaleObsessive-compulsive disorderCGI-IRandomized-controlled trialsAdult obsessive-compulsive disorderClinical Global Impression ImprovementObsessive-Compulsive ScaleTreatment responseIndividual-patient data meta-analysisPosttreatment scoresEvaluation of treatment responseMeta-analysis of randomized-controlled trialsFirst-line therapyCGIIndividual participant dataMeta-analysisNovel treatment modalitiesExpert consensusIndividual participant data meta-analysisSystematic reviewDisordersData meta-analysisPosttreatmentRemission definitionsImpressive improvement
2023
Changes in Neural Activity Following a Randomized Trial of Cognitive Behavioral Therapy for Hoarding Disorder
Tolin D, Levy H, Hallion L, Wootton B, Jaccard J, Diefenbach G, Stevens M. Changes in Neural Activity Following a Randomized Trial of Cognitive Behavioral Therapy for Hoarding Disorder. Journal Of Consulting And Clinical Psychology 2023, 91: 242-250. PMID: 36877480, PMCID: PMC10175200, DOI: 10.1037/ccp0000804.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyMedial intraparietal areaDorsal anterior cingulate cortexIntraparietal areaHD patientsRostral cingulateDorsolateral prefrontalBehavioral therapyVentral insular cortexDACC activationAnterior intraparietal areaNeural activityGroup cognitive behavioral therapyAnterior cingulate cortexRight dorsolateral prefrontalFunctional magnetic resonance imagingMagnetic resonance imagingCaudal cingulateClinical trialsInsular cortexRight amygdalaTherapeutic benefitSymptom reductionCingulate cortexResonance imagingThe DIAMOND-KID: Psychometric Properties of a Structured Diagnostic Interview for DSM-5 Anxiety, Mood, and Obsessive-Compulsive and Related Disorders in Children and Adolescents
Tolin D, Sain K, Davis E, Gilliam C, Hannan S, Springer K, Stubbing J, George J, Jean A, Goldblum R, Katz B, Everhardt K, Darrow S, Ohr E, Young M, Serchuk M. The DIAMOND-KID: Psychometric Properties of a Structured Diagnostic Interview for DSM-5 Anxiety, Mood, and Obsessive-Compulsive and Related Disorders in Children and Adolescents. Assessment 2023, 30: 2351-2363. PMID: 36632642, DOI: 10.1177/10731911221143994.Peer-Reviewed Original ResearchConceptsSelf-report measuresDiagnostic InterviewSemi-structured diagnostic interviewObsessive-compulsive disorderGeneralized anxiety disorderSymptoms of anxietyDSM-5 AnxietyPediatric psychiatric disordersTest-retest reliability dataDisorder childrenAdolescent versionTest-retest reliabilityObsessive-CompulsiveAnxiety disordersConvergent validitySemi-structured interviewsQuestionable rangePsychometric propertiesAnxietyMoodRelated disordersInterrater reliability dataInitial interviewParents/guardiansGroup comparisons
2022
Central and peripheral nervous system responses to chronic and paced hyperventilation in anxious and healthy subjects
Tolin D, O'Bryan E, Davies C, Diefenbach G, Johannesen J. Central and peripheral nervous system responses to chronic and paced hyperventilation in anxious and healthy subjects. Biological Psychology 2022, 176: 108472. PMID: 36481266, PMCID: PMC9839632, DOI: 10.1016/j.biopsycho.2022.108472.Peer-Reviewed Original ResearchConceptsAnxious patientsCentral nervous system correlatesPeripheral nervous system responsesAlpha-1 powerPeripheral nervous systemFurther treatment developmentNervous system responsesHealthy control participantsHypocapnic patientsNormocapnic patientsChronic hyperventilationRespiratory distressEEG abnormalitiesHealthy subjectsSkin conductance levelNervous systemPatientsControl groupHealthy participantsPoor toleranceTreatment developmentSkin conductance response amplitudeControl participantsBreathing taskMechanistic targetMechanisms of Action in Exposure Therapy
Knowles K, Tolin D. Mechanisms of Action in Exposure Therapy. Current Psychiatry Reports 2022, 24: 861-869. PMID: 36399234, DOI: 10.1007/s11920-022-01391-8.Peer-Reviewed Original ResearchConceptsExposure-based interventionsExposure therapyReturn of fearAnxiety-related disordersExtinction learningFear extinctionNeural levelPrefrontal regionsNeurobiological mechanismsSafety behaviorSuch translational researchTherapy workPromising future directionsBehavioral mechanismsPharmacological augmentationMixed resultsBehavioral changesIncreased activationFull symptom reliefMultiple levelsFuture directionsRecent FindingsRecent studiesSymptom improvementMechanism of actionSymptom reliefCo-occurring Obsessive-Compulsive Disorder and Hoarding Disorder: A Review of the Current Literature.
Worden B, Tolin D. Co-occurring Obsessive-Compulsive Disorder and Hoarding Disorder: A Review of the Current Literature. Journal Of Cognitive Psychotherapy 2022, 36: 271-286. PMID: 36635053, DOI: 10.1891/jcp-2021-0010.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderContext of OCDCognitive behavioral therapyCo-occurring obsessive-compulsive disorderResponse preventionHoarding DisorderHoarding symptomsOCD symptomsAnxiety symptomsTheoretical conceptualizationBelief patternsDifferential diagnosisTic disordersCurrent researchConceptualizationDisordersPhenomenological aspectsComorbidity profilesEtiological factorsTreatment protocolSymptoms
2021
Low Estradiol May Not Impede Cognitive Restructuring in Women With Anxiety Disorders.
Levy H, Jean A, Ching T, Nett A, Mullins J, Tolin D. Low Estradiol May Not Impede Cognitive Restructuring in Women With Anxiety Disorders. Journal Of Cognitive Psychotherapy 2021, 35: 212-220. PMID: 34362860, DOI: 10.1891/jcpsy-d-20-00038.Peer-Reviewed Original ResearchConceptsCognitive restructuringCognitive reappraisalAnxiety disordersCR taskExtinction-based therapiesSubjective distress ratingsPrimary anxiety disorderSkin conductance responsesLow estradiol groupFear extinctionNegative affectPsychophysiological arousalConductance responsesDistress ratingsCR outcomesCR abilityLow estradiolCR skillsExtinction processPrior researchTaskReappraisalEstradiol groupDisordersAcquisitionPsychophysiological assessment of stress reactivity and recovery in anxiety disorders
Tolin DF, Lee E, Levy HC, Das A, Mammo L, Katz BW, Diefenbach GJ. Psychophysiological assessment of stress reactivity and recovery in anxiety disorders. Journal Of Anxiety Disorders 2021, 82: 102426. PMID: 34022509, DOI: 10.1016/j.janxdis.2021.102426.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderCognitive behavioral therapyAnxiety disordersPanic disorderStressor phaseCBT outcomeHigh-frequency heart rate variabilityFrequency heart rate variabilityPsychophysiological reactivityEnd-tidal CODSM-5 anxiety disordersSpecialty outpatient clinicsHealthy control participantsHeart rate variabilityAdult patientsOutpatient clinicRate recoveryPatientsReactivity phaseResting phaseAnxious patientsAutonomic recoveryRate variabilityControl participantsDiminished changesVirtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders
Disorder W, Disorder A, Disorder B, Disorder M, Disorder O, Groups A, Patel Y, Parker N, Shin J, Howard D, French L, Thomopoulos S, Pozzi E, Abe Y, Abé C, Anticevic A, Alda M, Aleman A, Alloza C, Alonso-Lana S, Ameis S, Anagnostou E, McIntosh A, Arango C, Arnold P, Asherson P, Assogna F, Auzias G, Ayesa-Arriola R, Bakker G, Banaj N, Banaschewski T, Bandeira C, Baranov A, Bargalló N, Bau C, Baumeister S, Baune B, Bellgrove M, Benedetti F, Bertolino A, Boedhoe P, Boks M, Bollettini I, del Mar Bonnin C, Borgers T, Borgwardt S, Brandeis D, Brennan B, Bruggemann J, Bülow R, Busatto G, Calderoni S, Calhoun V, Calvo R, Canales-Rodríguez E, Cannon D, Carr V, Cascella N, Cercignani M, Chaim-Avancini T, Christakou A, Coghill D, Conzelmann A, Crespo-Facorro B, Cubillo A, Cullen K, Cupertino R, Daly E, Dannlowski U, Davey C, Denys D, Deruelle C, Di Giorgio A, Dickie E, Dima D, Dohm K, Ehrlich S, Ely B, Erwin-Grabner T, Ethofer T, Fair D, Fallgatter A, Faraone S, Fatjó-Vilas M, Fedor J, Fitzgerald K, Ford J, Frodl T, Fu C, Fullerton J, Gabel M, Glahn D, Roberts G, Gogberashvili T, Goikolea J, Gotlib I, Goya-Maldonado R, Grabe H, Green M, Grevet E, Groenewold N, Grotegerd D, Gruber O, Gruner P, Guerrero-Pedraza A, Gur R, Gur R, Haar S, Haarman B, Haavik J, Hahn T, Hajek T, Harrison B, Harrison N, Hartman C, Whalley H, Heslenfeld D, Hibar D, Hilland E, Hirano Y, Ho T, Hoekstra P, Hoekstra L, Hohmann S, Hong L, Höschl C, Høvik M, Howells F, Nenadic I, Jalbrzikowski M, James A, Janssen J, Jaspers-Fayer F, Xu J, Jonassen R, Karkashadze G, King J, Kircher T, Kirschner M, Koch K, Kochunov P, Kohls G, Konrad K, Krämer B, Krug A, Kuntsi J, Kwon J, Landén M, Landrø N, Lazaro L, Lebedeva I, Leehr E, Lera-Miguel S, Lesch K, Lochner C, Louza M, Luna B, Lundervold A, MacMaster F, Maglanoc L, Malpas C, Portella M, Marsh R, Martyn F, Mataix-Cols D, Mathalon D, McCarthy H, McDonald C, McPhilemy G, Meinert S, Menchón J, Minuzzi L, Mitchell P, Moreno C, Morgado P, Muratori F, Murphy C, Murphy D, Mwangi B, Nabulsi L, Nakagawa A, Nakamae T, Namazova L, Narayanaswamy J, Jahanshad N, Nguyen D, Nicolau R, Tuura R, O'Hearn K, Oosterlaan J, Opel N, Ophoff R, Oranje B, de la Foz V, Overs B, Paloyelis Y, Pantelis C, Parellada M, Pauli P, Picó-Pérez M, Picon F, Piras F, Piras F, Plessen K, Pomarol-Clotet E, Preda A, Puig O, Quidé Y, Radua J, Ramos-Quiroga J, Rasser P, Rauer L, Reddy J, Redlich R, Reif A, Reneman L, Repple J, Retico A, Richarte V, Richter A, Rosa P, Rubia K, Hashimoto R, Sacchet M, Salvador R, Santonja J, Sarink K, Sarró S, Satterthwaite T, Sawa A, Schall U, Schofield P, Schrantee A, Seitz J, Serpa M, Setién-Suero E, Shaw P, Shook D, Silk T, Sim K, Simon S, Simpson H, Singh A, Skoch A, Skokauskas N, Soares J, Soreni N, Soriano-Mas C, Spalletta G, Spaniel F, Lawrie S, Stern E, Stewart S, Takayanagi Y, Temmingh H, Tolin D, Tomecek D, Tordesillas-Gutiérrez D, Tosetti M, Uhlmann A, van Amelsvoort T, van der Wee N, van der Werff S, van Haren N, van Wingen G, Vance A, Vázquez-Bourgon J, Vecchio D, Venkatasubramanian G, Vieta E, Vilarroya O, Vives-Gilabert Y, Voineskos A, Völzke H, von Polier G, Walton E, Weickert T, Weickert C, Weideman A, Wittfeld K, Wolf D, Wu M, Yang T, Yang K, Yoncheva Y, Yun J, Cheng Y, Zanetti M, Ziegler G, Franke B, Hoogman M, Buitelaar J, van Rooij D, Andreassen O, Ching C, Veltman D, Schmaal L, Stein D, van den Heuvel O, Turner J, van Erp T, Pausova Z, Thompson P, Paus T. Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders. JAMA Psychiatry 2021, 78: 47-63. PMID: 32857118, PMCID: PMC7450410, DOI: 10.1001/jamapsychiatry.2020.2694.Peer-Reviewed Original ResearchAdolescentAdultAgedAged, 80 and overAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderBipolar DisorderCase-Control StudiesCerebral CortexChildChild, PreschoolCohort StudiesComputational BiologyDepressive Disorder, MajorFemaleFetal DevelopmentGene ExpressionHuman DevelopmentHumansMagnetic Resonance ImagingMaleMiddle AgedObsessive-Compulsive DisorderPrincipal Component AnalysisSchizophreniaYoung Adult
2017
A Multisite Benchmarking Trial of Capnometry Guided Respiratory Intervention for Panic Disorder in Naturalistic Treatment Settings
Tolin DF, McGrath PB, Hale LR, Weiner DN, Gueorguieva R. A Multisite Benchmarking Trial of Capnometry Guided Respiratory Intervention for Panic Disorder in Naturalistic Treatment Settings. Applied Psychophysiology And Biofeedback 2017, 42: 51-58. PMID: 28194546, PMCID: PMC5344940, DOI: 10.1007/s10484-017-9354-4.Peer-Reviewed Original ResearchConceptsPanic disorderRespiratory interventionsTreatment settingsTreatment of PDGlobal illness severityTreat response rateNaturalistic treatment settingEnd-tidal CO2Normocapnic rangeRemission rateIllness severityPresent studyClinical resultsFunctional impairmentRepresentative patientsResponse rateClinical settingSimilar outcomesHypocapnic rangeSimilar decreasePanic severityInterventionHome useCliniciansClient adherence
2016
RANDOMIZED TRIAL OF D‐CYCLOSERINE ENHANCEMENT OF COGNITIVE‐BEHAVIORAL THERAPY FOR PANIC DISORDER
Otto MW, Pollack MH, Dowd SM, Hofmann SG, Pearlson G, Szuhany KL, Gueorguieva R, Krystal JH, Simon NM, Tolin DF. RANDOMIZED TRIAL OF D‐CYCLOSERINE ENHANCEMENT OF COGNITIVE‐BEHAVIORAL THERAPY FOR PANIC DISORDER. Depression And Anxiety 2016, 33: 737-745. PMID: 27315514, PMCID: PMC5958622, DOI: 10.1002/da.22531.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBenzodiazepine usePanic disorderDCS augmentationMulticenter trialD-cycloserineRecent multicenter trialPanic Disorder Severity ScaleExposure-based cognitive-behavioral therapySessions of treatmentStudy pillsPrimary outcomeRandomized trialsBaseline severityPrimary diagnosisAugmentation effectTreatment responseTreatment endpointBooster sessionsSeverity ScaleRole of severityBehavioral therapyDCS efficacyBeneficial effectsPilot studyPsychometric Properties of a Structured Diagnostic Interview for DSM-5 Anxiety, Mood, and Obsessive-Compulsive and Related Disorders
Tolin DF, Gilliam C, Wootton BM, Bowe W, Bragdon LB, Davis E, Hannan SE, Steinman SA, Worden B, Hallion LS. Psychometric Properties of a Structured Diagnostic Interview for DSM-5 Anxiety, Mood, and Obsessive-Compulsive and Related Disorders. Assessment 2016, 25: 3-13. PMID: 26988404, DOI: 10.1177/1073191116638410.Peer-Reviewed Original ResearchConceptsSelf-report measuresDiagnostic InterviewSymptoms of anxietyDSM-5 AnxietyDSM-5 disordersTest-retest reliability dataTest-retest reliabilityObsessive-CompulsiveConvergent validityPsychometric propertiesAnxietyMoodRelated disordersInterrater reliability dataGroup comparisonsNeuropsychiatric disorders
2015
Hoarding and emotional reactivity: The link between negative emotional reactions and hoarding symptomatology
Shaw A, Timpano K, Steketee G, Tolin D, Frost R. Hoarding and emotional reactivity: The link between negative emotional reactions and hoarding symptomatology. Journal Of Psychiatric Research 2015, 63: 84-90. PMID: 25732668, PMCID: PMC4387091, DOI: 10.1016/j.jpsychires.2015.02.009.Peer-Reviewed Original ResearchConceptsGeneral emotional reactivityEmotional reactivityNegative emotional reactionsEmotional reactionsIntense negative emotional reactionsCognitive-behavioral modelIntense negative emotionsIntense emotional reactionsCo-occurring moodExcessive acquiringCognitive factorsProcessing emotionsNegative emotionsEmotional filmsDifficulty discardingAnxiety symptomsAnalog samplesSymptom provocationBrain regionsMemoryEmotionsCurrent studyFearParticipantsHD etiology
2010
Is cognitive–behavioral therapy more effective than other therapies? A meta-analytic review
Tolin DF. Is cognitive–behavioral therapy more effective than other therapies? A meta-analytic review. Clinical Psychology Review 2010, 30: 710-720. PMID: 20547435, DOI: 10.1016/j.cpr.2010.05.003.Peer-Reviewed Original Research
2006
Sex Differences in Trauma and Posttraumatic Stress Disorder: A Quantitative Review of 25 Years of Research
Tolin DF, Foa EB. Sex Differences in Trauma and Posttraumatic Stress Disorder: A Quantitative Review of 25 Years of Research. Psychological Bulletin 2006, 132: 959-992. PMID: 17073529, DOI: 10.1037/0033-2909.132.6.959.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderFemale participantsGreater posttraumatic stress disorderChild sexual abuseMale participantsSex differencesSpecific PTEsNonsexual assaultTraumatic eventsPTSD riskSexual abuseSexual assaultParticipantsQuantitative reviewAssaultYears of researchDisordersPTEsAbuseParticular typeVictimsCombatTraumaDifferences
2003
Thought control strategies in obsessive-compulsive disorder: a replication and extension
Abramowitz J, Whiteside S, Kalsy S, Tolin D. Thought control strategies in obsessive-compulsive disorder: a replication and extension. Behaviour Research And Therapy 2003, 41: 529-540. PMID: 12711262, DOI: 10.1016/s0005-7967(02)00026-8.Peer-Reviewed Original Research
2001
Fixity of belief, perceptual aberration, and magical ideation in obsessive–compulsive disorder
Tolin D, Abramowitz J, Kozak M, Foa E. Fixity of belief, perceptual aberration, and magical ideation in obsessive–compulsive disorder. Journal Of Anxiety Disorders 2001, 15: 501-510. PMID: 11764309, DOI: 10.1016/s0887-6185(01)00078-0.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMagical ideationPerceptual distortionStandard cognitive behavioral therapyReligious obsessionsPsychotic-like featuresCognitive behavioral therapyTypes of obsessionsPsychotic-like symptomsPerceptual AberrationDistressing obsessionsOCD severityOCD patientsPoor insightMere differencePrevious findingsObsessionPsychotic symptomsIdeationBeliefsParticipantsIndividualsMore researchTreatment outcomesDisordersMemory and memory confidence in obsessive–compulsive disorder
Tolin D, Abramowitz J, Brigidi B, Amir N, Street G, Foa E. Memory and memory confidence in obsessive–compulsive disorder. Behaviour Research And Therapy 2001, 39: 913-927. PMID: 11480832, DOI: 10.1016/s0005-7967(00)00064-4.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMemory confidenceAnxious controlsNonanxious controlsMemory accuracyPrimary checkingThreat-related stimuliLong-term memoryLow confidenceSuch deficitsPathological doubtMemory deficitsSame stimuliGroup differencesOCDMemoryUnsafe objectsStimuliPrevious researchSet of objectsDeficitsEmpirical evidenceIndividualsConfidenceObjectsParadoxical effects of thought suppression: a meta-analysis of controlled studies
Abramowitz J, Tolin D, Street G. Paradoxical effects of thought suppression: a meta-analysis of controlled studies. Clinical Psychology Review 2001, 21: 683-703. PMID: 11434226, DOI: 10.1016/s0272-7358(00)00057-x.Peer-Reviewed Original Research
2000
Science and pseudoscience in the development of eye movement desensitization and reprocessing Implications for clinical psychology
Herbert J, Lilienfeld S, Lohr J, Montgomery R, O'Donohue W, Rosen G, Tolin D. Science and pseudoscience in the development of eye movement desensitization and reprocessing Implications for clinical psychology. Clinical Psychology Review 2000, 20: 945-971. PMID: 11098395, DOI: 10.1016/s0272-7358(99)00017-3.Peer-Reviewed Original Research